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| <StructureSection load='' size='400' side='right' caption='Structure of rat transducin α (deepskyblue), β (green) and γ (gold) subunits complex with GDP (PDB code [[1gp2]]).' scene='59/590984/Cv/1' pspeed='8'> | | <StructureSection load='' size='350' side='right' caption='Structure of rat transducin α (deepskyblue), β (green) and γ (gold) subunits complex with GDP (PDB code [[1gp2]]).' scene='59/590984/Cv/1' pspeed='8'> |
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| | __TOC__ |
| == Function == | | == Function == |
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| '''Transducin''' (TDN) or '''Heterotrimeric G protein''' or '''Guanine nucleotide-binding protein G''' is a <scene name='59/590984/Cv/2'>heterotrimeric G protein containing 3 chains: α, β and γ</scene> which are organized in two subunits: α and βγ<ref>PMID:2534964</ref>. TDN is involved in phototransduction. The absorption of a photon by retinal causes a change in the conformation of rhodopsin into metarhodopsin II. The latter causes activation of TDN. Upon TDN activation the <scene name='59/590984/Cv/4'>GDP bound to its α subunit</scene> is exchanged for the GTP from the cytoplasm. Deactivation of TDN occurs when the GTP bound to the α subunit is hydrolyzed to GDP. Phosducin binds to the βγ subunit of TDN preventing its re-association with the α subunit. | | '''Transducin''' (TDN) or '''Heterotrimeric G protein''' or '''Guanine nucleotide-binding protein G''' is a <scene name='59/590984/Cv/5'>heterotrimeric G protein containing 3 chains: α, β and γ</scene> which are organized in two subunits: '''α''' and '''βγ'''<ref>PMID:2534964</ref>. TDN is involved in phototransduction. The absorption of a photon by retinal causes a change in the conformation of rhodopsin into metarhodopsin II. The latter causes activation of TDN. Upon TDN activation the <scene name='59/590984/Cv/6'>GDP bound to its α subunit</scene> is exchanged for the GTP from the cytoplasm. Deactivation of TDN occurs when the GTP bound to the α subunit is hydrolyzed to GDP. Phosducin binds to the βγ subunit of TDN preventing its re-association with the α subunit. |
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| == Disease == | | == Disease == |
| Congenital stationary night blindness (Nougaret disease) is caused by a mutation in TDN α subunit<ref>PMID:8673138</ref>. | | Congenital stationary night blindness (Nougaret disease) is caused by a mutation in TDN α subunit<ref>PMID:8673138</ref>. |
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| </StructureSection>
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| ==3D structures of transducin== | | ==3D structures of transducin== |
| | [[Transducin 3D structures]] |
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| Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
| | </StructureSection> |
| {{#tree:id=OrganizedByTopic|openlevels=0|
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| *Transducin-α
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| **[[1tnd]] – bTDN + GTPγS - bovine<br />
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| **[[1tag]] – bTDN + GDP<br />
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| **[[3v00]] – b/ratTDN + GDP<br />
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| **[[1tad]] – bTDN + GDP + AlF4<br />
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| **[[1fqk]] – bTDN + RGS9 + GDP + AlF4<br />
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| **[[1fqj]] – bTDN + RGS9 + GMP-PDE γ + GDP + AlF4<br />
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| *Transducin-βγ
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| **[[1tbg]] – bTDN <br />
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| **[[2trc]], [[1a0r]], [[1b9x]], [[1b9y]] – bTDN + phosducin<br />
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| **[[1omw]], [[3cik]] – bTDN + G-protein coupled receptor kinase 2<br />
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| **[[3v5w]] – bTDN (mutant) + G-protein coupled receptor kinase 2<br />
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| **[[3psc]], [[3pvu]], [[3pvw]], [[4mk0]] – bTDN + β-adrenergic receptor kinase 1<br />
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| **[[5he0]], [[5he1]], [[5he2]], [[5he3]], [[5ukk]], [[5ukl]], [[5ukm]] – hTDN + β-adrenergic receptor kinase 1 + inhibitor<br />
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| **[[4pnk]] – TDN hβ + bγ (mutant)+ β-adrenergic receptor kinase 1 + inhibitor<br />
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| **[[2bcj]] – bTDN (mutant) + β-adrenergic receptor kinase 1<br />
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| **[[3uzs]] – bTDN + β-adrenergic receptor kinase 1 + RNA<br />
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| **[[3krw]], [[3krx]] – bTDN + G-protein coupled receptor kinase 2 + inhibitor<br />
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| **[[1xhm]] – bTDN + peptide<br />
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| **[[4kfm]] – hTDN + G-protein activated inward rectifier K+ channel<br />
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| *Transducin-α+βγ
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| **[[1got]] – bTDN + GDP<br />
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| **[[1gg2]] – TDN rα (mutant) + bβγ + GDP - rat<br />
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| **[[1gp2]], [[5kdo]] – TDN rα + bβγ + GDP <br />
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| **[[3ah8]] – TDN rα + bβ + bγ (mutant) + GDP + inhibitor<br />
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| **[[3sn6]] – TDN bα (mutant) + rβ (mutant) +bγ + endolysine + antibody fragment<br />
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| **[[5tdh]] – TDN hα (mutant) + rβ + bγ + GDP<br />
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| **[[5uz7]] – hTDN + calcitonin receptor + antibody fragment - Cryo EM<br />
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| **[[5vai]] – TDN hα + rβ + bγ+ glucagon-like peptide + antibody fragment - Cryo EM<br />
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| }}
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| == References == | | == References == |
| <references/> | | <references/> |
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| [[Category: Topic Page]] | | [[Category: Topic Page]] |