Transducin: Difference between revisions

← Older edit

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Jaime Prilusky, Alexander Berchansky, Joel L. Sussman

@@ Line 1: / Line 1: @@
-<StructureSection load='1gp2' size='340' side='right' caption='Structure of rat transducin α (grey), β (green) and γ (gold) subunits complex with GDP (stick model) (PDB code [[1gp2]]).' scene=''>
+<StructureSection load='' size='350' side='right' caption='Structure of rat transducin α (deepskyblue), β (green) and γ (gold) subunits complex with GDP (PDB code [[1gp2]]).' scene='59/590984/Cv/1' pspeed='8'>
+__TOC__
 == Function ==
-'''Transducin''' (TDN) is a heterotrimeric G protein containing 3 chains: α, β and γ which are organized in two subunits: α and βγ<ref>PMID:2534964</ref>.  TDN is involved in phototransduction.  The absorption of a photon by retinal causes a change in the conformation of rhodopsin into metarhodopsin II.  The latter causes activation of TDN.  Upon TDN activation the GDP bound to its α subunit is exchanged for the GTP from the cytoplasm.  Deactivation of TDN occurs when the GTP bound to the α subunit is hydrolyzed to GDP.  Phosducin binds to the βγ subunit of TND preventing its re-association with the α subunit.
+'''Transducin''' (TDN) or '''Heterotrimeric G protein''' or '''Guanine nucleotide-binding protein G''' is a <scene name='59/590984/Cv/5'>heterotrimeric G protein containing 3 chains: α, β and γ</scene> which are organized in two subunits: '''α''' and '''βγ'''<ref>PMID:2534964</ref>. TDN is involved in phototransduction.  The absorption of a photon by retinal causes a change in the conformation of rhodopsin into metarhodopsin II.  The latter causes activation of TDN. Upon TDN activation the <scene name='59/590984/Cv/6'>GDP bound to its α subunit</scene> is exchanged for the GTP from the cytoplasm.  Deactivation of TDN occurs when the GTP bound to the α subunit is hydrolyzed to GDP. Phosducin binds to the βγ subunit of TDN preventing its re-association with the α subunit.
 == Disease ==
 Congenital stationary night blindness (Nougaret disease) is caused by a mutation in TDN α subunit<ref>PMID:8673138</ref>.
-</StructureSection>
 ==3D structures of transducin==
+[[Transducin 3D structures]]
-Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
+</StructureSection>
-{{#tree:id=OrganizedByTopic|openlevels=0|
-*Transducin-α
-**[[1tnd]] – bTDN + GTPγS - bovine<br />
-**[[1tag]] – bTDN + GDP<br />
-**[[3v00]] – b/ratTDN + GDP<br />
-**[[1tad]] – bTDN + GDP + AlF4<br />
-**[[1fqk]] – bTDN + RGS9 + GDP + AlF4<br />
-**[[1fqj]] – bTDN + RGS9 + GMP-PDE γ + GDP + AlF4<br />
-*Transducin-βγ
-**[[1tbg]] – bTDN <br />
-**[[2trc]], [[1a0r]], [[1b9x]], [[1b9y]] – bTDN + phosducin<br />
-**[[1omw]], [[3cik]] – bTDN + G-protein coupled receptor kinase 2<br />
-**[[3v5w]] – bTDN (mutant) + G-protein coupled receptor kinase 2<br />
-**[[3psc]], [[3pvu]], [[3pvw]], [[4mk0]] – bTDN + β-adrenergic receptor kinase 1<br />
-**[[2bcj]] – bTDN (mutant) + β-adrenergic receptor kinase 1<br />
-**[[3uzs]] – bTDN + β-adrenergic receptor kinase 1 + RNA<br />
-**[[3krw]], [[3krx]] – bTDN + G-protein coupled receptor kinase 2 + inhibitor<br />
-**[[1xhm]] – bTDN + peptide<br />
-**[[4kfm]] – hTDN + G-protein activated inward rectifier K+ channel<br />
-*Transducin-α+βγ
-**[[1got]] – bTDN + GDP<br />
-**[[1gg2]] – rTDN + GDP - rat<br />
-**[[1gp2]] – rTDN (mutant) + GDP <br />
-**[[3ah8]] – bTDN (mutant) + GDP + inhibitor<br />
-**[[3sn6]] – bTDN (mutant) + endolysine + antibody fragment<br />
-}}
 == References ==
 <references/>
 [[Category: Topic Page]]