Tumor necrosis factor receptor: Difference between revisions

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Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

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-<StructureSection load='2q1m' size='340' side='right' caption='Structure of human TNFRSF-18 extracellular domain (PDB code [[2q1m]]).' scene=''>
+<StructureSection load='1ext' size='350' side='right' caption='Structure of human TNFR extracellular domain complex with sulfate and Mg+2 ion (green) (PDB code [[1ext]]).' scene='' pspeed='8'>
+__TOC__
 == Function ==
-'''Tumor necrosis factor receptor''' (TNFR) or '''death receptor''' is  a trimeric cytokine receptor which binds TNF.  TNFR family contains several members and superfamily (TNFRSF) members.  The extracellular domain of TNFR contains 2 to 6 cysteine-rich domains.  '''TNFRSF 6''' is called '''Fas'''; '''TNFRSF 10B''' is called '''Dr5'''; '''TNFRSF 21''' is called '''Dr6'''; '''TNFRSF 11A''' is called '''RANK'''; '''TNFRSF 18''' is called '''GITRL'''.
+'''Tumor necrosis factor receptor''' (TNFR) or '''death receptor''' is  a trimeric cytokine receptor which binds TNF<ref>PMID:10358762</ref>.  TNFR family contains several members and superfamily ('''TNFRSF''') members.  <br />
+*  '''TNFRSF 1''' is called '''Lymphotoxin-α or TNF-β'''<ref>PMID:20566898</ref>;<br />
+*  '''TNFRSF 3''' is called '''TNFR-III''';<br />
+*  '''TNFRSF 4''' is called '''OX40L receptor''';<br />
+*  '''TNFRSF 5''' is called '''CD40L receptor''';<br />
+*  '''TNFRSF 6''' is called '''Fas''';<br />
+*  '''TNFRSF 9''' is called '''4-1BBL''';<br />
+* '''TNFRSF 10''' see [[TRAIL]];<br />
+* '''TNFRSF 10B''' is called '''Dr5''';<br />
+*  '''TNFRSF 11A''' is called '''RANK''';<br />
+*  '''TNFRSF 11B''' is called '''Osteoprotegerin''';<br />
+*  '''TNFRSF 12''' is called '''TWEAK''';<br />
+*  '''TNFRSF 12A''' is called '''TWEAKR''';<br />
+*  '''TNFRSF 13B''' is called '''BAFF or sTALL-1''';<br />
+*  '''TNFRSF 13C''' is called '''BAFF receptor''';<br />
+*  '''TNFRSF 14''' is called '''LIGHT''';<br />
+* '''TNFRSF 16''' is called '''Low-affinity nerve growth factor receptor; p75NTR; p75 neurotrophin receptor''';<br />
+* '''TNFRSF 18''' is called '''GITRL''';<br />
+* '''TNFRSF 21''' is called '''Dr6''';<br />
+* '''TNFRSF 25''' is called '''Dr3''';<br />
-== Disease ==
+See also
+*[[Tumor necrosis factor ligand superfamily]]
+*[[Cytokine receptors]]
+*[[Receptor]]
+*[[Immune receptors]]
 == Relevance ==
+TRAPS - a condition characterized by recurrent episodes of fever is associated with TNFR<ref>PMID:24609716</ref>.
 == Structural highlights ==
+The extracellular domain of TNFR contains 2 to 6 cysteine-rich domains (CRD). The <scene name='59/590824/Cv/8'>CRD domains are ca. 40 amino-acid long and contain 4-6 cysteine residues</scene>. The CRDs are involved in binding of TNF<ref>PMID:8939750</ref>. <scene name='59/590824/Cv/9'>Mg coordination site</scene>. Water molecules are shown as red spheres.
 ==3D structures of tumor necrosis factor receptor==
+[[Tumor necrosis factor receptor 3D structures]]
-Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
+</StructureSection>
-===TNFR-1===
-[[1ncf]] – hTNFR-1 residues 12-172 (mutant) – human<br />
-[[1ich]] – hTNFR-1 death domain (mutant) - NMR<br />
-[[2eqp]] – hTNFR-1 residues 28-70 – NMR <br />
-[[1ext]] – hTNFR-1 extracellular domain <br />
-[[1ft4]] – hTNFR-1 extracellular domain + inhibitor<br />
-[[3on9]] – evTNFR SECRET domain – ectromelia virus<br />
-[[3ona]] – evTNFR SECRET domain + CX3CL1 <br />
-===TNFRSF-1B===
-[[3alq]] – hTNFRSF-1B extracellular domain + TNF<br />
-===TNFRSF-6 (Fas)===
-[[3thm]], [[3tje]] – hTNFRSF-6 extracellular domain + antibody<br />
-[[3ezq]] – hTNFRSF-6 Fas DD domain + FADD<br />
-[[3oq9]] – mTNFRSF-6 Fas DD domain + FADD - mouse<br />
-===TNFRSF-6B===
-[[3mhd]] – hTNFRSF-6B extracellular domain <br />
-[[4msv]] – hTNFRSF-6B extracellular domain + hTNFRSF-6 extracellular domain<br />
-[[4kgg]], [[4kgq]], [[4j6g]] – hTNFRSF-6B extracellular domain + hTNFRSF-14 extracellular domain<br />
-[[3mi8]] – hTNFRSF-6B extracellular domain + hTNFRSF-15 extracellular domain<br />
-[[3k51]] – hTNFRSF-6B cysteine-rich domain + hTNFRSF-15 extracellular domain<br />
-===TNFRSF-10B (Dr5)===
-[[2h9g]], [[4od2]], [[1za3]] – hTNFRSF-10B extracellular domain + antibody<br />
-[[1d0g]] – hTNFRSF-10B extracellular domain + apoptosis-2 ligand<br />
-[[1d4v]] – hTNFRSF-10B extracellular domain + TNF-related apoptosis inducing ligand<br />
-===TNFRSF-11A (RANK)===
-[[3me4]] – mTNFRSF-11A extracellular domain <br />
-[[4giq]], [[3qbq]], [[3me2]] – mTNFRSF-11A extracellular domain + RANKL <br />
-===TNFRSF-12A===
-[[2rpj]] – hTNFRSF-12A cysteine-rich domain – NMR <br />
-===TNFRSF-18 (GITRL)===
-[[4db5]] – TNFRSF-18 – rabbit <br />
-[[4e4s]] – TNFRSF-18 – pika <br />
-[[4g4f]] – TNFRSF-18 – bushbaby <br />
-[[3fc0]], [[2qdn]], [[3b9i]] – mTNFRSF-18  <br />
-[[2q1m]] – hTNFRSF-18 extracellular domain  <br />
-[[2r30]], [[2r32]] – hTNFRSF-18 extracellular domain (mutant) <br />
-===TNFRSF-21 (Dr6)===
-[[3u3p]], [[3u3q]], [[3u3s]], [[3u3t]], [[3u3v]] – hTNFRSF-21 cysteine-rich domain<br />
-[[2dbh]] – hTNFRSF-21 CARD-like domain - NMR<br />
-[[3qo4]] – hTNFRSF-21 residues 42-218<br />
 == References ==