4d00: Difference between revisions

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 <StructureSection load='4d00' size='340' side='right'caption='[[4d00]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[4d00]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Influenza_virus Influenza virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4D00 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4D00 FirstGlance]. <br>
+<table><tr><td colspan='2'>[[4d00]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Unidentified_influenza_virus Unidentified influenza virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4D00 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4D00 FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene>, <scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
-<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4cyv|4cyv]], [[4cyw|4cyw]], [[4cyz|4cyz]], [[4cz0|4cz0]]</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene>, <scene name='pdbligand=PRD_900046:6-sialyl-N-acetyllactosamine'>PRD_900046</scene>, <scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4d00 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4d00 OCA], [http://pdbe.org/4d00 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4d00 RCSB], [http://www.ebi.ac.uk/pdbsum/4d00 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4d00 ProSAT]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4d00 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4d00 OCA], [https://pdbe.org/4d00 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4d00 RCSB], [https://www.ebi.ac.uk/pdbsum/4d00 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4d00 ProSAT]</span></td></tr>
 </table>
+== Function ==
+[https://www.uniprot.org/uniprot/HEMA_I84A3 HEMA_I84A3] Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore.  Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization either through clathrin-dependent endocytosis or through clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore.[HAMAP-Rule:MF_04072]
 <div style="background-color:#fffaf0;">
 == Publication Abstract from PubMed ==
@@ Line 19: / Line 21: @@
 ==See Also==
-*[[Hemagglutinin|Hemagglutinin]]
+*[[Hemagglutinin 3D structures|Hemagglutinin 3D structures]]
 == References ==
 <references/>
 __TOC__
 </StructureSection>
-[[Category: Influenza virus]]
 [[Category: Large Structures]]
-[[Category: Collins, P J]]
+[[Category: Unidentified influenza virus]]
-[[Category: Gamblin, S J]]
+[[Category: Collins PJ]]
-[[Category: Haire, L F]]
+[[Category: Gamblin SJ]]
-[[Category: Martin, S R]]
+[[Category: Haire LF]]
-[[Category: McCauley, J W]]
+[[Category: Martin SR]]
-[[Category: Skehel, J J]]
+[[Category: McCauley JW]]
-[[Category: Vachieri, S G]]
+[[Category: Skehel JJ]]
-[[Category: Walker, P A]]
+[[Category: Vachieri SG]]
-[[Category: Xiong, X]]
+[[Category: Walker PA]]
-[[Category: Zhang, Y]]
+[[Category: Xiong X]]
-[[Category: Avian flu]]
+[[Category: Zhang Y]]
-[[Category: Glycoprotein]]
-[[Category: H10n8]]
-[[Category: Influenza]]
-[[Category: Lsta]]
-[[Category: Sialic acid]]
-[[Category: Sialyllactosamine]]
-[[Category: Viral protein]]
-[[Category: Virus receptor]]