4pz4: Difference between revisions

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OCA

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 ==High-resolution crystal structure of the human CD44 hyaluronan binding domain in new space group==
-<StructureSection load='4pz4' size='340' side='right' caption='[[4pz4]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
+<StructureSection load='4pz4' size='340' side='right'caption='[[4pz4]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[4pz4]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PZ4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4PZ4 FirstGlance]. <br>
+<table><tr><td colspan='2'>[[4pz4]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PZ4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4PZ4 FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6&#8491;</td></tr>
-<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1uuh|1uuh]], [[4pz3|4pz3]]</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4pz4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pz4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4pz4 RCSB], [http://www.ebi.ac.uk/pdbsum/4pz4 PDBsum]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4pz4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pz4 OCA], [https://pdbe.org/4pz4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4pz4 RCSB], [https://www.ebi.ac.uk/pdbsum/4pz4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4pz4 ProSAT]</span></td></tr>
 </table>
+== Function ==
+[https://www.uniprot.org/uniprot/CD44_HUMAN CD44_HUMAN] Receptor for hyaluronic acid (HA). Mediates cell-cell and cell-matrix interactions through its affinity for HA, and possibly also through its affinity for other ligands such as osteopontin, collagens, and matrix metalloproteinases (MMPs). Adhesion with HA plays an important role in cell migration, tumor growth and progression. Also involved in lymphocyte activation, recirculation and homing, and in hematopoiesis. Altered expression or dysfunction causes numerous pathogenic phenotypes. Great protein heterogeneity due to numerous alternative splicing and post-translational modification events.
 <div style="background-color:#fffaf0;">
 == Publication Abstract from PubMed ==
@@ Line 15: / Line 18: @@
 From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 </div>
+<div class="pdbe-citations 4pz4" style="background-color:#fffaf0;"></div>
+==See Also==
+*[[CD44|CD44]]
 == References ==
 <references/>
 __TOC__
 </StructureSection>
-[[Category: Finzel, B.]]
+[[Category: Homo sapiens]]
-[[Category: Liu, L K.]]
+[[Category: Large Structures]]
-[[Category: Binding protein]]
+[[Category: Finzel B]]
-[[Category: Cell adhesion]]
+[[Category: Liu LK]]
-[[Category: Ectodomain]]
-[[Category: Hyaluronan]]
-[[Category: Link module]]