4os3: Difference between revisions

<table><tr><td colspan='2'>[[4os3]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OS3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4OS3 FirstGlance]. <br>

</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.4&#8491;</td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4os3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4os3 OCA], [https://pdbe.org/4os3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4os3 RCSB], [https://www.ebi.ac.uk/pdbsum/4os3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4os3 ProSAT]</span></td></tr>

[https://www.uniprot.org/uniprot/PTGDS_HUMAN PTGDS_HUMAN] Catalyzes the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation. Involved in a variety of CNS functions, such as sedation, NREM sleep and PGE2-induced allodynia, and may have an anti-apoptotic role in oligodendrocytes. Binds small non-substrate lipophilic molecules, including biliverdin, bilirubin, retinal, retinoic acid and thyroid hormone, and may act as a scavenger for harmful hydrophopic molecules and as a secretory retinoid and thyroid hormone transporter. Possibly involved in development and maintenance of the blood-brain, blood-retina, blood-aqueous humor and blood-testis barrier. It is likely to play important roles in both maturation and maintenance of the central nervous system and male reproductive system.<ref>PMID:9475419</ref> <ref>PMID:20667974</ref>  

[[Category: Homo sapiens]]

[[Category: Bertinelli M]]

[[Category: Bertini E]]

[[Category: Bovi M]]

[[Category: Capaldi S]]

[[Category: Carrizo ME]]

[[Category: Destefanis L]]

[[Category: Monaco HL]]

[[Category: Perduca M]]