4ogq: Difference between revisions

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-'''Unreleased structure'''
-The entry 4ogq is ON HOLD
+==Internal Lipid Architecture of the Hetero-Oligomeric Cytochrome b6f Complex==
+<StructureSection load='4ogq' size='340' side='right'caption='[[4ogq]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[4ogq]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Nostoc_sp._PCC_7120_=_FACHB-418 Nostoc sp. PCC 7120 = FACHB-418]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OGQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4OGQ FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.501&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1O2:(2S)-3-(ALPHA-D-GALACTOPYRANOSYLOXY)-2-(HEXADECANOYLOXY)PROPYL+(9Z)-OCTADEC-9-ENOATE'>1O2</scene>, <scene name='pdbligand=2WA:(1S,8E)-1-{[(2S)-1-HYDROXY-3-{[(1S)-1-HYDROXYPENTADECYL]OXY}PROPAN-2-YL]OXY}HEPTADEC-8-EN-1-OL'>2WA</scene>, <scene name='pdbligand=2WD:(1R)-1-{[(2S)-3-HYDROXY-2-{[(1R)-1-HYDROXYPENTYL]OXY}PROPYL]OXY}HEXAN-1-OL'>2WD</scene>, <scene name='pdbligand=2WM:(1S,8E)-1-{[(2S)-3-HYDROXY-2-{[(1S)-1-HYDROXYOCTADECYL]OXY}PROPYL]OXY}OCTADEC-8-EN-1-OL'>2WM</scene>, <scene name='pdbligand=3WM:(1S,8E,1R,8Z)-1,1-{[(2S)-3-HYDROXYPROPANE-1,2-DIYL]BIS(OXY)}BISOCTADEC-8-EN-1-OL'>3WM</scene>, <scene name='pdbligand=7PH:(1R)-2-(DODECANOYLOXY)-1-[(PHOSPHONOOXY)METHYL]ETHYL+TETRADECANOATE'>7PH</scene>, <scene name='pdbligand=8K6:OCTADECANE'>8K6</scene>, <scene name='pdbligand=BCR:BETA-CAROTENE'>BCR</scene>, <scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=CLA:CHLOROPHYLL+A'>CLA</scene>, <scene name='pdbligand=FES:FE2/S2+(INORGANIC)+CLUSTER'>FES</scene>, <scene name='pdbligand=HEC:HEME+C'>HEC</scene>, <scene name='pdbligand=MYS:PENTADECANE'>MYS</scene>, <scene name='pdbligand=OCT:N-OCTANE'>OCT</scene>, <scene name='pdbligand=OPC:(7R,17E)-4-HYDROXY-N,N,N,7-TETRAMETHYL-7-[(8E)-OCTADEC-8-ENOYLOXY]-10-OXO-3,5,9-TRIOXA-4-PHOSPHAHEPTACOS-17-EN-1-AMINIUM+4-OXIDE'>OPC</scene>, <scene name='pdbligand=SQD:1,2-DI-O-ACYL-3-O-[6-DEOXY-6-SULFO-ALPHA-D-GLUCOPYRANOSYL]-SN-GLYCEROL'>SQD</scene>, <scene name='pdbligand=UMQ:UNDECYL-MALTOSIDE'>UMQ</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ogq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ogq OCA], [https://pdbe.org/4ogq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ogq RCSB], [https://www.ebi.ac.uk/pdbsum/4ogq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ogq ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/CYB6_NOSS1 CYB6_NOSS1] Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions (By similarity).
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+The role of lipids in the assembly, structure, and function of hetero-oligomeric membrane protein complexes is poorly understood. The dimeric photosynthetic cytochrome b6f complex, a 16-mer of eight distinct subunits and 26 transmembrane helices, catalyzes transmembrane proton-coupled electron transfer for energy storage. Using a 2.5 A crystal structure of the dimeric complex, we identified 23 distinct lipid-binding sites per monomer. Annular lipids are proposed to provide a connection for super-complex formation with the photosystem-I reaction center and the LHCII kinase enzyme for transmembrane signaling. Internal lipids mediate crosslinking to stabilize the domain-swapped iron-sulfur protein subunit, dielectric heterogeneity within intermonomer and intramonomer electron transfer pathways, and dimer stabilization through lipid-mediated intermonomer interactions. This study provides a complete structure analysis of lipid-mediated functions in a multi-subunit membrane protein complex and reveals lipid sites at positions essential for assembly and function.
-Authors: Hasan, S.S., Cramer, W.A.
+Internal Lipid Architecture of the Hetero-Oligomeric Cytochrome b6f Complex.,Hasan SS, Cramer WA Structure. 2014 Jul 8;22(7):1008-15. doi: 10.1016/j.str.2014.05.004. Epub 2014, Jun 12. PMID:24931468<ref>PMID:24931468</ref>
-Description: Lipidic Architecture of Cytochrome b6f Complex
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+</div>
+<div class="pdbe-citations 4ogq" style="background-color:#fffaf0;"></div>
+==See Also==
+*[[Cytochrome b6|Cytochrome b6]]
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Large Structures]]
+[[Category: Nostoc sp. PCC 7120 = FACHB-418]]
+[[Category: Cramer WA]]
+[[Category: Hasan SS]]