Catabolite control protein: Difference between revisions

← Older edit

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

@@ Line 1: / Line 1: @@
-<StructureSection load='2fep' size='450' side='right' caption='Structure of catabolite control protein (deepskyblue) complex with Hpr (green) and sulfate (PDB entry [[2fep]])' scene='57/570565/Cv/1'>
+<StructureSection load='2fep' size='350' side='right' caption='Structure of catabolite control protein (blue) complex with Hpr (green) and sulfate (PDB entry [[2fep]])' scene='57/570565/Cv/1'>
+== Function ==
-'''Catabolite control protein''' (CcpA) is a regulator of carbon metabolism in gram-positive bacteria.  When high concentrations of glucose-6 phosphate or fructose-1,6-diphosphate are present in the cell, they phosphorylate proteins HPr or Crh which interact with CcpA.  The latter binds to DNA operator to modulate transcription.
+'''Catabolite control protein''' (CcpA) or '''glucose-resistant amylase regulator''' is a regulator of carbon metabolism in gram-positive bacteria.  When high concentrations of glucose-6 phosphate or fructose-1,6-diphosphate are present in the cell, they phosphorylate proteins HPr or Crh which interact with CcpA.  The latter binds to DNA operator to modulate transcription.<ref>PMID:16321938</ref>
-</StructureSection>
+*'''CcpC''' Regulates the transcription of genes belonging to the TCA cycle<ref>PMID:34645869</ref> .
+*'''CcpE''' Regulates the transcription of genes belonging to the TCA cycle in ''Staphylococcus aureus''<ref>PMID:25193664</ref> .
-==3D structures of catabolite control protein==
+== Structural highlights ==
-Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
+CcpA phosphorylation activity is carried out by a <scene name='57/570565/Cv/2'>phosphorylated Ser residue</scene> (PDB entry [[2fep]]).<ref>PMID:8195089</ref> <ref>PMID:8596444</ref>
-{{#tree:id=OrganizedByTopic|openlevels=0|
-*CcpA
+==3D structures of catabolite control protein==
+[[Catabolite control protein 3D structures]]
-**[[2jcg]], [[2hsg]] - BmCcpA – ''Bacillus megaterium'' <br />
+</StructureSection>
-**[[2o20]] - CcpA (mutant) – ''Streptococcus lactis'' <br />
-*CcpA binary complex
-**[[2oen]] - BmCcpA + phosphocarrier protein HPr  <br />
-**[[2fep]] - BsCcpA + phosphocarrier protein HPr – ''Bacillus subtilis''<br />
-*CcpA ternary complex
-**[[1rzr]] – BmCcpA + phosphocarrier protein HPr + DNA  <br />
+== References ==
-**[[2nzu]] - BmCcpA + phosphocarrier protein HPr + glucose-6-phosphate  <br />
+<references/>
-**[[2nzv]] - BmCcpA + phosphocarrier protein HPr + fructose-1,6-diphosphate  <br />
-**[[1zvv]] – BsCcpA + catabolite repression Crh + DNA  <br />
-**[[3oqm]], [[3oqn]], [[3oqo]] - BsCcpA + phosphocarrier protein HPr + DNA<br />
-}}
 [[Category:Topic Page]]