Catabolite control protein: Difference between revisions

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

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+<StructureSection load='2fep' size='350' side='right' caption='Structure of catabolite control protein (blue) complex with Hpr (green) and sulfate (PDB entry [[2fep]])' scene='57/570565/Cv/1'>
-<StructureSection load='1rzr' size='350' side='right' caption='Structure of catabolite control protein complex with Hpr and DNA (PDB entry [[1rzr]])' scene=''>
+== Function ==
-'''Catabolite control protein''' (CcpA) is a regulator of carbon metabolism in gram-positive bacteria.  When high concentrations of glucose-6 phosphate or fructose-1,6-diphosphate are present in the cell, they phosphorylate proteins Hpr or Crh which interact with CcpA.  The latter binds to DNA operator to modulate transcription.
+'''Catabolite control protein''' (CcpA) or '''glucose-resistant amylase regulator''' is a regulator of carbon metabolism in gram-positive bacteria.  When high concentrations of glucose-6 phosphate or fructose-1,6-diphosphate are present in the cell, they phosphorylate proteins HPr or Crh which interact with CcpA.  The latter binds to DNA operator to modulate transcription.<ref>PMID:16321938</ref>
+*'''CcpC''' Regulates the transcription of genes belonging to the TCA cycle<ref>PMID:34645869</ref> .
+*'''CcpE''' Regulates the transcription of genes belonging to the TCA cycle in ''Staphylococcus aureus''<ref>PMID:25193664</ref> .
-==3D structures of catabolite control protein==
+== Structural highlights ==
-Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
+CcpA phosphorylation activity is carried out by a <scene name='57/570565/Cv/2'>phosphorylated Ser residue</scene> (PDB entry [[2fep]]).<ref>PMID:8195089</ref> <ref>PMID:8596444</ref>
-[[2jcg]], [[2hsg]] - BmCcpA – ''Bacillus megaterium'' <br />
+==3D structures of catabolite control protein==
-[[1sxg]], [[1sxh]], [[1sxi]] – BmCcpA (mutant)  <br />
+[[Catabolite control protein 3D structures]]
-[[2o20]] - CcpA (mutant) – ''Streptococcus lactis'' <br />
-===CcpA binary complex===
-[[2oen]] - BmCcpA + phosphocarrier protein Hpr  <br />
-[[2fep]] - BsCcpA + phosphocarrier protein Hpr – ''Bacillus subtilis''<br />
-===CcpA ternary complex===
+</StructureSection>
-[[1rzr]] – BmCcpA + phosphocarrier protein Hpr + DNA  <br />
+== References ==
-[[2nzu]] - BmCcpA + phosphocarrier protein Hpr + glucose-6-phosphate  <br />
+<references/>
-[[2nzv]] - BmCcpA + phosphocarrier protein Hpr + fructose-1,6-diphosphate  <br />
+[[Category:Topic Page]]
-[[1zvv]] – BsCcpA + catabolite repression Crh + DNA  <br />
-[[3oqm]], [[3oqn]], [[3oqo]] - BsCcpA + phosphocarrier protein Hpr + DNA<br />