4nn5: Difference between revisions

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-{{STRUCTURE_4nn5|  PDB=4nn5  |  SCENE=  }}
-===Cytokine receptor complex - Crystal form 1A===
-==Function==
+==Cytokine receptor complex - Crystal form 1A==
-[[http://www.uniprot.org/uniprot/TSLP_MOUSE TSLP_MOUSE]] Cytokine that induces the release of T-cell-attracting chemokines from monocytes and, in particular, enhances the maturation of CD11c(+) dendritic cells. Can induce allergic inflammation by directly activating mast cells (By similarity). [[http://www.uniprot.org/uniprot/CRLF2_MOUSE CRLF2_MOUSE]] Receptor for thymic stromal lymphopoietin (TSLP). Forms a functional complex with TSLP and IL7R which is capable of stimulating cell proliferation through activation of STAT3 and STAT5. Also activates JAK2. Implicated in the development of the hematopoietic system. [[http://www.uniprot.org/uniprot/IL7RA_MOUSE IL7RA_MOUSE]] Receptor for interleukin-7. Also acts as a receptor for thymic stromal lymphopoietin (TSLP).
+<StructureSection load='4nn5' size='340' side='right'caption='[[4nn5]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[4nn5]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NN5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4NN5 FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.898&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4nn5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nn5 OCA], [https://pdbe.org/4nn5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4nn5 RCSB], [https://www.ebi.ac.uk/pdbsum/4nn5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4nn5 ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/IL7RA_MOUSE IL7RA_MOUSE] Receptor for interleukin-7. Also acts as a receptor for thymic stromal lymphopoietin (TSLP).
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+Thymic stromal lymphopoietin (TSLP), a cytokine produced by epithelial cells at barrier surfaces, is pivotal for the development of widespread chronic inflammatory disorders such as asthma and atopic dermatitis. The structure of the mouse TSLP-mediated signaling complex reveals how TSLP establishes extensive interfaces with its cognate receptor (TSLPR) and the shared interleukin 7 receptor alpha-chain (IL-7Ralpha) to evoke membrane-proximal receptor-receptor contacts poised for intracellular signaling. Binding of TSLP to TSLPR is a mechanistic prerequisite for recruitment of IL-7Ralpha to the high-affinity ternary complex, which we propose is coupled to a structural switch in TSLP at the crossroads of the cytokine-receptor interfaces. Functional interrogation of TSLP-receptor interfaces points to putative interaction hotspots that could be exploited for antagonist design. Finally, we derive the structural rationale for the functional duality of IL-7Ralpha and establish a consensus for the geometry of ternary complexes mediated by interleukin 2 (IL-2)-family cytokines.
-==About this Structure==
+Structural basis of the proinflammatory signaling complex mediated by TSLP.,Verstraete K, van Schie L, Vyncke L, Bloch Y, Tavernier J, Pauwels E, Peelman F, Savvides SN Nat Struct Mol Biol. 2014 Mar 16. doi: 10.1038/nsmb.2794. PMID:24632570<ref>PMID:24632570</ref>
-[[4nn5]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NN5 OCA].
-[[Category: Savvides, S N.]]
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-[[Category: Schie, L van.]]
+</div>
-[[Category: Verstraete, K.]]
+<div class="pdbe-citations 4nn5" style="background-color:#fffaf0;"></div>
-[[Category: Cell surface]]
-[[Category: Chr domain]]
+==See Also==
-[[Category: Cytokine-cytokine receptor complex]]
+*[[Interleukin receptor 3D structures|Interleukin receptor 3D structures]]
-[[Category: Four helical bundle fold]]
+== References ==
-[[Category: Tslp cytokine signaling]]
+<references/>
-[[Category: Tslpr and il-7ralpha receptor]]
+__TOC__
+</StructureSection>
+[[Category: Large Structures]]
+[[Category: Mus musculus]]
+[[Category: Savvides SN]]
+[[Category: Verstraete K]]
+[[Category: Van Schie L]]