Sentrin-specific protease: Difference between revisions

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

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+<StructureSection load='2iy0' size='350' side='right' caption='Structure of human Senp1 catalytic domain (grey) complex with SUMO1 (green) and RanGAP C terminal (pink) (PDB entry [[2iy0]])' scene='' pspeed='8'>
-<StructureSection load='2iy0' size='350' side='right' caption='Structure of human Senp1 catalytic domain complex with SUMO1 and RanGAP C terminal (PDB entry [[2iy0]])' scene=''>
+'''Sentrin-specific protease''' 1 (Senp1), Senp2, Senp7, Senp8 catalyze the processing of SUM1, SUMO2 and SUMO3 to their mature forms and deconjugate these proteins from their target proteins.  Senp’s hydrolyze a peptide bond in the C-terminal of SUMO propeptide<ref>PMID:24586832</ref>.<br />
+*'''SENP2''' localised in cytoplasmic vesicles and nuclear body.
+*'''SENP7''' localised in breast epithelium.
-'''Sentrin-specific protease''' 1 (Senp1), Senp2, Senp7, Senp8 catalyze the processing of SUM1, SUMO2 and SUMO3 to their mature forms and deconjugate these proteins from their target proteins.  Senp’s hydrolyze a peptide bond in the C-terminal of SUMO propeptide.
+<scene name='56/568937/Cv/1'>human Senp1 catalytic domain complex with SUMO1 and RanGAP C terminal</scene> (PDB entry [[2iy0]]).
+</StructureSection>
 ==3D structures of sentrin-specific protease==
-'''Senp1'''
+Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
+{{#tree:id=OrganizedByTopic|openlevels=0|
-[[2ckg]], [[2iyc]] – hSenp1 C terminal – human<br />
+*Sentrin-specific protease 1
-[[2xph]], [[2xre]] – hSenp1 C terminal + Co<br />
-[[2ckh]], [[2iyd]] – hSenp1 C terminal + SUMO2<br />
-[[2iy1]], [[2g4d]] – hSenp1 C terminal (mutant) + SUMO1<br />
-[[2iy0]] – hSenp1 C terminal + SUMO1 + RanGAP C terminal<br />
-'''Senp2'''
+**[[2ckg]], [[2iyc]] – hSenp1 catalytic domain – human<br />
+**[[2xph]], [[2xre]] – hSenp1 catalytic domain + Co<br />
+**[[2iy1]], [[2g4d]] – hSenp1 catalytic domain (mutant) + SUMO1<br />
+**[[2ckh]], [[2iyd]] – hSenp1 catalytic domain + SUMO2<br />
+**[[6nnq]] – hSenp1 catalytic domain + SUMO3<br />
+**[[2iy0]] – hSenp1 catalytic domain + SUMO1 + RanGAP C terminal<br />
-[[1tgz]] – hSenp2 catalytic domain + SUMO1<br />
+*Sentrin-specific protease 2
-[[1th0]] – hSenp2 catalytic domain <br />
-[[2io0]] – hSenp2 catalytic domain (mutant) + SUMO1 precursor<br />
-[[2io1]] – hSenp2 catalytic domain (mutant) + SUMO3 precursor<br />
-[[2io3]] – hSenp2 catalytic domain (mutant) + SUMO2 + RanGAP C terminal<br />
-[[2io2]] – hSenp2 catalytic domain (mutant) + SUMO1 + RanGAP C terminal<br />
-'''Senp7'''
+**[[1th0]] – hSenp2 catalytic domain <br />
+**[[1tgz]] – hSenp2 catalytic domain + SUMO1<br />
+**[[2io0]], [[5aek]] – hSenp2 catalytic domain (mutant) + SUMO1 precursor<br />
+**[[3zo5]] - hSenp2 catalytic domain (mutant) + SUMO2 precursor<br />
+**[[2io1]] – hSenp2 catalytic domain (mutant) + SUMO3 precursor<br />
+**[[2io3]] – hSenp2 catalytic domain (mutant) + SUMO2 + RanGAP C terminal<br />
+**[[2io2]] – hSenp2 catalytic domain (mutant) + SUMO1 + RanGAP C terminal<br />
-[[3eay]] – hSenp7 catalytic domain + SUMO1<br />
+*Sentrin-specific protease 7
-'''Senp8'''
+**[[3eay]] – hSenp7 catalytic domain + SUMO1<br />
+**[[7r2e]] – hSenp7 catalytic domain + SUMO2<br />
-[[1xt9]], [[2bkr]] – hSenp8 + Nedd8<br />
+*Sentrin-specific protease 8
-[[2bkq]] – hSenp8 <br />
+**[[1xt9]], [[2bkr]] – hSenp8 + Nedd8<br />
+**[[2bkq]] – hSenp8 <br />
+}}
+== References ==
+<references/>
+[[Category:Topic Page]]