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==Crystal structure of the thioredoxin reductase from Entamoeba histolytica with auranofin Au(I) bound to Cys286==
==Crystal structure of the thioredoxin reductase from Entamoeba histolytica with auranofin Au(I) bound to Cys286==
<StructureSection load='4cbq' size='340' side='right' caption='[[4cbq]], [[Resolution|resolution]] 1.94&Aring;' scene=''>
<StructureSection load='4cbq' size='340' side='right'caption='[[4cbq]], [[Resolution|resolution]] 1.94&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4cbq]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CBQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4CBQ FirstGlance]. <br>
<table><tr><td colspan='2'>[[4cbq]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Entamoeba_histolytica Entamoeba histolytica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CBQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4CBQ FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AU:GOLD+ION'>AU</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.94&#8491;</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Thioredoxin-disulfide_reductase Thioredoxin-disulfide reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.8.1.9 1.8.1.9] </span></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AU:GOLD+ION'>AU</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4cbq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cbq OCA], [http://pdbe.org/4cbq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4cbq RCSB], [http://www.ebi.ac.uk/pdbsum/4cbq PDBsum]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4cbq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cbq OCA], [https://pdbe.org/4cbq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4cbq RCSB], [https://www.ebi.ac.uk/pdbsum/4cbq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4cbq ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/C4LW95_ENTH1 C4LW95_ENTH1]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 4cbq" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 4cbq" style="background-color:#fffaf0;"></div>
==See Also==
*[[Thioredoxin reductase 3D structures|Thioredoxin reductase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Thioredoxin-disulfide reductase]]
[[Category: Entamoeba histolytica]]
[[Category: Debnath, A]]
[[Category: Large Structures]]
[[Category: Hirata, K]]
[[Category: Debnath A]]
[[Category: Kells, P M]]
[[Category: Hirata K]]
[[Category: McKerrow, J H]]
[[Category: Kells PM]]
[[Category: Parsonage, D]]
[[Category: McKerrow JH]]
[[Category: Podust, L M]]
[[Category: Parsonage D]]
[[Category: Poole, L B]]
[[Category: Podust LM]]
[[Category: Reed, S L]]
[[Category: Poole LB]]
[[Category: Amoebiasis]]
[[Category: Reed SL]]
[[Category: Oxidative stress]]
[[Category: Oxidoreductase]]
[[Category: Redox metabolism]]

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