4lvq: Difference between revisions
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4lvq]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LVQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4LVQ FirstGlance]. <br> | <table><tr><td colspan='2'>[[4lvq]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LVQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4LVQ FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr> | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3Å</td></tr> | ||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4lvq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4lvq OCA], [https://pdbe.org/4lvq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4lvq RCSB], [https://www.ebi.ac.uk/pdbsum/4lvq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4lvq ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4lvq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4lvq OCA], [https://pdbe.org/4lvq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4lvq RCSB], [https://www.ebi.ac.uk/pdbsum/4lvq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4lvq ProSAT]</span></td></tr> | ||
</table> | </table> | ||
Latest revision as of 10:10, 27 November 2024
Crystal structure of the M. tuberculosis phosphate binding protein PstS3Crystal structure of the M. tuberculosis phosphate binding protein PstS3
Structural highlights
FunctionPSTS3_MYCTU Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity). Publication Abstract from PubMedMycobacterium tuberculosis evades host immune responses by colonizing macrophages. Intraphagosomal M. tuberculosis is exposed to environmental stresses such as reactive oxygen and nitrogen intermediates as well as acid shock and inorganic phosphate (Pi) depletion. Experimental evidence suggests that expression levels of mycobacterial protein PstS3 (Rv0928) are significantly increased when M. tuberculosis bacilli are exposed to Pi starvation. Hence, PstS3 may be important for survival of Mtb in conditions where there is limited supply of Pi. We report here the structure of PstS3 from M. tuberculosis at 2.3-A resolution. The protein presents a structure typical for ABC phosphate transfer receptors. Comparison with its cognate receptor PstS1 showed a different pattern distribution of surface charges in proximity to the Pi recognition site, suggesting complementary roles of the two proteins in Pi uptake. Proteins 2014. (c) 2014 Wiley Periodicals, Inc. Crystal structure of the Mycobacterium tuberculosis phosphate binding protein PstS3.,Ferraris DM, Spallek R, Oehlmann W, Singh M, Rizzi M Proteins. 2014 Mar 11. doi: 10.1002/prot.24548. PMID:24615888[1] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See AlsoReferences
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