4lhj: Difference between revisions

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OCA

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 ==Ricin A chain bound to camelid nanobody (VHH5)==
-<StructureSection load='4lhj' size='340' side='right' caption='[[4lhj]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
+<StructureSection load='4lhj' size='340' side='right'caption='[[4lhj]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[4lhj]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LHJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4LHJ FirstGlance]. <br>
+<table><tr><td colspan='2'>[[4lhj]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Ricinus_communis Ricinus communis] and [https://en.wikipedia.org/wiki/Vicugna_pacos Vicugna pacos]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LHJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4LHJ FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
-<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4lgp|4lgp]], [[4lgr|4lgr]], [[4lgs|4lgs]], [[4lhq|4lhq]]</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
-<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/rRNA_N-glycosylase rRNA N-glycosylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.2.22 3.2.2.22] </span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4lhj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4lhj OCA], [https://pdbe.org/4lhj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4lhj RCSB], [https://www.ebi.ac.uk/pdbsum/4lhj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4lhj ProSAT]</span></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4lhj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4lhj OCA], [http://pdbe.org/4lhj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4lhj RCSB], [http://www.ebi.ac.uk/pdbsum/4lhj PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4lhj ProSAT]</span></td></tr>
 </table>
 == Function ==
-[[http://www.uniprot.org/uniprot/RICI_RICCO RICI_RICCO]] Ricin is highly toxic to animal cells and to a lesser extent to plant cells. The A chain acts as a glycosidase that removes a specific adenine residue from an exposed loop of the 28S rRNA (A4324 in mammals), leading to rRNA breakage. As this loop is involved in elongation factor binding, modified ribosomes are catalytically inactive and unable to support protein synthesis. The A chain can inactivate a few thousand ribosomes per minute, faster than the cell can make new ones. Therefore a single A chain molecule can kill an animal cell. The B chain binds to beta-D-galactopyranoside moieties on cell surface glycoproteins and glycolipids and facilitates the entry into the cell of the A chain; B chains are also responsible for cell agglutination (Lectin activity).
+[https://www.uniprot.org/uniprot/RICI_RICCO RICI_RICCO] Ricin is highly toxic to animal cells and to a lesser extent to plant cells. The A chain acts as a glycosidase that removes a specific adenine residue from an exposed loop of the 28S rRNA (A4324 in mammals), leading to rRNA breakage. As this loop is involved in elongation factor binding, modified ribosomes are catalytically inactive and unable to support protein synthesis. The A chain can inactivate a few thousand ribosomes per minute, faster than the cell can make new ones. Therefore a single A chain molecule can kill an animal cell. The B chain binds to beta-D-galactopyranoside moieties on cell surface glycoproteins and glycolipids and facilitates the entry into the cell of the A chain; B chains are also responsible for cell agglutination (Lectin activity).
 <div style="background-color:#fffaf0;">
 == Publication Abstract from PubMed ==
@@ Line 22: / Line 21: @@
 ==See Also==
-*[[Ricin|Ricin]]
+*[[Antibody 3D structures|Antibody 3D structures]]
+*[[Ricin 3D structures|Ricin 3D structures]]
+*[[3D structures of non-human antibody|3D structures of non-human antibody]]
 == References ==
 <references/>
 __TOC__
 </StructureSection>
-[[Category: RRNA N-glycosylase]]
+[[Category: Large Structures]]
-[[Category: Burshteyn, F]]
+[[Category: Ricinus communis]]
-[[Category: Cassidy, M]]
+[[Category: Vicugna pacos]]
-[[Category: Cheung, J]]
+[[Category: Burshteyn F]]
-[[Category: Franklin, M]]
+[[Category: Cassidy M]]
-[[Category: Gary, E]]
+[[Category: Cheung J]]
-[[Category: Mantis, N]]
+[[Category: Franklin M]]
-[[Category: Rudolph, M J]]
+[[Category: Gary E]]
-[[Category: Hydrolase-immune system complex]]
+[[Category: Mantis N]]
-[[Category: Ribosome inhibiting protein]]
+[[Category: Rudolph MJ]]