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| <StructureSection load='3dyt' size='350' side='right' caption='Structure of human sorting nexin-9 PX domain complex with sulfate (PDB entry [[3dyt]])' scene=''> | | <StructureSection load='3dyt' size='350' side='right' caption='Structure of human sorting nexin-9 PX domain complex with sulfate (PDB entry [[3dyt]])' scene=''> |
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| | __TOC__ |
| == Function == | | == Function == |
| '''Sorting nexins''' (SNX) are proteins which enhance membrane association via their lipid-binding PX domain or via protein-protein association<ref>PMID:25619244</ref>. The PX domain contains a phospholipid-binding motif. | | '''Sorting nexins''' (SNX) are proteins which enhance membrane association via their lipid-binding PX domain or via protein-protein association<ref>PMID:25619244</ref>. The PX domain contains a phospholipid-binding motif. |
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| *'''SNX 9''' has a role in endocytosis<ref>PMID:12952949</ref>.<br /> | | *'''SNX 9''' has a role in endocytosis<ref>PMID:12952949</ref>.<br /> |
| *'''SNX 10''' induces giant vacuoles in mammalian cells<ref>PMID:17012226</ref>.<br /> | | *'''SNX 10''' induces giant vacuoles in mammalian cells<ref>PMID:17012226</ref>.<br /> |
| *'''SNX 11'''and '''SNX 17''' regulate lysosomal degradation of plasma membrane<ref>PMID:26818531</ref>.<br /> | | *'''SNX 11''' and '''SNX 17''' regulate lysosomal degradation of plasma membrane<ref>PMID:26818531</ref>.<br /> |
| *'''SNX 12''' regulates BACE1-mediated APP processing <ref>PMID:22709416</ref>.<br /> | | *'''SNX 12''' regulates BACE1-mediated APP processing <ref>PMID:22709416</ref>.<br /> |
| *'''SNX 14''' has a role in maintaining normal neuronal excitability.<br /> | | *'''SNX 14''' has a role in maintaining normal neuronal excitability.<br /> |
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| </StructureSection> | | </StructureSection> |
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| ==3D structures of sorting nexin==
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| Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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| {{#tree:id=OrganizedByTopic|openlevels=0|
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| *Sorting nexin 1
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| **[[2i4k]] – hSNX PX domain - human - NMR<br />
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| **[[4fzs]] – hSNX BAR domain <br />
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| *Sorting nexin 3
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| **[[2mxc]] – hSNX - NMR <br />
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| **[[2yps]] – hSNX PX domain <br />
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| **[[5f0j]] – hSNX PX domain + VPS26 + VPS35<br />
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| **[[5f0l]], [[5f0m]], [[5f0p]] – hSNX + VPS26 + VPS35 + DMT1 peptide<br />
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| **[[1ocs]] – ySNX PX domain – yeast<br />
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| **[[1ocu]] – ySNX PX domain + phosphatidylinositol-3-phosphate<br />
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| *Sorting nexin 5
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| **[[5tgh]], [[5tgi]], [[5wy2]] – hSNX PX domain + INCE<br />
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| **[[3hpb]], [[3hpc]] – rSNX PX domain – rat<br />
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| **[[5tp1]] – mSNX PX domain + INCE<br />
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| *Sorting nexin 7
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| **[[3iq2]] – hSNX PX domain <br />
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| *Sorting nexin 9
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| **[[2enm]] – SNX SH3 domain – mouse - NMR<br />
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| **[[2rai]], [[2raj]], [[2rak]], [[3dyt]], [[3dyu]] – hSNX PX-BAR domain <br />
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| **[[3lge]] – SNX residues 152-182 + aldolase – rabbit<br />
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| *Sorting nexin 10
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| **[[4on3]], [[4pzg]] – hSNX residues 1-201<br />
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| *Sorting nexin 11
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| **[[4ikb]], [[4ikd]] – hSNX PX domain <br />
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| *Sorting nexin 12
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| **[[2csk]] – hSNX PX domain <br />
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| *Sorting nexin 14
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| **[[4bgj]], [[4pqo]], [[4pqp]] – hSNX PX domain <br />
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| *Sorting nexin 15
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| **[[6mbi]], [[6ecm]] – hSNX PX domain <br />
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| *Sorting nexin 16
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| **[[5gw0]], [[5gw1]] – hSNX PX-coiled coll domain <br />
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| *Sorting nexin 17
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| **[[3fog]], [[3lui]] – hSNX PX domain <br />
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| **[[4gxb]], [[4tkn]] – hSNX FERM domain + NPXY motif<br />
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| *Sorting nexin 21
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| **[[4ymr]] – mSNX PX/TPR domain <br />
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| *Sorting nexin 22
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| **[[2ett]] – hSNX PX domain - NMR<br />
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| *Sorting nexin 23
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| **[[6ee0]] – hSNX PX domain <br />
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| *Sorting nexin 24
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| **[[4az9]] – hSNX PX domain <br />
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| *Sorting nexin 25
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| **[[5xdz]] – SNX PX domain - zebrafish<br />
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| **[[5woe]] – hSNX Phox hiomology domain - NMR<br />
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| *Sorting nexin 27
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| **[[4has]], [[5zn9]] – hSNX PX domain <br />
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| **[[6sak]] – hSNX PX domain + otulin<br />
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| **[[3qdo]], [[3qe1]] – rSNX PDZ domain/GIRK3 C terminal <br />
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| **[[3qgl]] – rSNX PDZ domain + GIRK3 C terminal <br />
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| **[[5elq]] – rSNX PDZ domain + DGKζ C terminal <br />
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| **[[5em9]], [[5ema]], [[5emb]], [[4z8j]] – rSNX PDZ domain + PDZ-binding motif <br />
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| **[[4p2a]] – rSNX PDZ domain + VPSA26 <br />
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| **[[4z8j]] – rSNX PDZ domain + parathyroid hormone receptor PDZ domain <br />
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| *Sorting nexin 32
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| **[[6e8r]] – hSNX PX domain + INCE<br />
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| *Sorting nexin 33
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| **[[4akv]] – hSNX PH-BAR domain <br />
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| *Sorting nexin
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| **[[3hpb]], [[3hpc]] – rSNX PX domain – rat<br />
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| }}
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| == References == | | == References == |
| <references/> | | <references/> |
| [[Category:Topic Page]] | | [[Category:Topic Page]] |