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Sorting nexin: Difference between revisions

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<StructureSection load='3dyt' size='350' side='right' caption='Structure of human sorting nexin-9 PX domain complex with sulfate (PDB entry [[3dyt]])' scene=''>
<StructureSection load='3dyt' size='350' side='right' caption='Structure of human sorting nexin-9 PX domain complex with sulfate (PDB entry [[3dyt]])' scene=''>
__TOC__
== Function ==     
== Function ==     
'''Sorting nexins''' (SNX) are proteins which enhance membrane association via their lipid-binding PX domain or via protein-protein association<ref>PMID:25619244</ref>.  The PX domain contains a phospholipid-binding motif.  
'''Sorting nexins''' (SNX) are proteins which enhance membrane association via their lipid-binding PX domain or via protein-protein association<ref>PMID:25619244</ref>.  The PX domain contains a phospholipid-binding motif.  
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*'''SNX 9''' has a role in endocytosis<ref>PMID:12952949</ref>.<br />
*'''SNX 9''' has a role in endocytosis<ref>PMID:12952949</ref>.<br />
*'''SNX 10''' induces giant vacuoles in mammalian cells<ref>PMID:17012226</ref>.<br />
*'''SNX 10''' induces giant vacuoles in mammalian cells<ref>PMID:17012226</ref>.<br />
*'''SNX 11'''and '''SNX 17''' regulate lysosomal degradation of plasma membrane<ref>PMID:26818531</ref>.<br />
*'''SNX 11''' and '''SNX 17''' regulate lysosomal degradation of plasma membrane<ref>PMID:26818531</ref>.<br />
*'''SNX 12''' regulates BACE1-mediated APP processing <ref>PMID:22709416</ref>.<br />
*'''SNX 12''' regulates BACE1-mediated APP processing <ref>PMID:22709416</ref>.<br />
*'''SNX 14''' has a role in maintaining normal neuronal excitability.<br />
*'''SNX 16''' has a role in protein transport from early to late endosomes.<br />
*'''SNX 22''', '''SNX 24''', '''SNX 25''' and '''SNX 32''' may have a role in intracellular trafficking.<br />
*'''SNX 27''' modulates synaptic plasticity<ref>PMID:25071192</ref>.<br />
*'''SNX 27''' modulates synaptic plasticity<ref>PMID:25071192</ref>.<br />
*'''SNX 33''' induces micronucleated phenotype and actin polymerization<ref>PMID:19487689</ref>.<br />
*'''SNX 33''' induces micronucleated phenotype and actin polymerization<ref>PMID:19487689</ref>.<br />
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== Relevance ==
== Relevance ==
SNX 2 is a potential marker of hyperfunctioning thyroid disorders<ref>PMID:23531855</ref>.  
SNX 2 is a potential marker of hyperfunctioning thyroid disorders<ref>PMID:23531855</ref>.  
</StructureSection>


==3D structures of sorting nexin==
==3D structures of sorting nexin==
[[Sorting nexin 3D structures]]


Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
</StructureSection>
{{#tree:id=OrganizedByTopic|openlevels=0|
 
*Sorting nexin 1
 
**[[2i4k]] – hSNX PX domain - human - NMR<br />
**[[4fzs]] – hSNX BAR domain <br />
 
*Sorting nexin 3
 
**[[1ocs]] – ySNX PX domain – yeast<br />
**[[1ocu]] – ySNX PX domain + phosphatidylinositol-3-phosphate<br />
**[[2mxc]] – hSNX - NMR <br />
**[[2yps]] – hSNX PX domain <br />
**[[5f0j]] – hSNX PX domain + VPS26 + VPS35<br />
**[[5f0l]], [[5f0m]], [[5f0p]] – hSNX + VPS26 + VPS35 + DMT1 peptide<br />
 
*Sorting nexin 5
 
**[[3hpb]], [[3hpc]] – rSNX PX domain – rat<br />
**[[5tgh]], [[5tgi]] – hSNX PX domain + INCE<br />
**[[5tp1]] – mSNX PX domain + INCE<br />
 
*Sorting nexin 7
 
**[[3iq2]] – hSNX PX domain <br />
 
*Sorting nexin 9
 
**[[2enm]] – SNX SH3 domain – mouse - NMR<br />
**[[2rai]], [[2raj]], [[2rak]], [[3dyt]], [[3dyu]] – hSNX PX-BAR domain <br />
**[[3lge]] – SNX residues 152-182 + aldolase – rabbit<br />
 
*Sorting nexin 10
 
**[[4on3]], [[4pzg]] – hSNX residues 1-201<br />
 
*Sorting nexin 11
 
**[[4ikb]], [[4ikd]] – hSNX PX domain <br />
 
*Sorting nexin 12
 
**[[2csk]] – hSNX PX domain <br />
 
*Sorting nexin 14
 
**[[4bgj]], [[4pqo]], [[4pqp]] – hSNX PX domain <br />
 
*Sorting nexin 16
 
**[[5gw0]], [[5gw1]] – hSNX PX-coiled coll domain <br />
 
*Sorting nexin 17
 
**[[3fog]], [[3lui]] – hSNX PX domain <br />
**[[4gxb]], [[4tkn]] – hSNX FERM domain + NPXY motif<br />
 
*Sorting nexin 21
 
**[[4ymr]] – mSNX PX/TPR domain <br />
 
*Sorting nexin 22
 
**[[2ett]] – hSNX PX domain - NMR<br />
 
*Sorting nexin 24
 
**[[4az9]] – hSNX PX domain <br />
 
*Sorting nexin 25
 
**[[5xdz]] – SNX PX domain - zebrafish<br />
 
*Sorting nexin 27
 
**[[3qdo]], [[3qe1]] – rSNX PDZ domain/GIRK3 C terminal  <br />
**[[3qgl]] – rSNX PDZ domain + GIRK3 C terminal  <br />
**[[5elq]] – rSNX PDZ domain + DGKζ C terminal  <br />
**[[5em9]], [[5ema]], [[5emb]], [[4z8j]] – rSNX PDZ domain + PDZ-binding motif  <br />
**[[4p2a]] – rSNX PDZ domain + VPSA26  <br />
**[[4z8j]] – rSNX PDZ domain + parathyroid hormone receptor PDZ domain  <br />
**[[4has]] – hSNX PX domain <br />
 
*Sorting nexin 33
 
**[[4akv]] – hSNX PH-BAR domain <br />
 
*Sorting nexin


**[[3hpb]], [[3hpc]] – rSNX PX domain – rat<br />
}}
== References ==
== References ==
<references/>
<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

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Michal Harel, Alexander Berchansky
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