Sorting nexin: Difference between revisions

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Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

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 <StructureSection load='3dyt' size='350' side='right' caption='Structure of human sorting nexin-9 PX domain complex with sulfate (PDB entry [[3dyt]])' scene=''>
-'''Sorting nexins''' (SNX) are proteins which enhance membrane association via their lipid-binding PX domain or via protein-protein association.  The PX domain contains a phospholipid-binding motif.
-</StructureSection>
-==3D structures of sorting nexin==
+__TOC__
+== Function ==
+'''Sorting nexins''' (SNX) are proteins which enhance membrane association via their lipid-binding PX domain or via protein-protein association<ref>PMID:25619244</ref>.  The PX domain contains a phospholipid-binding motif.
-Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
+*'''SNX 1''' regulates trafficking in the endosome compartment<ref>PMID:11997453</ref>.<br />
-{{#tree:id=OrganizedByTopic|openlevels=0|
+*'''SNX 3''' regulates neurite formation<ref>PMID:19576982</ref>.<br />
+*'''SNX 5''' regulates retrograde trafficking of transmembrane cargo receptors<ref>PMID:19553671</ref>.<br />
+*'''SNX 7''' regulates the survival of cells in embryonic liver<ref>PMID:22213104</ref>.<br />
+*'''SNX 9''' has a role in endocytosis<ref>PMID:12952949</ref>.<br />
+*'''SNX 10''' induces giant vacuoles in mammalian cells<ref>PMID:17012226</ref>.<br />
+*'''SNX 11''' and '''SNX 17''' regulate lysosomal degradation of plasma membrane<ref>PMID:26818531</ref>.<br />
+*'''SNX 12''' regulates BACE1-mediated APP processing <ref>PMID:22709416</ref>.<br />
+*'''SNX 14''' has a role in maintaining normal neuronal excitability.<br />
+*'''SNX 16''' has a role in protein transport from early to late endosomes.<br />
+*'''SNX 22''', '''SNX 24''', '''SNX 25''' and '''SNX 32''' may have a role in intracellular trafficking.<br />
+*'''SNX 27''' modulates synaptic plasticity<ref>PMID:25071192</ref>.<br />
+*'''SNX 33''' induces micronucleated phenotype and actin polymerization<ref>PMID:19487689</ref>.<br />
-*Sorting nexin 1
+== Relevance ==
+SNX 2 is a potential marker of hyperfunctioning thyroid disorders<ref>PMID:23531855</ref>.
-**[[2i4k]] – hSNX PX domain - human - NMR<br />
+==3D structures of sorting nexin==
-**[[4fzs]] – hSNX BAR domain <br />
+[[Sorting nexin 3D structures]]
-*Sorting nexin 3
+</StructureSection>
-**[[1ocs]] – ySNX PX domain – yeast<br />
-**[[1ocu]] – ySNX PX domain + phosphatidylinositol-3-phosphate<br />
-**[[2yps]] – hSNX PX domain <br />
-*Sorting nexin 5
-**[[3hpb]], [[3hpc]] – rSNX PX domain – rat<br />
-*Sorting nexin 7
-**[[3iq2]] – hSNX PX domain <br />
-*Sorting nexin 9
-**[[2enm]] – SNX SH3 domain – mouse - NMR<br />
-**[[2rai]], [[2raj]], [[2rak]], [[3dyt]], [[3dyu]] – hSNX PX-BAR domain <br />
-**[[3lge]] – SNX residues 152-182 + aldolase – rabbit<br />
-*Sorting nexin 10
-**[[4on3]], [[4pzg]] – hSNX residues 1-201<br />
-*Sorting nexin 11
-**[[4ikb]], [[4ikd]] – hSNX PX domain <br />
-*Sorting nexin 12
-**[[2csk]] – hSNX PX domain <br />
-*Sorting nexin 14
-**[[4bgj]], [[4pqo]], [[4pqp]] – hSNX PX domain <br />
-*Sorting nexin 17
-**[[3fog]], [[3lui]] – hSNX PX domain <br />
-**[[4gxb]], [[4tkh]] – hSNX FERM domain + NPXY motif<br />
-*Sorting nexin 22
-**[[2ett]] – hSNX PX domain - NMR<br />
-*Sorting nexin 24
-**[[4az9]] – hSNX PX domain <br />
-*Sorting nexin 27
-**[[3qdo]], [[3qe1]] – rSNX PDZ domain/GIRK3 C terminal  <br />
-**[[3qgl]] – rSNX PDZ domain + GIRK3 C terminal  <br />
-**[[4p2a]] – rSNX PDZ domain + VPSA26  <br />
-**[[4has]] – hSNX PX domain <br />
-*Sorting nexin 33
-**[[4akv]] – hSNX PH-BAR domain <br />
-*Sorting nexin
-**[[3hpb]], [[3hpc]] – rSNX PX domain – rat<br />
+== References ==
-}}
+<references/>
 [[Category:Topic Page]]