Sorting nexin: Difference between revisions

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New page: <StructureSection load='3dyt' size='350' side='right' caption='Structure of human sorting nexin-9 PX domain (PDB entry 3dyt)' scene=''> '''Sorting nexins''' (SNX) are proteins wh...
 
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<StructureSection load='3dyt' size='350' side='right' caption='Structure of human sorting nexin-9 PX domain complex with sulfate (PDB entry [[3dyt]])' scene=''>


<StructureSection load='3dyt' size='350' side='right' caption='Structure of human sorting nexin-9 PX domain (PDB entry [[3dyt]])' scene=''>
__TOC__
   
== Function ==  
'''Sorting nexins''' (SNX) are proteins which enhance membrane association via their lipid-binding PX domain or via protein-protein association.  The PX domain contains a phospholipid-binding motif.
'''Sorting nexins''' (SNX) are proteins which enhance membrane association via their lipid-binding PX domain or via protein-protein association<ref>PMID:25619244</ref>.  The PX domain contains a phospholipid-binding motif.  


==3D structures of sorting nexin==
*'''SNX 1''' regulates trafficking in the endosome compartment<ref>PMID:11997453</ref>.<br />
*'''SNX 3''' regulates neurite formation<ref>PMID:19576982</ref>.<br />
*'''SNX 5''' regulates retrograde trafficking of transmembrane cargo receptors<ref>PMID:19553671</ref>.<br />
*'''SNX 7''' regulates the survival of cells in embryonic liver<ref>PMID:22213104</ref>.<br />
*'''SNX 9''' has a role in endocytosis<ref>PMID:12952949</ref>.<br />
*'''SNX 10''' induces giant vacuoles in mammalian cells<ref>PMID:17012226</ref>.<br />
*'''SNX 11''' and '''SNX 17''' regulate lysosomal degradation of plasma membrane<ref>PMID:26818531</ref>.<br />
*'''SNX 12''' regulates BACE1-mediated APP processing <ref>PMID:22709416</ref>.<br />
*'''SNX 14''' has a role in maintaining normal neuronal excitability.<br />
*'''SNX 16''' has a role in protein transport from early to late endosomes.<br />
*'''SNX 22''', '''SNX 24''', '''SNX 25''' and '''SNX 32''' may have a role in intracellular trafficking.<br />
*'''SNX 27''' modulates synaptic plasticity<ref>PMID:25071192</ref>.<br />
*'''SNX 33''' induces micronucleated phenotype and actin polymerization<ref>PMID:19487689</ref>.<br />


Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
== Relevance ==
SNX 2 is a potential marker of hyperfunctioning thyroid disorders<ref>PMID:23531855</ref>.


'''SNX-1'''
==3D structures of sorting nexin==
 
[[Sorting nexin 3D structures]]
[[2i4k]] – hSNX PX domain - NMR<br />
 
'''SNX-3'''
 
[[1ocs]] – ySNX PX domain – yeast<br />
[[1ocu]] – ySNX PX domain + phosphatidylinositol-3-phosphate<br />
[[2yps]] – hSNX PX domain <br />
 
'''SNX-5'''
 
[[3hpb]], [[3hpc]] – rSNX PX domain – rat<br />
 
'''SNX-7'''
 
[[3iq2]] – hSNX PX domain <br />
 
'''SNX-9'''
 
[[2enm]] – SNX SH3 domain – mouse - NMR<br />
[[2rai]], [[2raj]], [[2rak]], [[3dyt]], [[3dyu]] – hSNX PX-BAR domain <br />
[[3lge]] – SNX residues 152-182 + aldolase – rabbit<br />
 
'''SNX-11'''
 
[[4ikb]], [[4ikd]] – hSNX PX domain <br />
 
'''SNX-12'''
 
[[2csk]] – hSNX PX domain <br />
 
'''SNX-14'''
 
[[4bgj]] – hSNX PX domain <br />
 
'''SNX-17'''
 
[[3fog]], [[3lui]] – hSNX PX domain <br />
[[4gxb]] – hSNX FERM domain + P-selectin NPXY motif<br />
 
'''SNX-22'''
 
[[2ett]] – hSNX PX domain - NMR<br />
 
'''SNX-24'''
 
[[4az9]] – hSNX PX domain <br />
 
'''SNX-27'''
 
[[3qdo]], [[3qe1]] – rSNX PDZ domain/GIRK3 C terminal  <br />
[[3qgl]] – rSNX PDZ domain + GIRK3 C terminal  <br />
[[4has]] – hSNX PX domain <br />


'''SNX-33'''
</StructureSection>


[[4akv]] – hSNX PH-BAR domain <br />
== References ==
<references/>
[[Category:Topic Page]]

Latest revision as of 13:06, 13 August 2024


Function

Sorting nexins (SNX) are proteins which enhance membrane association via their lipid-binding PX domain or via protein-protein association[1]. The PX domain contains a phospholipid-binding motif.

  • SNX 1 regulates trafficking in the endosome compartment[2].
  • SNX 3 regulates neurite formation[3].
  • SNX 5 regulates retrograde trafficking of transmembrane cargo receptors[4].
  • SNX 7 regulates the survival of cells in embryonic liver[5].
  • SNX 9 has a role in endocytosis[6].
  • SNX 10 induces giant vacuoles in mammalian cells[7].
  • SNX 11 and SNX 17 regulate lysosomal degradation of plasma membrane[8].
  • SNX 12 regulates BACE1-mediated APP processing [9].
  • SNX 14 has a role in maintaining normal neuronal excitability.
  • SNX 16 has a role in protein transport from early to late endosomes.
  • SNX 22, SNX 24, SNX 25 and SNX 32 may have a role in intracellular trafficking.
  • SNX 27 modulates synaptic plasticity[10].
  • SNX 33 induces micronucleated phenotype and actin polymerization[11].

Relevance

SNX 2 is a potential marker of hyperfunctioning thyroid disorders[12].

3D structures of sorting nexin

Sorting nexin 3D structures


Structure of human sorting nexin-9 PX domain complex with sulfate (PDB entry 3dyt)

Drag the structure with the mouse to rotate

ReferencesReferences

  1. ↑ Gallon M, Cullen PJ. Retromer and sorting nexins in endosomal sorting. Biochem Soc Trans. 2015 Feb;43(1):33-47. doi: 10.1042/BST20140290. PMID:25619244 doi:http://dx.doi.org/10.1042/BST20140290
  2. ↑ Zhong Q, Lazar CS, Tronchere H, Sato T, Meerloo T, Yeo M, Songyang Z, Emr SD, Gill GN. Endosomal localization and function of sorting nexin 1. Proc Natl Acad Sci U S A. 2002 May 14;99(10):6767-72. Epub 2002 May 7. PMID:11997453 doi:http://dx.doi.org/10.1073/pnas.092142699
  3. ↑ Mizutani R, Yamauchi J, Kusakawa S, Nakamura K, Sanbe A, Torii T, Miyamoto Y, Tanoue A. Sorting nexin 3, a protein upregulated by lithium, contains a novel phosphatidylinositol-binding sequence and mediates neurite outgrowth in N1E-115 cells. Cell Signal. 2009 Nov;21(11):1586-94. doi: 10.1016/j.cellsig.2009.06.005. Epub, 2009 Jul 2. PMID:19576982 doi:http://dx.doi.org/10.1016/j.cellsig.2009.06.005
  4. ↑ Koharudin LM, Furey W, Liu H, Liu YJ, Gronenborn AM. The phox domain of sorting nexin 5 lacks phosphatidylinositol 3-phosphate (PtdIns(3)P) specificity and preferentially binds to phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). J Biol Chem. 2009 Aug 28;284(35):23697-707. Epub 2009 Jun 24. PMID:19553671 doi:http://dx.doi.org/M109.008995
  5. ↑ Xu L, Yin W, Xia J, Peng M, Li S, Lin S, Pei D, Shu X. An antiapoptotic role of sorting nexin 7 is required for liver development in zebrafish. Hepatology. 2012 Jun;55(6):1985-93. doi: 10.1002/hep.25560. Epub 2012 Apr 23. PMID:22213104 doi:http://dx.doi.org/10.1002/hep.25560
  6. ↑ Lundmark R, Carlsson SR. Sorting nexin 9 participates in clathrin-mediated endocytosis through interactions with the core components. J Biol Chem. 2003 Nov 21;278(47):46772-81. Epub 2003 Sep 2. PMID:12952949 doi:http://dx.doi.org/10.1074/jbc.M307334200
  7. ↑ Qin B, He M, Chen X, Pei D. Sorting nexin 10 induces giant vacuoles in mammalian cells. J Biol Chem. 2006 Dec 1;281(48):36891-6. Epub 2006 Sep 29. PMID:17012226 doi:http://dx.doi.org/10.1074/jbc.M608884200
  8. ↑ Li C, Ma W, Yin S, Liang X, Shu X, Pei D, Egan TM, Huang J, Pan A, Li Z. Sorting Nexin 11 Regulates Lysosomal Degradation of Plasma Membrane TRPV3. Traffic. 2016 May;17(5):500-14. doi: 10.1111/tra.12379. Epub 2016 Feb 23. PMID:26818531 doi:http://dx.doi.org/10.1111/tra.12379
  9. ↑ Zhao Y, Wang Y, Yang J, Wang X, Zhao Y, Zhang X, Zhang YW. Sorting nexin 12 interacts with BACE1 and regulates BACE1-mediated APP processing. Mol Neurodegener. 2012 Jun 18;7:30. doi: 10.1186/1750-1326-7-30. PMID:22709416 doi:http://dx.doi.org/10.1186/1750-1326-7-30
  10. ↑ Hussain NK, Diering GH, Sole J, Anggono V, Huganir RL. Sorting Nexin 27 regulates basal and activity-dependent trafficking of AMPARs. Proc Natl Acad Sci U S A. 2014 Aug 12;111(32):11840-5. doi:, 10.1073/pnas.1412415111. Epub 2014 Jul 28. PMID:25071192 doi:http://dx.doi.org/10.1073/pnas.1412415111
  11. ↑ Zhang J, Zhang X, Guo Y, Xu L, Pei D. Sorting nexin 33 induces mammalian cell micronucleated phenotype and actin polymerization by interacting with Wiskott-Aldrich syndrome protein. J Biol Chem. 2009 Aug 7;284(32):21659-69. doi: 10.1074/jbc.M109.007278. Epub 2009, Jun 1. PMID:19487689 doi:http://dx.doi.org/10.1074/jbc.M109.007278
  12. ↑ Kanzawa M, Hara S, Semba S, Yokozaki H, Hirokawa M, Itoh T. Sorting Nexin 2 (SNX2): a potential marker of active thyrocytes in normal and hyperfunctioning thyroid disorders. Appl Immunohistochem Mol Morphol. 2014 Apr;22(4):302-7. doi:, 10.1097/PAI.0b013e31828badd3. PMID:23531855 doi:http://dx.doi.org/10.1097/PAI.0b013e31828badd3

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