Leukocyte immunoglobulin-like receptor: Difference between revisions

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Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

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 <StructureSection load='' size='350' side='right' caption='Structure of human leukocyte immunoglobulin-like receptor ligand-binding domain (salmon) complex with class I MHC (aqua), β-2 microglobulin (green) and POL polyprotein peptide (pink) (PDB entry [[1p7q]])' scene='55/552188/Cv/3'>
-'''Leukocyte immunoglobulin-like receptors''' (LIR) or '''CD85''' have extracellular immunoglobulin domains.  LIR modulates a variety of immune cells.  LIR interacts with class I MHC molecules<ref>PMID:19548123</ref>. <scene name='55/552188/Cv/4'>Leukocyte immunoglobulin-like receptor complex with class I MHC, β-2 microglobulin and POL polyprotein peptide</scene> (PDB entry [[1p7q]]). <scene name='55/552188/Cv/5'>Interactions between LIR and class I MHC, β-2 microglobulin</scene>.
+'''Leukocyte immunoglobulin-like receptors''' (LIR) or '''CD85''' have extracellular immunoglobulin domains.  LIR modulates a variety of immune cells.  LIR interacts with class I MHC molecules<ref>PMID:19548123</ref>. <scene name='55/552188/Cv/6'>Leukocyte immunoglobulin-like receptor complex with class I MHC, β-2 microglobulin and POL polyprotein peptide</scene> (PDB entry [[1p7q]]). <scene name='55/552188/Cv/7'>Interactions between LIR and class I MHC, β-2 microglobulin</scene>.
+*'''LILRA2''' is an activating receptor that inhibits dendritic cell differentiation.
+*'''LILRA5''' has a role in triggering innate immune responses.
+*'''LILRB1''' interacts with classical and non-classical human leukocyte antigen (HLA) class I molecules<ref>PMID:37781391</ref>.
+*'''LILRB3''' is a target for treatment against acute myeloid leukaemia<ref>PMID:38098451</ref>.
+*'''LILRB4''' suppresses immunity in solid tumors<ref>PMID:33974041</ref>.
+See also:
+*[[Immune receptors]]
+*[[Receptor]]
 </StructureSection>
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 {{#tree:id=OrganizedByTopic|openlevels=0|
-*LIR-1
+*LILR; ligand-binding domain D1D2 27-221; ligand-binding domain D3D4 222-417
+*LILRA2 subfamily A member 2
+**[[2otp]] – hLILRA2 ligand-binding domain D1D2 - human<br />
+*LILRA3 subfamily A member 3
+**[[3q2c]] – hLILRA3 N-terminal domain  <br />
+*LILRA5 subfamily A member 5
+**[[2d3v]] – hLILRA5 extracerllular domain  <br />
+**[[1vdg]] – hLILRA5 ligand-binding domain D1D2 (mutant) <br />
-**[[1g0x]], [[1ufu]] – hLIR-1 ligand-binding domain D1D2– human <br />
+*LILRB1 subfamily B member 1
-**[[1ugn]], [[1vdg]] – hLIR-1 ligand-binding domain D1D2 (mutant) <br />
-**[[4ll9]] – hLIR-1 ligand-binding domain D3D4 <br />
-*LIR-2
+**[[1g0x]] – hLILRB1 ligand-binding domain D1D2<br />
+**[[1ugn]] – hLILRB1 ligand-binding domain D1D2 (mutant) <br />
+**[[4ll9]] – hLILRB1 ligand-binding domain D3D4 <br />
+**[[7kfk]] – hLILRB1 ligand-binding domain D3D4 + Rifin<br />
+**[[6zdx]] – hLILRB1 ectodomain + Rifin<br />
+**[[1p7q]] – hLILRB1 ligand-binding domain D1D2 + class I MHC + β-2 microglobulin +  POL polyprotein peptide<br />
+**[[4no0]], [[5knm]], [[6aee]], [[6ewa]], [[6ewc]], [[6ewo]], [[6k60]] – hLILRB1 ligand-binding domain D1D2 + class I MHC + β-2 microglobulin +  peptide<br />
+**[[3d2u]] – hLILRB1 ligand-binding domain D1D2 + herpesvirus UL18 + β-2 microglobulin +  actin peptide<br />
-**[[4lla]] – hLIR-2 ligand-binding domain D3D4 <br />
+*LILRB2 subfamily B member 2
-**[[2otp]] – hLIR-2 ligand-binding domain D1D2 <br />
-**[[2dyp]] – hLIR-2 ligand-binding domain D1D2 + class I MHC + β-2 microglobulin +  H2A peptide<br />
-*LIR-4
+**[[4lla]] – hLILRB2 ligand-binding domain D3D4 <br />
+**[[6aed]] – hLILRB2 ligand-binding domain D1D2D3D4 (mutant)<br />
+**[[2gw5]] – hLILRB2 ligand-binding domain D1D2 <br />
+**[[6bcs]] – hLILRB2 ligand-binding domain D1D2 + benzamidine<br />
+**[[2dyp]] – hLILRB2 ligand-binding domain D1D2 + class I MHC + β-2 microglobulin +  H2A peptide<br />
-**[[3q2c]] – hLIR-4 N-terminal domain  <br />
+*LILRB3 subfamily B member 3
-*LIR-5
+**[[6grq]], [[6grs]], [[6grt]] – mLILRB3 extracellular domain 25-619 <br />
-**[[3p2t]] – hLIR-5 ligand-binding domain D1D2 <br />
+*LILRB4 subfamily B member 4
-*LIR-1 complexes
+**[[3p2t]] – hLILRB4 ligand-binding domain D1D2 <br />
+**[[6k7o]] – hLILRB4 N-terminal domain + antibody <br />
-**[[1p7q]] – hLIR-1 ligand-binding domain D1D2 + class I MHC + β-2 microglobulin +  POL polyprotein peptide<br />
-**[[5knm]] – hLIR-1 ligand-binding domain D1D2 + class I MHC + β-2 microglobulin +  peptide<br />
-**[[4no0]] – hLIR-1 ligand-binding domain D1D2 + class I MHC + β-2 microglobulin +  lymphocyte-specific protein peptide<br />
-**[[3d2u]] – hLIR-1 ligand-binding domain D1D2 + herpesvirus UL18 + β-2 microglobulin +  actin peptide<br />
 }}
 == References ==
 <references/>
 [[Category:Topic Page]]