CD59: Difference between revisions
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<StructureSection load='4bik' size='350' side='right' caption='Structure of human CD59 extracellular domain (green | <StructureSection load='4bik' size='350' side='right' caption='Structure of human CD59 extracellular domain (green) complex with intermedilysin (cyan) (PDB entry [[4bik]])' scene='55/552124/Cv/1'> | ||
== Function == | == Function == | ||
'''CD59''' ('''Cluster of Differentiation 59''') is a protein which attaches to host cells via a GPI anchor. CD59 can prevent the formation of complement membrane attack complex via binding to complement C8 or C9. | '''CD59''' ('''Cluster of Differentiation 59''') is a protein which attaches to host cells via a GPI anchor. CD59 can prevent the formation of complement membrane attack complex via binding to complement C8 or C9. <ref>PMID:1698710</ref> | ||
== Relevance == | == Relevance == | ||
| Line 12: | Line 12: | ||
== Disease == | == Disease == | ||
Mutations in CD59 causes disease involving thrombosis. | Mutations in CD59 causes disease involving thrombosis. | ||
== Structural highlights == | |||
<scene name='55/552124/Cv/2'>Human CD59 extracellular domain complex with intermedilysin</scene> <ref>PMID:23665225</ref>. | |||
</StructureSection> | |||
==3D structures of CD59== | ==3D structures of CD59== | ||
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | ||
[[1erg]], [[1erh]], [[1cdq]], [[1cdr]], [[1cds]] – hCD59 extracellular domain – human - NMR<br /> | [[1erg]], [[1erh]], [[1cdq]], [[1cdr]], [[1cds]] – hCD59 extracellular domain 26-102 – human - NMR<br /> | ||
[[2ofs]], [[2j8b]], [[2uwr]], [[2ux2]] – hCD59 extracellular domain <br /> | [[2ofs]], [[2j8b]], [[2uwr]], [[2ux2]] – hCD59 extracellular domain <br /> | ||
[[4bik]] – hCD59 extracellular domain + intermedilysin<br /> | [[8cn6]] – hCD59 extracellular domain + cyclic peptide<br /> | ||
[[4bik]], [[5imt]] – hCD59 extracellular domain + intermedilysin<br /> | |||
[[5imy]] – hCD59 extracellular domain + vaginolysin<br /> | |||
[[6zd0]] – hCD59 extracellular domain + cytolysin – Cryo EM<br /> | |||
[[8b0f]] – hCD59 extracellular domain + C5b8 – Cryo EM<br /> | |||
[[8b0g]], [[8b0h]] – hCD59 extracellular domain + C5b9 + 2C9 – Cryo EM<br /> | |||
== References == | |||
<references/> | |||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||