CD59: Difference between revisions
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<StructureSection load='4bik' size='350' side='right' caption='Structure of human CD59 extracellular domain (green | <StructureSection load='4bik' size='350' side='right' caption='Structure of human CD59 extracellular domain (green) complex with intermedilysin (cyan) (PDB entry [[4bik]])' scene='55/552124/Cv/1'> | ||
'''CD59''' ('''Cluster of Differentiation 59''') is a protein which attaches to host cells via a GPI anchor. CD59 can prevent the formation of complement membrane attack complex via binding to complement C8 or C9. | == Function == | ||
'''CD59''' ('''Cluster of Differentiation 59''') is a protein which attaches to host cells via a GPI anchor. CD59 can prevent the formation of complement membrane attack complex via binding to complement C8 or C9. <ref>PMID:1698710</ref> | |||
== Relevance == | |||
HIV, vaccinia and cytomegalovirus incorporate human CD59 into their envelope thus preventing their lysis by complement. | |||
== Disease == | |||
Mutations in CD59 causes disease involving thrombosis. | |||
== Structural highlights == | |||
<scene name='55/552124/Cv/2'>Human CD59 extracellular domain complex with intermedilysin</scene> <ref>PMID:23665225</ref>. | |||
</StructureSection> | |||
==3D structures of CD59== | ==3D structures of CD59== | ||
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | ||
[[1erg]], [[1erh]], [[1cdq]], [[1cdr]], [[1cds]] – hCD59 extracellular domain – human - NMR<br /> | [[1erg]], [[1erh]], [[1cdq]], [[1cdr]], [[1cds]] – hCD59 extracellular domain 26-102 – human - NMR<br /> | ||
[[2ofs]], [[2j8b]], [[2uwr]], [[2ux2]] – hCD59 extracellular domain <br /> | [[2ofs]], [[2j8b]], [[2uwr]], [[2ux2]] – hCD59 extracellular domain <br /> | ||
[[4bik]] – hCD59 extracellular domain + intermedilysin<br /> | [[8cn6]] – hCD59 extracellular domain + cyclic peptide<br /> | ||
[[4bik]], [[5imt]] – hCD59 extracellular domain + intermedilysin<br /> | |||
[[5imy]] – hCD59 extracellular domain + vaginolysin<br /> | |||
[[6zd0]] – hCD59 extracellular domain + cytolysin – Cryo EM<br /> | |||
[[8b0f]] – hCD59 extracellular domain + C5b8 – Cryo EM<br /> | |||
[[8b0g]], [[8b0h]] – hCD59 extracellular domain + C5b9 + 2C9 – Cryo EM<br /> | |||
== References == | |||
<references/> | |||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Latest revision as of 11:54, 20 January 2025
FunctionCD59 (Cluster of Differentiation 59) is a protein which attaches to host cells via a GPI anchor. CD59 can prevent the formation of complement membrane attack complex via binding to complement C8 or C9. [1] RelevanceHIV, vaccinia and cytomegalovirus incorporate human CD59 into their envelope thus preventing their lysis by complement. DiseaseMutations in CD59 causes disease involving thrombosis. Structural highlights[2]. |
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3D structures of CD593D structures of CD59
Updated on 20-January-2025
1erg, 1erh, 1cdq, 1cdr, 1cds – hCD59 extracellular domain 26-102 – human - NMR
2ofs, 2j8b, 2uwr, 2ux2 – hCD59 extracellular domain
8cn6 – hCD59 extracellular domain + cyclic peptide
4bik, 5imt – hCD59 extracellular domain + intermedilysin
5imy – hCD59 extracellular domain + vaginolysin
6zd0 – hCD59 extracellular domain + cytolysin – Cryo EM
8b0f – hCD59 extracellular domain + C5b8 – Cryo EM
8b0g, 8b0h – hCD59 extracellular domain + C5b9 + 2C9 – Cryo EM
ReferencesReferences
- ↑ Meri S, Morgan BP, Davies A, Daniels RH, Olavesen MG, Waldmann H, Lachmann PJ. Human protectin (CD59), an 18,000-20,000 MW complement lysis restricting factor, inhibits C5b-8 catalysed insertion of C9 into lipid bilayers. Immunology. 1990 Sep;71(1):1-9. PMID:1698710
- ↑ Johnson S, Brooks NJ, Smith RA, Lea SM, Bubeck D. Structural Basis for Recognition of the Pore-Forming Toxin Intermedilysin by Human Complement Receptor CD59. Cell Rep. 2013 May 30;3(5):1369-77. doi: 10.1016/j.celrep.2013.04.029. Epub 2013 , May 9. PMID:23665225 doi:10.1016/j.celrep.2013.04.029