4kvm: Difference between revisions

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 ==The NatA (Naa10p/Naa15p) amino-terminal acetyltransferase complex bound to a bisubstrate analog==
-<StructureSection load='4kvm' size='340' side='right' caption='[[4kvm]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
+<StructureSection load='4kvm' size='340' side='right'caption='[[4kvm]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[4kvm]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Fission_yeast Fission yeast]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KVM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4KVM FirstGlance]. <br>
+<table><tr><td colspan='2'>[[4kvm]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Schizosaccharomyces_pombe_972h- Schizosaccharomyces pombe 972h-] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KVM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4KVM FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1XE:[5-(6-AMINO-9H-PURIN-9-YL)-4-HYDROXY-3-(PHOSPHONOOXY)FURAN-2-YL]METHYL+(3R)-4-{[3-({(E)-2-[(2,2-DIHYDROXYETHYL)SULFANYL]ETHENYL}AMINO)-3-OXOPROPYL]AMINO}-3-HYDROXY-2,2-DIMETHYL-4-OXOBUTYL+DIHYDROGEN+DIPHOSPHATE'>1XE</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.597&#8491;</td></tr>
-<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=LIG:3-PYRIDIN-4-YL-2,4-DIHYDRO-INDENO[1,2-.C.]PYRAZOLE'>LIG</scene></td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1XE:[[5-(6-aminopurin-9-yl)-4-oxidanyl-3-phosphonooxy-furan-2-yl]methoxy-oxidanyl-phosphoryl]+[(3R)-4-[[3-[[(E)-2-[2,2-bis(oxidanyl)ethylsulfanyl]ethenyl]amino]-3-oxidanylidene-propyl]amino]-2,2-dimethyl-3-oxidanyl-4-oxidanylidene-butyl]+hydrogen+phosphate'>1XE</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4kvo|4kvo]], [[4kvx|4kvx]]</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4kvm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kvm OCA], [https://pdbe.org/4kvm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4kvm RCSB], [https://www.ebi.ac.uk/pdbsum/4kvm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4kvm ProSAT]</span></td></tr>
-<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">nat1, SPCC338.07c ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=284812 Fission yeast]), ard1, SPAC15E1.08 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=284812 Fission yeast])</td></tr>
-<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Peptide_alpha-N-acetyltransferase Peptide alpha-N-acetyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.88 2.3.1.88] </span></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4kvm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kvm OCA], [http://pdbe.org/4kvm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4kvm RCSB], [http://www.ebi.ac.uk/pdbsum/4kvm PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4kvm ProSAT]</span></td></tr>
 </table>
 == Function ==
-[[http://www.uniprot.org/uniprot/NAT1_SCHPO NAT1_SCHPO]] Non-catalytic component of the NatA N-terminal acetyltransferase, which catalyzes acetylation of proteins beginning with Met-Ser, Met-Gly and Met-Ala. N-acetylation plays a role in normal eukaryotic translation and processing, protect against proteolytic degradation and protein turnover. nat1 anchors ard1 and nat5 to the ribosome and may present the N termini of nascent polypeptides for acetylation (By similarity). [[http://www.uniprot.org/uniprot/ARD1_SCHPO ARD1_SCHPO]] Catalytic component of the NatA N-terminal acetyltransferase, which catalyzes acetylation of proteins beginning with Met-Ser, Met-Gly and Met-Ala. N-acetylation plays a role in normal eukaryotic translation and processing, protect against proteolytic degradation and protein turnover (By similarity).
+[https://www.uniprot.org/uniprot/NAT1_SCHPO NAT1_SCHPO] Non-catalytic component of the NatA N-terminal acetyltransferase, which catalyzes acetylation of proteins beginning with Met-Ser, Met-Gly and Met-Ala. N-acetylation plays a role in normal eukaryotic translation and processing, protect against proteolytic degradation and protein turnover. nat1 anchors ard1 and nat5 to the ribosome and may present the N termini of nascent polypeptides for acetylation (By similarity).
 <div style="background-color:#fffaf0;">
 == Publication Abstract from PubMed ==
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 __TOC__
 </StructureSection>
-[[Category: Fission yeast]]
+[[Category: Large Structures]]
-[[Category: Peptide alpha-N-acetyltransferase]]
+[[Category: Schizosaccharomyces pombe 972h-]]
-[[Category: Liszczak, G P]]
+[[Category: Synthetic construct]]
-[[Category: Marmorstein, R Q]]
+[[Category: Liszczak GP]]
-[[Category: Acetyltransferase]]
+[[Category: Marmorstein RQ]]
-[[Category: Amino-terminal acetylation]]
-[[Category: Tpr repeat]]
-[[Category: Transferase-transferase inhibitor complex]]