4bps: Difference between revisions
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==Crystal structure of Chorismatase at 1.08 Angstrom resolution.== | ==Crystal structure of Chorismatase at 1.08 Angstrom resolution.== | ||
<StructureSection load='4bps' size='340' side='right' caption='[[4bps]], [[Resolution|resolution]] 1.08Å' scene=''> | <StructureSection load='4bps' size='340' side='right'caption='[[4bps]], [[Resolution|resolution]] 1.08Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4bps]] is a 1 chain structure with sequence from [ | <table><tr><td colspan='2'>[[4bps]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptomyces_hygroscopicus_subsp._ascomyceticus Streptomyces hygroscopicus subsp. ascomyceticus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BPS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4BPS FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.081Å</td></tr> | ||
<tr id=' | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3EB:3-(2-CARBOXYETHYL)BENZOIC+ACID'>3EB</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4bps FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bps OCA], [https://pdbe.org/4bps PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4bps RCSB], [https://www.ebi.ac.uk/pdbsum/4bps PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4bps ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/FKBO_STRHY FKBO_STRHY] Involved in the biosynthesis of the macrocyclic amino acid-linked polyketides FK506 and FK520 which are potent immunosuppressants that prevent T-cell proliferation through initial binding to the immunophilin FKBP12. Catalyzes the hydrolysis of chorismate via a 1,4-conjugate elimination of water to yield (4R,5R)-4,5-dihydroxycyclohexa-1,5-dienecarboxylic acid (DCDC).<ref>PMID:21383123</ref> <ref>PMID:24036425</ref> | |||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
<div class="pdbe-citations 4bps" style="background-color:#fffaf0;"></div> | |||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | |||
[[Category: Streptomyces hygroscopicus subsp. ascomyceticus]] | [[Category: Streptomyces hygroscopicus subsp. ascomyceticus]] | ||
[[Category: Andexer | [[Category: Andexer JN]] | ||
[[Category: | [[Category: Diederichs K]] | ||
[[Category: Hubrich | [[Category: Hubrich F]] | ||
[[Category: Juneja | [[Category: Juneja P]] | ||
[[Category: Welte | [[Category: Welte W]] | ||