Fibroblast growth factor: Difference between revisions
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* '''FGF2''' is called basic FGF.<br /> | * '''FGF2''' is called basic FGF.<br /> | ||
* '''FGF4''' has multiple roles during vertebrate embryogenesis<ref>PMID:18792115</ref>.<br /> | * '''FGF4''' has multiple roles during vertebrate embryogenesis<ref>PMID:18792115</ref>.<br /> | ||
* '''FGF7''' is called keratinocyte growth factor which is present in the epitheliazation-phase of wound healing when keratinocytes are covering the wound<ref>PMID:11052999</ref>. FGF7 is aparacrine growth factor in the breast<ref>PMID:12697038</ref>. | * '''FGF7''' is called '''keratinocyte growth factor''' which is present in the epitheliazation-phase of wound healing when keratinocytes are covering the wound<ref>PMID:11052999</ref>. FGF7 is aparacrine growth factor in the breast<ref>PMID:12697038</ref>. | ||
* '''FGF8''' has multiple roles in the regulation of embryogenesis, cell differentiation, proliferation and migration. It is required for normal development of normal brain, eye, ear and limb<ref>PMID:22273727</ref>.<br /> | * '''FGF8''' has multiple roles in the regulation of embryogenesis, cell differentiation, proliferation and migration. It is required for normal development of normal brain, eye, ear and limb<ref>PMID:22273727</ref>.<br /> | ||
* '''FGF9''' is produced and secreted by the prostatic stromal cells<ref>PMID:10362017</ref>.<br /> | * '''FGF9''' is produced and secreted by the prostatic stromal cells<ref>PMID:10362017</ref>.<br /> | ||
* '''FGF10''' has essential role in the growth of fetal prostate <ref>PMID:12941620</ref>.<br /> | * '''FGF10''' has essential role in the growth of fetal prostate <ref>PMID:12941620</ref>.<br /> | ||
* '''FGF12''' is a key regulator of the vascular smooth muscle cell phenotype switch<ref>PMID:27470512</ref>.<br /> | * '''FGF12''' is a key regulator of the vascular smooth muscle cell phenotype switch<ref>PMID:27470512</ref>.<br /> | ||
* '''FGF13''' regulates proliferation and differentiation of the skeletal muscle cells <ref>PMID:26230950</ref>.<br /> | |||
* '''FGF18''' has al role in organ development and damage repair <ref>PMID:36871047</ref>.<br /> | |||
* '''FGF19''' has high affinity to FGFR4<ref>PMID:10525310</ref>.<br /> | |||
* '''FGF21''' has a role in regulating body weight in a dietary carbohydrate-dependent manner <ref>PMID:37030441</ref>.<br /> | |||
* '''FGF23''' is produced by bone cells and regulates renal phosphate and vitamin D metabolism <ref>PMID:29760049</ref>.<br /> | |||
See also [[Fibroblast growth factor receptor]] and [[Growth factors]]. | |||
== Disease == | |||
Mutations in '''FGF20''' are associated with Parkinson's disease<ref>PMID:2823</ref>. | |||
== Relevance == | == Relevance == | ||
'''FGF''' signaling is important in the pathogenesis of a variety of tumor types<ref>PMID:20094046</ref>, angiogenesis<ref>PMID:7542215</ref> and wound healing<ref>PMID:12696985</ref>. '''FGF1''' is a potentially safw candidate for restoring euglycaemia without causing a=overt adverse effects<ref>PMID:28664920</ref>. Overexpression of the high molecular weight isoform of '''FGF2''' in bone results in catabolic activity in joint cartilage and bone that leads to osteoarthropathy<ref>PMID:27732085</ref>. '''FGF12''' could be a therapeutic target for treating restenosis and atherosclerosis. | '''FGF''' signaling is important in the pathogenesis of a variety of tumor types<ref>PMID:20094046</ref>, angiogenesis<ref>PMID:7542215</ref> and wound healing<ref>PMID:12696985</ref>. '''FGF1''' is a potentially safw candidate for restoring euglycaemia without causing a=overt adverse effects<ref>PMID:28664920</ref>. Overexpression of the high molecular weight isoform of '''FGF2''' in bone results in catabolic activity in joint cartilage and bone that leads to osteoarthropathy<ref>PMID:27732085</ref>. '''FGF12''' could be a therapeutic target for treating restenosis and atherosclerosis. '''FGF18''' is overexpressed in ovarian cancer and hence may serve as therapeutic target<ref>PMID:24018557</ref>. '''FGF19''' is overexpressed in lung squamous cell carcinoma and hence may serve as therapeutic target<ref>PMID:28906590</ref>. | ||
== Structural insights == | == Structural insights == | ||
<scene name='54/544711/Cv/ | <scene name='54/544711/Cv/3'>The heparin binds in the dimer interface of the rat fibroblast growth factor 1</scene><ref>PMID:18540049</ref>. Water molecules are shown as red spheres. | ||
==3D structures of fibroblast growth factor== | ==3D structures of fibroblast growth factor== | ||
[[Fibroblast growth factor 3D structures]] | |||
</StructureSection> | |||
== References == | == References == | ||
<references/> | <references/> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||