Fibroblast growth factor: Difference between revisions

← Older edit

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

@@ Line 1: / Line 1: @@
-{{STRUCTURE_2uus|  PDB=2uus  | SIZE=400| SCENE= |right|CAPTION= Rat fibroblast growth factor 1 complex with heparan sulfate, [[2uus]] }}
+<StructureSection load='2uus' size='350' side='right' scene='54/544711/Cv/1' caption='Rat fibroblast growth factor 1 complex with heparan sulfate (PDB code [[2uus]]) '>
+__TOC__
+== Function ==
+'''Fibroblast growth factors''' (FGF) are involved in angiogenesis, wound-healing and embryonic development.  FGF is heparin-binding protein.  FGF require heparan sulfate (HS) to activate the four FGF cell-surface receptors (FGFR).  In vertebrates there are 23 members in the FGF family<ref>PMID:11276432</ref>. <br />
+*  '''FGF1''' is called acidic FGF.<br />
+*  '''FGF2''' is called basic FGF.<br />
+*  '''FGF4''' has multiple roles during vertebrate embryogenesis<ref>PMID:18792115</ref>.<br />
+*  '''FGF7''' is called '''keratinocyte growth factor''' which is present in the epitheliazation-phase of wound healing when keratinocytes are covering the wound<ref>PMID:11052999</ref>.  FGF7 is aparacrine growth factor in the breast<ref>PMID:12697038</ref>.
+*  '''FGF8''' has multiple roles in the regulation of embryogenesis, cell differentiation, proliferation and migration.  It is required for normal development of normal brain, eye, ear and limb<ref>PMID:22273727</ref>.<br />
+*  '''FGF9''' is produced and secreted by the prostatic stromal cells<ref>PMID:10362017</ref>.<br />
+*  '''FGF10''' has essential role in the growth of fetal prostate <ref>PMID:12941620</ref>.<br />
+*  '''FGF12''' is a key regulator of the vascular smooth muscle cell phenotype switch<ref>PMID:27470512</ref>.<br />
+*  '''FGF13''' regulates proliferation and differentiation of the skeletal muscle cells <ref>PMID:26230950</ref>.<br />
+*  '''FGF18''' has al role in organ development and damage repair <ref>PMID:36871047</ref>.<br />
+*  '''FGF19''' has high affinity to FGFR4<ref>PMID:10525310</ref>.<br />
+*  '''FGF21''' has a role in regulating body weight in a dietary carbohydrate-dependent manner <ref>PMID:37030441</ref>.<br />
+*  '''FGF23''' is produced by bone cells and regulates renal phosphate and vitamin D metabolism <ref>PMID:29760049</ref>.<br />
+See also [[Fibroblast growth factor receptor]] and [[Growth factors]].
+== Disease ==
-'''Fibroblast growth factors''' (FGF) are involved in angiogenesis, wound-healing and embryonic development.  FGF is heparin-binding protein.  FGF require heparan sulfate (HS) to activate the four FGF cell-surface receptors (FGFR).  In vertebrates there are 23 members in the FGF family.  FGF signaling is important in the pathogenesis of a variety of tumor types.  FGF1 is called acidic FGF while FGF2 is called basic FGF.  FGF7 is called keratinocyte growth factor which is present in the eiptheliazation-phase of wound healing when keratinocytes are covering the wound.
+Mutations in '''FGF20''' are associated with Parkinson's disease<ref>PMID:2823</ref>.
-==3D structures of fibroblast growth factor==
+== Relevance ==
-Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
+'''FGF''' signaling is important in the pathogenesis of a variety of tumor types<ref>PMID:20094046</ref>, angiogenesis<ref>PMID:7542215</ref> and wound healing<ref>PMID:12696985</ref>.  '''FGF1''' is a potentially safw candidate for restoring euglycaemia without causing a=overt adverse effects<ref>PMID:28664920</ref>.  Overexpression of the high molecular weight isoform of '''FGF2''' in bone results in catabolic activity in joint cartilage and bone that leads to osteoarthropathy<ref>PMID:27732085</ref>.  '''FGF12''' could be a therapeutic target for treating restenosis and atherosclerosis. '''FGF18''' is overexpressed in ovarian cancer and hence may serve as therapeutic target<ref>PMID:24018557</ref>.  '''FGF19''' is overexpressed in lung squamous cell carcinoma and hence may serve as therapeutic target<ref>PMID:28906590</ref>.
-===FGF1===
+== Structural insights ==
-[[1fmm]] – FGF1 – ''Notophthalmus viridescens'' - NMR  <br />
+<scene name='54/544711/Cv/3'>The heparin binds in the dimer interface of the rat fibroblast growth factor 1</scene><ref>PMID:18540049</ref>. Water molecules are shown as red spheres.
-[[1afc]] – bFGF1 + HS – bovine<br />
-[[1bar]] – bFGF1   <br />
-[[2j3p]] – rFGF1  - rat<br />
-[[3hal]] – FGF1 - rabbit  <br />
-[[2afg]], [[1jqz]], [[1rg8]] – hFGF1 - human <br />
-[[1jt3]], [[1jt4]], [[1jt5]], [[1jt7]], [[1jtc]], [[1k5u]], [[1k5v]], [[1m16]], [[1jy0]], [[1nzk]], [[1p63]], [[1pzz]], [[1q03]], [[1q04]], [[1yto]], [[1z2v]], [[1z4s]], [[2aqz]], [[2hw9]], [[2hwa]], [[2hwm]], [[2hz9]], [[2ntd]], [[3b9u]], [[3ba4]], [[3ba5]], [[3ba7]], [[3bad]], [[3bag]], [[3bah]], [[3bao]], [[3baq]], [[3bau]], [[3bav]], [[3bb2]], [[2q9x]], [[3crg]], [[3crh]], [[3cri]], [[3cqa]], [[3fgm]], [[3fj8]], [[3fj9]], [[3fja]], [[3fjb]], [[3fjc]], [[3fjd]], [[3fje]], [[3fjf]], [[3fjh]], [[3fji]], [[3fjj]], [[3fjk]], [[3hom]], [[3o3q]] – hFGF1 (mutant)  <br />
-[[1dzd]], [[2rq9]] – hFGF1 - NMR  <br />
-[[1dzc]] – hFGF1 (mutant) - NMR  <br />
-''FGF1 complex with small molecule''
+==3D structures of fibroblast growth factor==
+[[Fibroblast growth factor 3D structures]]
-[[1axm]], [[2axm]] – hFGF1  + HS <br />
-[[3ud7]], [[3ud8]], [[3ud9]], [[3uda]] – hFGF1 + disaccharide  <br />
-[[2uus]] – rFGF1  + HS <br />
-[[2erm]] – hFGF1  + HS - NMR<br />
-[[1rml]] – hFGF1  + naphthalene trisulphonate - NMR  <br />
-[[1hkn]] – hFGF1  + naphthalene trisulphonate  <br />
-[[2k8r]] – hFGF1  + anti-angiogenic drug - NMR<br />
-[[3k1x]] – hFGF1  + vasoprotectant drug <br />
-[[3jut]] – hFGF1  + inhibitor  <br />
-[[2ki4]], [[2ki6]] – hFGF1  + S100-A13<br />
-''FGF1 complex with FGF receptor''
-[[1e0o]] – hFGF1 (mutant) + hFGFR2 (mutant) + HS<br />
-[[3oj2]], [[3ojm]] – hFGF1 + hFGFR2 (mutant) <br />
-[[3ojv]] – hFGF1 + hFGFR1 (mutant) <br />
-[[1ry7]] – hFGF1 + hFGFR3<br />
-[[3cu1]] – hFGF1 + hFGFR2<br />
-===FGF2===
-[[2fgf]] – hFGF2 precursor <br />
-[[1fga]], [[4fgf]], [[1bas]], [[1bfg]], [[1bfh]], [[1bff]] – hFGF2   <br />
-[[1wvz]], [[2k43]], [[2k4a]] – hFGF2 - NMR  <br />
-[[1bla]], [[1bld]] – hFGF2 (mutant) - NMR  <br />
-[[1bfb]], [[1bfc]] – hFGF2  + heparin <br />
-[[1cvs]] – hFGF2 (mutant) + hFGFR1 (mutant) <br />
-[[1fq9]] – hFGF2 (mutant) + hFGFR1 (mutant) + HS<br />
-===FGF4===
-[[1ijt]] – hFGF4 b-trefoil domain <br />
-===FGF7===
-[[1qqk]] – rFGF7  <br />
-[[1qql]] – rFGF7/hFGF1 <br />
-===FGF8===
-[[2fdb]] – hFGF8b + hFGFR2  <br />
-===FGF9===
-[[1g82]], [[1ihk]] – hFGF9  <br />
-===FGF10===
-[[1nun]] – hFGF10 + hFGFR2  <br />
-===FGF12===
-[[1q1u]] – hFGF12 (mutant)  <br />
-===FGF13===
-[[3hbw]] – hFGF13  <br />
-[[4dck]] – hFGF13 + calmodulin + sodium channel subunit α <br />
-===FGF19===
-[[1pwa]], [[2p23]] – hFGF19  <br />
-===FGF20===
-[[3f1r]] – hFGF20  <br />
+</StructureSection>
-===FGF23===
+== References ==
+<references/>
-[[2p39]] – hFGF23  <br />
 [[Category:Topic Page]]