4jo7: Difference between revisions

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 ==Crystal structure of the human Nup49CCS2+3* Nup57CCS3* complex with 2:2 stoichiometry==
-<StructureSection load='4jo7' size='340' side='right' caption='[[4jo7]], [[Resolution|resolution]] 1.75&Aring;' scene=''>
+<StructureSection load='4jo7' size='340' side='right'caption='[[4jo7]], [[Resolution|resolution]] 1.75&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[4jo7]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JO7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4JO7 FirstGlance]. <br>
+<table><tr><td colspan='2'>[[4jo7]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JO7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4JO7 FirstGlance]. <br>
-</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.752&#8491;</td></tr>
-<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4jnu|4jnu]], [[4jnv|4jnv]], [[4jo9|4jo9]], [[4jq5|4jq5]]</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4jo7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jo7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4jo7 RCSB], [http://www.ebi.ac.uk/pdbsum/4jo7 PDBsum]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4jo7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jo7 OCA], [https://pdbe.org/4jo7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4jo7 RCSB], [https://www.ebi.ac.uk/pdbsum/4jo7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4jo7 ProSAT]</span></td></tr>
 </table>
-== Function ==
+<div style="background-color:#fffaf0;">
-[[http://www.uniprot.org/uniprot/NUP54_HUMAN NUP54_HUMAN]] Component of the nuclear pore complex, a complex required for the trafficking across the nuclear membrane. [[http://www.uniprot.org/uniprot/NUPL1_HUMAN NUPL1_HUMAN]] Component of the nuclear pore complex, a complex required for the trafficking across the nuclear membrane (By similarity).
+== Publication Abstract from PubMed ==
+The nuclear pore complex (NPC) constitutes the sole gateway for bidirectional nucleocytoplasmic transport. We present the reconstitution and interdisciplinary analyses of the ~425-kDa inner ring complex (IRC), which forms the central transport channel and diffusion barrier of the NPC, revealing its interaction network and equimolar stoichiometry. The Nsp1*Nup49*Nup57 channel nucleoporin hetero-trimer (CNT) attaches to the IRC solely through the adaptor nucleoporin Nic96. The CNT*Nic96 structure reveals that Nic96 functions as an assembly sensor that recognizes the three dimensional architecture of the CNT, thereby mediating the incorporation of a defined CNT state into the NPC. We propose that the IRC adopts a relatively rigid scaffold that recruits the CNT to primarily form the diffusion barrier of the NPC, rather than enabling channel dilation.
+Architecture of the fungal nuclear pore inner ring complex.,Stuwe T, Bley CJ, Thierbach K, Petrovic S, Schilbach S, Mayo DJ, Perriches T, Rundlet EJ, Jeon YE, Collins LN, Huber FM, Lin DH, Paduch M, Koide A, Lu V, Fischer J, Hurt E, Koide S, Kossiakoff AA, Hoelz A Science. 2015 Aug 27. pii: aac9176. PMID:26316600<ref>PMID:26316600</ref>
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+</div>
+<div class="pdbe-citations 4jo7" style="background-color:#fffaf0;"></div>
 ==See Also==
-*[[Nucleoporin|Nucleoporin]]
+*[[Nucleoporin 3D structures|Nucleoporin 3D structures]]
+== References ==
+<references/>
 __TOC__
 </StructureSection>
-[[Category: Bley, C J]]
+[[Category: Homo sapiens]]
-[[Category: Hoelz, A]]
+[[Category: Large Structures]]
-[[Category: Mayo, D J]]
+[[Category: Bley CJ]]
-[[Category: Stuwe, T]]
+[[Category: Hoelz A]]
-[[Category: Nucleocytoplasmic transport]]
+[[Category: Mayo DJ]]
-[[Category: Transport protein]]
+[[Category: Stuwe T]]