Circadian clock protein: Difference between revisions

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<StructureSection load='1r8j' size='350' side='right' caption='Circadian clock protein KaiA (PDB entry [[1r8j]])' scene='53/536683/Cv/1'>
<StructureSection load='' size='350' side='right' caption='Circadian clock protein KaiA (PDB entry [[1r8j]])' scene='53/536683/Cv/1'>


'''Circadian clock proteins''' measure out the 24 hour circadian rhythm.  In cyanobacteria protein KaiA<ref>PMID:15007067</ref> stimulates KaiC<ref>PMID:15304218</ref> which adds phosphate groups to itself.  Then KaiC binds to KaiB<ref>PMID:15716247</ref> which inactivates KaiA and causes the number of phosphate groups on KaiC to drop slowly.  KaiB disconnects allowing KaiA to start the cycle again.<ref>PMID:11687489</ref>  For details of KaiC see [[Circadian Clock Protein KaiC]].
'''Circadian clock proteins''' or '''Circadian clock protein kinase''' measure out the 24 hour circadian rhythm.  In cyanobacteria protein '''KaiA'''<ref>PMID:15007067</ref> stimulates '''KaiC'''<ref>PMID:15304218</ref> which adds phosphate groups to itself.  Then '''KaiC''' binds to '''KaiB'''<ref>PMID:15716247</ref> which inactivates '''KaiA''' and causes the number of phosphate groups on '''KaiC''' to drop slowly.  '''KaiB''' disconnects allowing '''KaiA''' to start the cycle again.<ref>PMID:11687489</ref>  For details of '''KaiC''' see [[Circadian Clock Protein KaiC]].
 
Circadian clock protein KaiA from ''Synechococcus elongatus'' is <scene name='53/536683/Cv/2'>homodimer</scene> (PDB entry [[1r8j]]).


Circadian clock protein KaiA from [[Synechococcus elongatus]] is <scene name='53/536683/Cv/2'>homodimer</scene> (PDB entry [[1r8j]]).<ref>PMID:15007067</ref>
</StructureSection>
== 3D Structures of circadian clock protein ==
== 3D Structures of circadian clock protein ==
[[Circadian clock protein 3D structures]]


Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
</StructureSection>
{{#tree:id=OrganizedByTopic|openlevels=0|
 
*KaiA
 
**[[1r5q]] – NoKaiA - Nostoc<br />
**[[1m2e]], [[1m2f]] – SeKaiA N terminal – ''Synechococcus elongatus'' - NMR <br />
**[[1q6a]], [[1q6b]] – SeKaiA C terminal - NMR <br />
**[[1v2z]] – SeKaiA C terminal  <br />
**[[1r8j]] – SeKaiA  <br />
**[[1suy]], [[1sv1]] – SeKaiA C terminal + KaiC peptide - NMR <br />
**[[4g86]] – SeKaiA + DBMIB<br />
 
*KaiB
 
**[[1r5p]] – NoKaiB <br />
**[[1wwj]] – SyKaiB - ''Synechocystis''<br />
**[[1vgl]], [[2qke]], [[4kso]] – SeKaiB <br />
 
*KaiC


**[[1tf7]], [[2gbl]] – SyKaiC <br />
**[[1u9i]], [[3dvl]], [[3jzm]], [[3k09]], [[3k0a]], [[3k0c]], [[3k0e]], [[3k0f]], [[3s1a]], [[4dug]], [[4ijm]] – SeKaiC (mutant)  <br />
}}
== References ==
== References ==
<references/>
<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

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Michal Harel, Alexander Berchansky, Joel L. Sussman