Circadian clock protein: Difference between revisions

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Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

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-[[Image:2gbl.png|left|200px|thumb|Circadian clock protein KaiC [[2gbl]]]]
+<StructureSection load='' size='350' side='right' caption='Circadian clock protein KaiA (PDB entry [[1r8j]])' scene='53/536683/Cv/1'>
-{{STRUCTURE_1r8j|  PDB=1r8j  | SIZE=400| SCENE= |right|CAPTION=Circadian clock protein KaiC hexamer complex with ATP [[1r8j]] }}
+'''Circadian clock proteins''' or '''Circadian clock protein kinase''' measure out the 24 hour circadian rhythm.  In cyanobacteria protein '''KaiA'''<ref>PMID:15007067</ref> stimulates '''KaiC'''<ref>PMID:15304218</ref> which adds phosphate groups to itself.  Then '''KaiC''' binds to '''KaiB'''<ref>PMID:15716247</ref> which inactivates '''KaiA''' and causes the number of phosphate groups on '''KaiC''' to drop slowly.  '''KaiB''' disconnects allowing '''KaiA''' to start the cycle again.<ref>PMID:11687489</ref>  For details of '''KaiC''' see [[Circadian Clock Protein KaiC]].
+Circadian clock protein KaiA from ''Synechococcus elongatus'' is <scene name='53/536683/Cv/2'>homodimer</scene> (PDB entry [[1r8j]]).
-'''Circadian clock proteins''' measure out the 24 hour circadian rhythm.  In cyanobacteria protein KaiA stimulates KaiC which adds phosphate groups to itself.  Then KaiC binds to KaiB which inactivates KaiA and causes the number of phosphate groups on KaiC to drop slowly.  KaiB disconnects allowing KaiA to start the cycle again.  For details of KaiC see [[Circadian Clock Protein KaiC]].
 == 3D Structures of circadian clock protein ==
+[[Circadian clock protein 3D structures]]
-Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
+</StructureSection>
-===KaiA===
-[[1r5q]] – NoKaiA - Nostoc<br />
-[[1m2e]], [[1m2f]] – SeKaiA N terminal – ''Synechococcus elongatus'' - NMR <br />
-[[1q6a]], [[1q6b]] – SeKaiA C terminal - NMR <br />
-[[1v2z]] – SeKaiA C terminal  <br />
-[[1r8j]] – SeKaiA  <br />
-[[1suy]], [[1sv1]] – SeKaiA C terminal + KaiC peptide - NMR <br />
-[[4g86]] – SeKaiA + DBMIB<br />
-===KaiB===
-[[1r5q]] – NoKaiB <br />
-[[1wwj]] – SyKaiB - ''Synechocystis''<br />
-[[1vgl]], [[2qke]] – SeKaiB <br />
-===KaiC===
-[[1tf7]], [[2gbl]] – SyKaiC <br />
+== References ==
-[[1u9i]], [[3dvl]], [[3jzm]], [[3k09]], [[3k0a]], [[3k0c]], [[3k0e]], [[3k0f]], [[3s1a]], [[4dug]], [[4ijm]] – SeKaiC (mutant)  <br />
+<references/>
 [[Category:Topic Page]]