CD44: Difference between revisions
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< | <StructureSection load='2jcq' size='350' side='right' scene='' caption='Mouse CD44 hyaluronan-binding domain complex with glucuronic acid, NAG and ethylene glycerol (PDB code [[2jcq]])'> | ||
== Function == | == Function == | ||
'''CD44''' is a glycoprotein involved in cell-cell interactions. CD44 is a receptor of hyaluronic acid (HA). CD44 undergoes post-translational modification. Its sialofucosylation changes it to a form which directs migration of stem cells to bone marrow.<ref>PMID: | '''CD44''' is a glycoprotein involved in cell-cell interactions. CD44 is a receptor of hyaluronic acid (HA). CD44 undergoes post-translational modification. Its sialofucosylation changes it to a form which directs migration of stem cells to bone marrow.<ref>PMID:25195884</ref> | ||
*<scene name='52/523368/Cv/ | *<scene name='52/523368/Cv/4'>Binding site of CD44 hyaluronan-binding domain</scene> ([[2jcq]]).<ref>PMID:17293874</ref> | ||
== Relevance == | == Relevance == | ||
CD44 is a potential drug target for treatment of malignant neoplasms. Anti-CD44 antibody treatment lowers hyperglycemia and chronic inflammatory diseases. | CD44 is a potential drug target for treatment of malignant neoplasms. Anti-CD44 antibody treatment lowers hyperglycemia and chronic inflammatory diseases. | ||
</StructureSection> | |||
==3D structures of CD44== | ==3D structures of CD44== | ||
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | ||
[[1uuh]], [[4pz4]] – hCD44 hyaluronan-binding domain – human<br /> | [[1uuh]], [[4pz4]] – hCD44 hyaluronan-binding domain 18-171 – human<br /> | ||
[[1poz]], [[2i83]] - hCD44 hyaluronan-binding domain – NMR<br /> | [[1poz]], [[2i83]] - hCD44 hyaluronan-binding domain – NMR<br /> | ||
[[2jcp]] - mCD44 hyaluronan-binding domain – mouse<br /> | [[4pz3]] - hCD44 hyaluronan-binding domain + tetrapeptide<br /`> | ||
[[2jcp]] - mCD44 hyaluronan-binding domain 23-172 – mouse<br /> | |||
[[2jcq]], [[2jcr]] - mCD44 hyaluronan-binding domain + 8-mer HA<br /> | [[2jcq]], [[2jcr]] - mCD44 hyaluronan-binding domain + 8-mer HA<br /> | ||
[[4mrd]], [[4mre]], [[4mrf]], [[4mrg]], [[4mrh]], [[4np2]], [[4np3]] - mCD44 hyaluronan-binding domain + inhibitor<br /> | [[4mrd]], [[4mre]], [[4mrf]], [[4mrg]], [[4mrh]], [[4np2]], , [[4np3]], [[5bzc]], [[5bzk]], [[5sbk]], [[5sbl]], [[5sbm]], [[5sbn]], [[5sbo]], [[5sbp]], [[5sbq]], [[5sbr]], [[5sbs]], [[5sbt]], [[5sbu]], [[5sbv]], [[5sbw]], [[5sbx]], [[5sby]], [[5sbz]], [[5sc0]], [[5sc1]], [[5sc2]], [[5sc3]], [[5sc4]], [[5sc5]], [[5sc6]], [[5sc7]] - mCD44 hyaluronan-binding domain + inhibitor<br /> | ||
[[5bze]], [[5bzf]], [[5bzg]], [[5bzh]], [[5bzi]], [[5bzj]], [[5bzl]], [[5bzm]], [[5bzn]], [[5bzo]], [[5bzp]], [[5bzq]], [[5bzr]], [[5bzs]], [[5bzt]] - mCD44 hyaluronan-binding domain (mutant) + inhibitor<br /> | |||
[[4np3]] - mCD44 hyaluronan-binding domain + tetrapeptide<br /> | [[4np3]] - mCD44 hyaluronan-binding domain + tetrapeptide<br /> | ||
== References == | |||
<references/> | |||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||