Insulin-like growth factor receptor: Difference between revisions

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Michal Harel, Alexander Berchansky

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 <StructureSection load='3i81' size='350' side='right' scene='' caption='Human insulin-like growth factor 1 receptor complex with inhibitor (PDB code [[3i81]])'>
-'''Insulin-like growth factor receptors''' (IGFR) are transmembrane receptors which are stimulated by insulin-like growth factors (IGF).  IGFR contains 2 extracellular α chains and 2 transmembranal β chains.  Upon binding of IGF, a tyrosine in the β chain becomes autophosphorylated and triggers a cascade of intracellular signaling. The insulin-like growth factor 1 (IGF-1) receptor belongs to the large class of [[Receptor tyrosine kinases|tyrosine kinase receptors]]. See also [[IGF1]], [[Growth factors]]and [[Kinase-linked, enzyme-linked and related receptors]].
+'''Insulin-like growth factor receptors''' (IGFR) are transmembrane receptors which are stimulated by insulin-like growth factors (IGF).  IGFR contains 2 extracellular α chains and 2 transmembranal β chains.  Upon binding of IGF, a tyrosine in the β chain becomes autophosphorylated and triggers a cascade of intracellular signaling. The insulin-like growth factor 1 (IGF-1) receptor belongs to the large class of [[Receptor tyrosine kinases|tyrosine kinase receptors]]. See also [[IGF1]], [[Growth factors]] and [[Kinase-linked, enzyme-linked and related receptors]].
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+*'''Insulin-like growth factor receptor 1''' is the mediator of the anabolic and mitogenic activity of growth hormone<ref>PMID: 11577173</ref><br />
+*'''Insulin-like growth factor receptor 2''' is a protein hormone regulating cell proliferation, growth, migration, differentiation and survival<ref>PMID: 23257688</ref><br />.
 ===  Memory-Enhancement by Traditional Chinese Medicine? <ref>doi 10.1080/07391102.2012.741052</ref>===