4bap: Difference between revisions

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-[[Image:4bap.png|left|200px]]
-{{STRUCTURE_4bap|  PDB=4bap  |  SCENE=  }}
+==Hen egg-white lysozyme structure in complex with the europium tris- hydroxyethylcholinetriazoledipicolinate complex at 1.21 A resolution.==
+<StructureSection load='4bap' size='340' side='right'caption='[[4bap]], [[Resolution|resolution]] 1.21&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[4bap]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BAP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4BAP FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.207&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=DCJ:N-((1-(2,6-DICARBOXYPYRIDIN-4-YL)-1H-1,2,3-TRIAZOL-4-YL)METHYL)-2-HYDROXY-N,N-DIMETHYLETHANAMINIUM'>DCJ</scene>, <scene name='pdbligand=EU3:EUROPIUM+(III)+ION'>EU3</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4bap FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bap OCA], [https://pdbe.org/4bap PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4bap RCSB], [https://www.ebi.ac.uk/pdbsum/4bap PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4bap ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/LYSC_CHICK LYSC_CHICK] Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents. Has bacteriolytic activity against M.luteus.<ref>PMID:22044478</ref>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+New trisdipicolinic acid-lanthanide complexes are reported as phasing agents for X-ray crystallography of proteins. It is demonstrated that CuAAC modifications allow protein co-crystallization with low concentration of lanthanide complexes leading to an accurate structure determination.
-===Hen egg-white lysozyme structure in complex with the europium tris- hydroxyethylcholinetriazoledipicolinate complex at 1.21 A resolution.===
+Clicked europium dipicolinate complexes for protein X-ray structure determination.,Talon R, Nauton L, Canet JL, Kahn R, Girard E, Gautier A Chem Commun (Camb). 2012 Nov 12;48(97):11886-8. doi: 10.1039/c2cc36982f. PMID:23123834<ref>PMID:23123834</ref>
-{{ABSTRACT_PUBMED_23123834}}
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+</div>
+<div class="pdbe-citations 4bap" style="background-color:#fffaf0;"></div>
-==About this Structure==
+==See Also==
-[[4bap]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BAP OCA].
+*[[Lysozyme 3D structures|Lysozyme 3D structures]]
+== References ==
-==Reference==
+<references/>
-<ref group="xtra">PMID:018350532</ref><ref group="xtra">PMID:020606256</ref><references group="xtra"/>
+__TOC__
+</StructureSection>
 [[Category: Gallus gallus]]
-[[Category: Lysozyme]]
+[[Category: Large Structures]]
-[[Category: Gautier, A.]]
+[[Category: Gautier A]]
-[[Category: Girard, E.]]
+[[Category: Girard E]]
-[[Category: Kahn, R.]]
+[[Category: Kahn R]]
-[[Category: Nauton, L.]]
+[[Category: Nauton L]]
-[[Category: Talon, R.]]
+[[Category: Talon R]]
-[[Category: Anomalous scattering]]
-[[Category: Click-chemistry]]
-[[Category: De novo phasing]]
-[[Category: Dipicolinate]]
-[[Category: Experimental phasing]]
-[[Category: Hydrolase]]
-[[Category: Lanthanide complex]]