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[[Image:4bab.jpg|left|200px]]


{{STRUCTURE_4bab| PDB=4bab | SCENE= }}  
==Redesign of a Phenylalanine Aminomutase into a beta-Phenylalanine Ammonia Lyase==
<StructureSection load='4bab' size='340' side='right'caption='[[4bab]], [[Resolution|resolution]] 2.56&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4bab]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Taxus_chinensis Taxus chinensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BAB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4BAB FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.56&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MDO:{2-[(1S)-1-AMINOETHYL]-4-METHYLIDENE-5-OXO-4,5-DIHYDRO-1H-IMIDAZOL-1-YL}ACETIC+ACID'>MDO</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4bab FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bab OCA], [https://pdbe.org/4bab PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4bab RCSB], [https://www.ebi.ac.uk/pdbsum/4bab PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4bab ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/PAM_TAXCH PAM_TAXCH] Phenylalanine aminomutase that catalyzes the rearrangement of L-phenylalanine to R-beta-phenylalanine. Catalyzes the first committed step in the biosynthesis of the side chain of the alkaloid taxol (paclitaxel), a widely-used compound with antitumor activity. Has also low phenylalanine ammonia-lyase activity and can catalyze the amination of trans-cinnamate.<ref>PMID:15878763</ref> <ref>PMID:22113970</ref> <ref>PMID:24786474</ref>


===Redesign of a Phenylalanine Aminomutase into a beta-Phenylalanine Ammonia Lyase===
==See Also==
 
*[[Aminomutase 3D structures|Aminomutase 3D structures]]
 
== References ==
==About this Structure==
<references/>
[[4bab]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Taxus_wallichiana_var._chinensis Taxus wallichiana var. chinensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BAB OCA].
__TOC__
[[Category: Taxus wallichiana var. chinensis]]
</StructureSection>
[[Category: Bartsch, S.]]
[[Category: Large Structures]]
[[Category: Dijkstra, B W.]]
[[Category: Taxus chinensis]]
[[Category: Heberling, M M.]]
[[Category: Bartsch S]]
[[Category: Jansen, M.]]
[[Category: Dijkstra BW]]
[[Category: Janssen, D B.]]
[[Category: Heberling MM]]
[[Category: Wu, B.]]
[[Category: Jansen M]]
[[Category: Wybenga, G G.]]
[[Category: Janssen DB]]
[[Category: Lyase]]
[[Category: Wu B]]
[[Category: Mio]]
[[Category: Wybenga GG]]

Latest revision as of 09:22, 17 October 2024

Redesign of a Phenylalanine Aminomutase into a beta-Phenylalanine Ammonia LyaseRedesign of a Phenylalanine Aminomutase into a beta-Phenylalanine Ammonia Lyase

Structural highlights

4bab is a 4 chain structure with sequence from Taxus chinensis. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.56Å
Ligands:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

PAM_TAXCH Phenylalanine aminomutase that catalyzes the rearrangement of L-phenylalanine to R-beta-phenylalanine. Catalyzes the first committed step in the biosynthesis of the side chain of the alkaloid taxol (paclitaxel), a widely-used compound with antitumor activity. Has also low phenylalanine ammonia-lyase activity and can catalyze the amination of trans-cinnamate.[1] [2] [3]

See Also

References

  1. ↑ Steele CL, Chen Y, Dougherty BA, Li W, Hofstead S, Lam KS, Xing Z, Chiang SJ. Purification, cloning, and functional expression of phenylalanine aminomutase: the first committed step in Taxol side-chain biosynthesis. Arch Biochem Biophys. 2005 Jun 1;438(1):1-10. PMID:15878763 doi:http://dx.doi.org/10.1016/j.abb.2005.04.012
  2. ↑ Wu B, Szymanski W, Wybenga GG, Heberling MM, Bartsch S, de Wildeman S, Poelarends GJ, Feringa BL, Dijkstra BW, Janssen DB. Mechanism-inspired engineering of phenylalanine aminomutase for enhanced beta-regioselective asymmetric amination of cinnamates. Angew Chem Int Ed Engl. 2012 Jan 9;51(2):482-6. doi: 10.1002/anie.201106372. Epub, 2011 Nov 23. PMID:22113970 doi:http://dx.doi.org/10.1002/anie.201106372
  3. ↑ Wybenga GG, Szymanski W, Wu B, Feringa BL, Janssen DB, Dijkstra BW. Structural Investigations into the Stereochemistry and Activity of a Phenylalanine-2,3-aminomutase from Taxus chinensis. Biochemistry. 2014 May 12. PMID:24786474 doi:http://dx.doi.org/10.1021/bi500187a

4bab, resolution 2.56Å

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