4bab: Difference between revisions

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OCA

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-'''Unreleased structure'''
-The entry 4bab is ON HOLD
+==Redesign of a Phenylalanine Aminomutase into a beta-Phenylalanine Ammonia Lyase==
+<StructureSection load='4bab' size='340' side='right'caption='[[4bab]], [[Resolution|resolution]] 2.56&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[4bab]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Taxus_chinensis Taxus chinensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BAB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4BAB FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.56&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MDO:{2-[(1S)-1-AMINOETHYL]-4-METHYLIDENE-5-OXO-4,5-DIHYDRO-1H-IMIDAZOL-1-YL}ACETIC+ACID'>MDO</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4bab FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bab OCA], [https://pdbe.org/4bab PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4bab RCSB], [https://www.ebi.ac.uk/pdbsum/4bab PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4bab ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/PAM_TAXCH PAM_TAXCH] Phenylalanine aminomutase that catalyzes the rearrangement of L-phenylalanine to R-beta-phenylalanine. Catalyzes the first committed step in the biosynthesis of the side chain of the alkaloid taxol (paclitaxel), a widely-used compound with antitumor activity. Has also low phenylalanine ammonia-lyase activity and can catalyze the amination of trans-cinnamate.<ref>PMID:15878763</ref> <ref>PMID:22113970</ref> <ref>PMID:24786474</ref>
-Authors: Bartsch, S., Wybenga, G.G., Jansen, M., Heberling, M.M., Wu, B., Dijkstra, B.W., Janssen, D.B.
+==See Also==
+*[[Aminomutase 3D structures|Aminomutase 3D structures]]
-Description: Redesign of a Phenylalanine Aminomutase into a beta-Phenylalanine Ammonia Lyase
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Large Structures]]
+[[Category: Taxus chinensis]]
+[[Category: Bartsch S]]
+[[Category: Dijkstra BW]]
+[[Category: Heberling MM]]
+[[Category: Jansen M]]
+[[Category: Janssen DB]]
+[[Category: Wu B]]
+[[Category: Wybenga GG]]