4b7r: Difference between revisions
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==H1N1 2009 Pandemic Influenza Virus: Resistance of the I223R Neuraminidase Mutant Explained by Kinetic and Structural Analysis== | ==H1N1 2009 Pandemic Influenza Virus: Resistance of the I223R Neuraminidase Mutant Explained by Kinetic and Structural Analysis== | ||
<StructureSection load='4b7r' size='340' side='right' caption='[[4b7r]], [[Resolution|resolution]] 1.90Å' scene=''> | <StructureSection load='4b7r' size='340' side='right'caption='[[4b7r]], [[Resolution|resolution]] 1.90Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4b7r]] is a 4 chain structure with sequence from [ | <table><tr><td colspan='2'>[[4b7r]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Influenza_A_virus_(A/California/07/2009(H1N1)) Influenza A virus (A/California/07/2009(H1N1))]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4B7R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4B7R FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=G39:(3R,4R,5S)-4-(ACETYLAMINO)-5-AMINO-3-(PENTAN-3-YLOXY)CYCLOHEX-1-ENE-1-CARBOXYLIC+ACID'>G39</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene> | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9Å</td></tr> | ||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=G39:(3R,4R,5S)-4-(ACETYLAMINO)-5-AMINO-3-(PENTAN-3-YLOXY)CYCLOHEX-1-ENE-1-CARBOXYLIC+ACID'>G39</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4b7r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4b7r OCA], [https://pdbe.org/4b7r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4b7r RCSB], [https://www.ebi.ac.uk/pdbsum/4b7r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4b7r ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[ | [https://www.uniprot.org/uniprot/C7FH46_9INFA C7FH46_9INFA] Catalyzes the removal of terminal sialic acid residues from viral and cellular glycoconjugates.[RuleBase:RU361252] | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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==See Also== | ==See Also== | ||
*[[Neuraminidase|Neuraminidase]] | *[[Neuraminidase 3D structures|Neuraminidase 3D structures]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Boucher | [[Category: Large Structures]] | ||
[[Category: Collins | [[Category: Boucher CAB]] | ||
[[Category: Gamblin | [[Category: Collins PJ]] | ||
[[Category: Haire | [[Category: Gamblin SJ]] | ||
[[Category: Hay | [[Category: Haire LF]] | ||
[[Category: Liu | [[Category: Hay AJ]] | ||
[[Category: Martin | [[Category: Liu J]] | ||
[[Category: Osterhaus | [[Category: Martin SR]] | ||
[[Category: Schutten | [[Category: Osterhaus ADME]] | ||
[[Category: Skehel | [[Category: Schutten M]] | ||
[[Category: Vachieri | [[Category: Skehel JJ]] | ||
[[Category: Vachieri SG]] | |||
[[Category: Walker | [[Category: Walker PA]] | ||
[[Category: Xiong | [[Category: Xiong X]] | ||
[[Category: | [[Category: Van der Vries E]] | ||