4b6v: Difference between revisions
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==The third member of the eIF4E family represses gene expression via a novel mode of recognition of the methyl-7 guanosine cap moiety== | ==The third member of the eIF4E family represses gene expression via a novel mode of recognition of the methyl-7 guanosine cap moiety== | ||
<StructureSection load='4b6v' size='340' side='right' caption='[[4b6v | <StructureSection load='4b6v' size='340' side='right'caption='[[4b6v]]' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4b6v]] is a 1 chain structure with sequence from [ | <table><tr><td colspan='2'>[[4b6v]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4B6V OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4B6V FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4b6v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4b6v OCA], [https://pdbe.org/4b6v PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4b6v RCSB], [https://www.ebi.ac.uk/pdbsum/4b6v PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4b6v ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[ | [https://www.uniprot.org/uniprot/IF4E3_MOUSE IF4E3_MOUSE] Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis. May act as an inhibitor of EIF4E1 activity.<ref>PMID:15153109</ref> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
<div class="pdbe-citations 4b6v" style="background-color:#fffaf0;"></div> | |||
==See Also== | |||
*[[Eukaryotic initiation factor 3D structures|Eukaryotic initiation factor 3D structures]] | |||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: Baguet | [[Category: Mus musculus]] | ||
[[Category: Borden | [[Category: Baguet A]] | ||
[[Category: Culjkovic-Kraljcic | [[Category: Borden KLB]] | ||
[[Category: Kornblatt | [[Category: Culjkovic-Kraljcic B]] | ||
[[Category: Osborne | [[Category: Kornblatt JA]] | ||
[[Category: Volpon | [[Category: Osborne MJ]] | ||
[[Category: Volpon L]] | |||