Vasodilator-stimulated phosphoprotein: Difference between revisions
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<StructureSection load='' size='350' side='right' caption='Human VASP (dark olive) complex with α-actin (cyan), profilin-1 (green), ATP (stick model) and Ca+2 ion (green), [[2pbd]]' scene='50/508423/Cv/7' > | |||
<StructureSection load=' | == Function == | ||
'''Vasodilator-stimulated phosphoprotein''' (VASP) belongs to the Ena-VASP family. It binds proteins with E/DFPPPPXD/E motif and targets them to focal adhesion cell membranes. VASP is associated with filament formation and promotes elongation. | '''Vasodilator-stimulated phosphoprotein''' (VASP) belongs to the Ena-VASP family. It binds proteins with E/DFPPPPXD/E motif and targets them to focal adhesion cell membranes. VASP is an actin- and profilin-binding protein<ref>PMID:16197368</ref>. VASP is associated with filament formation and promotes elongation. | ||
VASP protects the actin barb edge against capping and increases the rate of actin polymerization in the presence of capping protein. VASP is a homotetramer. | VASP protects the actin barb edge against capping and increases the rate of actin polymerization in the presence of capping protein. VASP is a homotetramer. | ||
For more details see [[Group:MUZIC:Mena_VASP]]. | For more details see [[Group:MUZIC:Mena_VASP]]. | ||
== Relevance == | |||
VASP restricts the spread of Shigella which causes diarrhoreal disease<ref>PMID:26358985</ref>. | |||
==Structural highlights == | |||
<scene name='50/508423/Cv/9'>Human VASP complex with α-actin, profilin-1, ATP (stick model) and Ca+2 ion</scene> ([[2pbd]]). VASP binds actin with a <scene name='50/508423/Cv/10'>poly-Pro site</scene><ref>PMID:17914456</ref>. | |||
</StructureSection> | </StructureSection> | ||
==3D structure of vasodilator-stimulated phosphoprotein== | ==3D structure of vasodilator-stimulated phosphoprotein== | ||
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | ||
[[1egx]] – hVASP EVH1 domain – human – NMR<BR /> | [[1egx]] – hVASP EVH1 domain 1-115 – human – NMR<BR /> | ||
[[ | [[1use]] - hVASP tetramerization domain 335-379<br /> | ||
[[2pav]], [[ | [[1usd]] - hVASP tetramerization domain (mutant)<br /> | ||
[[2pav]], [[3chw]] – hVASP 199-214 + actin + profilin-1<br /> | |||
[[2pbd]] – hVASP poly Pro domain 203-245 + actin + profilin-1<br /> | |||
[[2v8c]] – hVASP 165-184 + profilin-2<br /> | |||
[[8gat]], [[8gau]] – hVASP tetramerization domain/neuroaminidase + antibody – Cryo EM<BR /> | |||
==References== | ==References== | ||
<references /> | <references /> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||