5n2o: Difference between revisions

<StructureSection load='5n2o' size='340' side='right'caption='[[5n2o]]' scene=''>

<table><tr><td colspan='2'>[[5n2o]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5N2O OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5N2O FirstGlance]. <br>

</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5n2o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5n2o OCA], [https://pdbe.org/5n2o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5n2o RCSB], [https://www.ebi.ac.uk/pdbsum/5n2o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5n2o ProSAT]</span></td></tr>

[https://www.uniprot.org/uniprot/P63_MOUSE P63_MOUSE] Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. Involved in Notch signaling by probably inducing JAG1 and JAG2. Activates transcription of the p21 promoter (By similarity). Activates RIPK4 transcription. Plays a role in the regulation of epithelial morphogenesis. The ratio of DeltaN-type and TA*-type isoforms may govern the maintenance of epithelial stem cell compartments and regulate the initiation of epithelial stratification from the undifferentiated embryonal ectoderm. Required for limb formation from the apical ectodermal ridge.<ref>PMID:10227293</ref> <ref>PMID:10227294</ref> <ref>PMID:11932750</ref> <ref>PMID:14729569</ref> <ref>PMID:22197488</ref>  

[[Category: Mus musculus]]

[[Category: Doetsch V]]

[[Category: Guentert P]]

[[Category: Osterburg C]]

[[Category: Rinnenthal J]]

[[Category: Wuerz JM]]