3vv7: Difference between revisions

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 ==Crystal Structure of beta secetase in complex with 2-amino-6-((1S,2R)-2-(3'-methoxybiphenyl-3-yl)cyclopropyl)-3-methylpyrimidin-4(3H)-one==
-<StructureSection load='3vv7' size='340' side='right' caption='[[3vv7]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
+<StructureSection load='3vv7' size='340' side='right'caption='[[3vv7]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[3vv7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VV7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3VV7 FirstGlance]. <br>
+<table><tr><td colspan='2'>[[3vv7]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VV7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3VV7 FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=0B1:2-AMINO-6-[(1S,2R)-2-(3-METHOXYBIPHENYL-3-YL)CYCLOPROPYL]-3-METHYLPYRIMIDIN-4(3H)-ONE'>0B1</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
-<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3vv6|3vv6]], [[3vv8|3vv8]]</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0B1:2-AMINO-6-[(1S,2R)-2-(3-METHOXYBIPHENYL-3-YL)CYCLOPROPYL]-3-METHYLPYRIMIDIN-4(3H)-ONE'>0B1</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene></td></tr>
-<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">BACE1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3vv7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3vv7 OCA], [https://pdbe.org/3vv7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3vv7 RCSB], [https://www.ebi.ac.uk/pdbsum/3vv7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3vv7 ProSAT]</span></td></tr>
-<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Memapsin_2 Memapsin 2], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.46 3.4.23.46] </span></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3vv7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3vv7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3vv7 RCSB], [http://www.ebi.ac.uk/pdbsum/3vv7 PDBsum]</span></td></tr>
 </table>
-== Function ==
-[[http://www.uniprot.org/uniprot/BACE1_HUMAN BACE1_HUMAN]] Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.<ref>PMID:10677483</ref> <ref>PMID:20354142</ref>
 <div style="background-color:#fffaf0;">
 == Publication Abstract from PubMed ==
@@ Line 19: / Line 16: @@
 From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 </div>
+<div class="pdbe-citations 3vv7" style="background-color:#fffaf0;"></div>
 ==See Also==
-*[[Beta secretase|Beta secretase]]
+*[[Beta secretase 3D structures|Beta secretase 3D structures]]
 == References ==
 <references/>
@@ Line 27: / Line 25: @@
 </StructureSection>
 [[Category: Homo sapiens]]
-[[Category: Memapsin 2]]
+[[Category: Large Structures]]
-[[Category: Arisawa, M]]
+[[Category: Arisawa M]]
-[[Category: Hattori, K]]
+[[Category: Hattori K]]
-[[Category: Higashino, K]]
+[[Category: Higashino K]]
-[[Category: Hosono, M]]
+[[Category: Hosono M]]
-[[Category: Muto, C]]
+[[Category: Muto C]]
-[[Category: Nakano, T]]
+[[Category: Nakano T]]
-[[Category: Sakagami, M]]
+[[Category: Sakagami M]]
-[[Category: Shuto, S]]
+[[Category: Shuto S]]
-[[Category: Takemoto, H]]
+[[Category: Takemoto H]]
-[[Category: Tanaka, Y]]
+[[Category: Tanaka Y]]
-[[Category: Togame, H]]
+[[Category: Togame H]]
-[[Category: Yamakawa, H]]
+[[Category: Yamakawa H]]
-[[Category: Yamamoto, T]]
+[[Category: Yamamoto T]]
-[[Category: Yonezawa, S]]
+[[Category: Yonezawa S]]
-[[Category: Aspartyl protease]]
-[[Category: Base]]
-[[Category: Beta-secretase]]
-[[Category: Hydrolase-hydrolase inhibitor complex]]