Estrogen-related receptor: Difference between revisions

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<StructureSection load='2gpv' size='350' side='right' scene='' caption='Human estrogen-related receptor γ ligand-binding domain (cyan, grey, green, yellow, pink, purple) complex with nuclear receptor corepressor 2 peptide (dark red, orange) and 4-hydroxytamoxifen (PDB code [[2gpv]]) '>
<StructureSection load='2gpv' size='350' side='right' scene='50/501401/Cv/1' caption='Human estrogen-related receptor γ ligand-binding domain (cyan, grey, green, yellow, pink, purple) complex with nuclear receptor corepressor 2 peptide (dark red, orange) and 4-hydroxytamoxifen (PDB code [[2gpv]]) '>
== Function ==
== Function ==


'''Estrogen-related receptor''' (ERR) binds to estrogen response elements on DNA and modulates transcription in response to [[Hormone|hormone]]. There are 3 classes of ERR : ERRα, ERRβ and ERRγ.
'''Estrogen-related receptor''' (ERR) binds to estrogen response elements on DNA and modulates transcription in response to [[Hormone|hormone]]. It is a [[Nuclear receptors|nuclear receptor]]. There are 3 classes of ERR : ERRα, ERRβ and ERRγ.
*'''ERR alpha''' regulates cellular metabolism and function<ref>PMID:32121253</ref>.
*'''ERR beta''' is expressed in the inner ear and controls the development of its endolymph-producing cells<ref>PMID:17765677</ref>.
*'''ERR gamma''' regulates the perinatal switch to oxidative metabolism in the myocardium<ref>PMID:20418374</ref>.
 
See also [[Intracellular receptors]]


== Relevance ==
== Relevance ==


ERR plays a role in energy homeostasis and cancer<ref>PMID:16515477</ref>.  ERRα and ERRγ are overexpressed in breast cancer and can serve as prognostic markers or therapeutic targets.
ERR plays a role in energy homeostasis and cancer<ref>PMID:16515477</ref>.  ERRα and ERRγ are overexpressed in breast cancer and can serve as prognostic markers or therapeutic targets.
</StructureSection>


==3D structures of estrogen-related receptor==
== Structural insights ==


Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
<scene name='50/501401/Cv/4'>Binding of nuclear receptor corepressor 2 peptide and 4-hydroxytamoxifen</scene> to human estrogen-related receptor γ. The chemotherapeutic drugs bisphenol and <scene name='50/501401/Cv/5'>tamoxifen</scene> are nestled between 4 alpha helices in the ERR active site <ref>PMID:16990259</ref>. 
{{#tree:id=OrganizedByTopic|openlevels=0|


*ERR
==3D structures of estrogen-related receptor==
[[Estrogen-related receptor 3D structures]]


**[[1xb7]], [[3d24]] – hERR ligand-binding domain + peroxisome proliferator activated receptor coactivator 1 peptide – human<br />[[2pjl]] - hERR ligand-binding domain (mutant) + inverse agonist<br />
</StructureSection>
**[[3k6p]] - hERR ligand-binding domain + ligand
 
*ERRβ
 
**[[1lo1]] – hERR DNA-binding domain + DNA - NMR
 
*ERRγ


**[[2gp7]], [[2zbs]] - hERR ligand-binding domain<br />
**[[1kv6]], [[1tfc]] – hERR ligand-binding domain + steroid receptor coactivator 1 2nd NR-Box <br />
**[[2gpo]], [[2gpp]] - hERR ligand-binding domain + nuclear receptor-interacting protein 1 peptide<br />
**[[2ewp]] - hERR ligand-binding domain + tamoxifen analog<br />
**[[2gpu]], [[2p7z]] - hERR ligand-binding domain + 4-hydroxytamoxifen<br />
**[[2e2r]], [[2p7g]] - hERR ligand-binding domain + bisphenol A<br />
**[[2zkc]] - hERR ligand-binding domain + bisphenol Z<br />
**[[2zas]] - hERR ligand-binding domain + bisphenol A derivative<br />
**[[2p7a]] - hERR ligand-binding domain + methyl phenol<br />
**[[2gpv]] - hERR ligand-binding domain + nuclear receptor corepressor 2 peptide + 4-hydroxytamoxifen<br />
**[[1s9p]], [[1s9q]] - mERR ligand-binding domain + diethylstilbesterol – mouse<br />
**[[1vjb]] - mERR ligand-binding domain + 4-hydroxytamoxifen<br />
}}
== References ==
== References ==
<references/>
<references/>

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Wayne Decatur, Alexander Berchansky
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