Estrogen-related receptor: Difference between revisions

← Older edit

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Wayne Decatur, Alexander Berchansky

@@ Line 1: / Line 1: @@
-{{STRUCTURE_2pgu|  PDB=2pgu  | SIZE=400| SCENE= |right|CAPTION=Human estrogen-related receptor γ complex with 4-hydroxytamoxifen, [[2pgu]] }}
+<StructureSection load='2gpv' size='350' side='right' scene='50/501401/Cv/1' caption='Human estrogen-related receptor γ ligand-binding domain (cyan, grey, green, yellow, pink, purple) complex with nuclear receptor corepressor 2 peptide (dark red, orange) and 4-hydroxytamoxifen (PDB code [[2gpv]]) '>
+== Function ==
-<!--
+'''Estrogen-related receptor''' (ERR) binds to estrogen response elements on DNA and modulates transcription in response to [[Hormone|hormone]]. It is a [[Nuclear receptors|nuclear receptor]]. There are 3 classes of ERR : ERRα, ERRβ and ERRγ.
-Please use the "3D" button above this box to insert a Jmol applet (molecule) on this page.
+*'''ERR alpha''' regulates cellular metabolism and function<ref>PMID:32121253</ref>.
-Or use the four-green-boxes-button to insert scrollable text adjacent
+*'''ERR beta''' is expressed in the inner ear and controls the development of its endolymph-producing cells<ref>PMID:17765677</ref>.
-to a Jmol applet. Check out the other buttons as well!
+*'''ERR gamma''' regulates the perinatal switch to oxidative metabolism in the myocardium<ref>PMID:20418374</ref>.
--->
-'''Estrogen-related receptor''' (ERR) binds to estrogen response elements on DNA and modulates transcription.  ERR plays a role in energy homeostasis and cancer.  There are 3 classes of ERR : ERRα, ERRβ and ERRγ.
-==3D structures of estrogen-related receptor==
+See also [[Intracellular receptors]]
+== Relevance ==
+ERR plays a role in energy homeostasis and cancer<ref>PMID:16515477</ref>.  ERRα and ERRγ are overexpressed in breast cancer and can serve as prognostic markers or therapeutic targets.
+== Structural insights ==
-===ERRα===
+<scene name='50/501401/Cv/4'>Binding of nuclear receptor corepressor 2 peptide and 4-hydroxytamoxifen</scene> to human estrogen-related receptor γ. The chemotherapeutic drugs bisphenol and <scene name='50/501401/Cv/5'>tamoxifen</scene> are nestled between 4 alpha helices in the ERR active site <ref>PMID:16990259</ref>.
-[[1xb7]], [[3d24 – hERR ligand-binding domain + peroxisome proliferator activated receptor coactivator 1 peptide – human<br />[[2pjl]] - hERR ligand-binding domain (mutant) + inverse agonist<br />
+==3D structures of estrogen-related receptor==
-[[3k6p]] - hERR ligand-binding domain + ligand
+[[Estrogen-related receptor 3D structures]]
-===ERRβ===
+</StructureSection>
-[[1lo1]] – hERR DNA-binding domain + DNA
+== References ==
+<references/>
-===ERRγ===
-[[2gp7]], [[2zbs]] - hERR ligand-binding domain<br />
+[[Category:Topic Page]]
-[[1kv6]], [[1tfc]] – hERR ligand-binding domain + steroid receptor coactivator 1 2nd NR-Box <br />
-[[2gpo]], [[2gpp]] - hERR ligand-binding domain + nuclear receptor-interacting protein 1 peptide<br />
-[[2ewp]] - hERR ligand-binding domain + tamoxifen analog<br />
-[[2gpu]], [[2p7z]] - hERR ligand-binding domain + 4-hydroxytamoxifen<br />
-[[2e2r]], [[2p7g]] - hERR ligand-binding domain + bisphenol A<br />
-[[2zkc]] - hERR ligand-binding domain + bisphenol Z<br />
-[[2zas]] - hERR ligand-binding domain + bisphenol A derivative<br />
-[[2p7a]] - hERR ligand-binding domain + methyl phenol<br />
-[[2gpv]] - hERR ligand-binding domain + nuclear receptor corepressor 2 peptide + 4-hydroxytamoxifen<br />
-[[1s9p]] - mERR ligand-binding domain + diethylstilbesterol – mouse<br />
-[[1vjb]] - mERR ligand-binding domain + 4-hydroxytamoxifen<br />