Endonuclease: Difference between revisions

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Michal Harel, Alexander Berchansky, Joel L. Sussman

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 *'''ENN-VIII''' removes radiolysis thymine products from phage DNA and cleaves the DNA at AP sites<ref>PMID:9405426</ref>.
 *'''Structure-specific ENN''' specific for DNA secondary structure rather than for its sequence<ref>PMID:28327556</ref>.
-Some ENNs are encoded within introns thus facilitating their mobility.  These ENNs or inteins are designated I-ENN<ref>PMID:12483517</ref>.<br />
+*'''Intron-encoded ENN''' or '''homing ENN''' are encoded by genes with mobile, self-splicing introns. They promote the movement of DNA sequences from one chromosome location to another<ref>PMID:9665136</ref>. <br />
 The '''Cas ENN''' proteins are part of '''CRISPR/Cas''' prokaryotic immune system which confers protection from foreign genetic elements like viruses.  The '''CRISPR''' ('''C'''lustered '''R'''egularly '''I'''nterspersed '''S'''hort '''P'''alindromic '''R'''epeats) are DNA loci which are found in ca. 40% of the bacteria.  The CRISPR/Cas system is being used lately as gene editing tool<ref>PMID:20056882</ref>.  For more details see<br />
 *[[CRISPR-Cas]]
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 *CRISPR type V (Cpf1, C2c1, C2c3) - see [[CRISPR type V]]
 *CRISPR type VI (Cas13a (previously known as C2c2), Cas13b, Cas13c, Cas13d) - see [[CRISPR type VI]]
-'''Intron-encoded ENN''' or '''homing ENN''' are encoded by genes with mobile, self-splicing introns. They promote the movement of DNA sequences from one chromosome location to another<ref>PMID:9665136</ref>. <br />
 See also<br />
 * [[Apurinic-Apyrimidinic Endonuclease-1]]<br />