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{{STRUCTURE_1rva|  PDB=1rva  | SIZE=400| SCENE= |right|CAPTION=E. coli EcoRV endonuclease dimer complex with DNA, [[1rva]] }}
<StructureSection load='' size='350' side='right' scene='49/496318/Cv/1' caption='E. coli EcoRV endonuclease dimer (magenta, green) complex with DNA, (PDB code [[1rva]])'>
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'''Endonuclease''' (ENN) cleaves phosphodiester bond within polynucleotide chain.  ENN cleaves DNA at a restriction site which is usually a 6-nucleotide palindrome.  ENN is restriction site–specific.  Various types of ENN differ by their mechanism of action.  ENN is used in genetic engineering to make recombinant DNA.  ENN requires a restriction site and a cleavage pattern.  ENN-I operates on DNA with separate restriction site and cleavage pattern, while ENN-II operates on overlapping restriction site and cleavage pattern.  Some ENNs are encoded within introns thus facilitating their mobility.  These ENNs or inteins are designated I-ENN.<br />
The '''Cas ENN''' proteins are part of CRISPR/Cas prokaryotic immune system which confers protection from foreign genetic elements like viruses.  The CRISPR (Custered Regularly Interspersed Short Palindromic Repeats) are DNA loci which are found in ca. 40% of the bacteria.  The CRISPR/Cas system is being used lately as gene editing tool.  For more details see [[Cas9]].<br /> See also<br />
* [[Apurinic-Apyrimidinic Endonuclease-1]]<br />
* [[DNA repair protein human endonuclease VIII-like 1 (NEIL1)]] .


==3D structures of endonuclease==
== Function ==


Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
'''Endonuclease''' (ENN) cleaves phosphodiester bond within polynucleotide chain.  ENN cleaves DNA at a restriction site which is usually a 6-nucleotide palindrome.  ENN is restriction site–specific.  Various types of ENN differ by their mechanism of action.  ENN is used in genetic engineering to make recombinant DNA.  ENN requires a restriction site and a cleavage pattern. 
{{#tree:id=OrganizedByTopic|openlevels=0|
*'''ENN-I''' operates on DNA with separate restriction site and cleavage pattern.
*'''ENN-II''' operates on overlapping restriction site and cleavage pattern. 
*'''ENN-III''' is a bifunctional DNA glycosylase that removes oxidized pyrimidines from DNA<ref>PMID:30959406</ref>.
*'''ENN-IV''' cleaves the DNA backbone 5' of AP sites<ref>PMID:10458614</ref>.
*'''ENN-V''' removes deaminated bases from DNA<ref>PMID:23263163</ref>.
*'''ENN-VII''' recognizes mixmatches in DNA recombinational heteroduplexes and performs their incision<ref>PMID:21237725</ref>.
*'''ENN-VIII''' removes radiolysis thymine products from phage DNA and cleaves the DNA at AP sites<ref>PMID:9405426</ref>.
*'''Structure-specific ENN''' specific for DNA secondary structure rather than for its sequence<ref>PMID:28327556</ref>.
*'''Intron-encoded ENN''' or '''homing ENN''' are encoded by genes with mobile, self-splicing introns. They promote the movement of DNA sequences from one chromosome location to another<ref>PMID:9665136</ref>. <br />
The '''Cas ENN''' proteins are part of '''CRISPR/Cas''' prokaryotic immune system which confers protection from foreign genetic elements like viruses.  The '''CRISPR''' ('''C'''lustered '''R'''egularly '''I'''nterspersed '''S'''hort '''P'''alindromic '''R'''epeats) are DNA loci which are found in ca. 40% of the bacteria.  The CRISPR/Cas system is being used lately as gene editing tool<ref>PMID:20056882</ref>.  For more details see<br />
*[[CRISPR-Cas]]
*CRISPR type I-A (Cascade) - see [[CRISPR subtype I-A]]
*CRISPR type I-B (Cascade) - see [[CRISPR subtype I-B]]
*CRISPR type I-C (Cascade) - see [[CRISPR subtype I-C]]
*CRISPR type I-E (Cascade) - see [[CRISPR type I-E (Cascade)|CRISPR subtype I-E]]
*(CRISPR type I-F (Csy1, Csy2, Csy3) - see [[CRISPR subtype I-F]]
*CRISPR type III-A (Csm complex) - see [[CRISPR subtype III-A (Csm complex)]]
*CRISPR type II-A - see [[CRISPR-Cas9]]
*CRISPR type V (Cpf1, C2c1, C2c3) - see [[CRISPR type V]]
*CRISPR type VI (Cas13a (previously known as C2c2), Cas13b, Cas13c, Cas13d) - see [[CRISPR type VI]]
See also<br />
* [[Apurinic-Apyrimidinic Endonuclease-1]]<br />
* For EcoRV ENN see [[Student Projects for UMass Chemistry 423 Spring 2012-3]]<br />
* For NEI ENN see [[DNA repair protein human endonuclease VIII-like 1 (NEIL1)]].


*ENN-I
== Relevance ==


**[[1bix]] - hENN – human<br />
Sickle cell anemia is caused by mutation in the recognition site of MstII ENN.
**[[1cfr]] – ENN – ''Citrobacter freundii''<br />
**[[1af5]] - CrENN – ''Chlamydomonas reinhardtii''<br />
**[[1fzr]], [[1m0d]], [[1m0i]], [[3cae]] – T7ENN - Enterobacteria phage T7<br />
**[[2g7e]], [[2g7f]] – VcENN – ''Vibrio cholera''<br />
**[[2vnd]] - VcENN (mutant) <br />
**[[2pu3]] - VsENN – ''Vibrio salmonicida''


*ENN-II
== Disease ==


**[[1pvi]], [[1pvu]] - ENN – ''Proteus vulgaris''<br />
Mutation in UV-specific ENN causes Xeroderma pigmentosa. Mutations in tRNA-splicing ENN cause pontocerebellar hypoplasia.
**[[2wsh]] - T4ENN (mutant) - Enterobacteria phage T4<br />
**[[3w52]], [[4cwm]], [[4cxo]], [[4cxp]], [[4cxv]] – ENN – ''Arabidopsis thaliana''<br />


*ENN-III
== Structural highlights ==
<scene name='49/496318/Cv/1'>E. coli EcoRV endonuclease dimer with DNA</scene>


**[[2abk]], [[1ako]] - EcENN  – ''Escherichia coli''<br />
<scene name='49/496318/Cv/2'>DNA-protein binding</scene> (PDB code [[1rva]]).
**[[1orn]], [[1orp]], [[1p59]] - GsENN + DNA – ''Geobacillus stearothermophilus''


*ENN-IV
==3D structures of endonuclease==
 
[[Endonuclease 3D structures]]
**[[1qtw]] - EcENN  <br />
**[[2nqh]] - EcENN (mutant) <br />
**[[1qum]] – EcENN + DNA<br />
**[[2nqj]], [[2nq9]], [[4k1g]] - EcENN (mutant) + DNA<br />
**[[1xp3]] - ENN – ''Bacillus anthracis''<br />
**[[3aal]] - GkENN – ''Geobacillus kaustophilus''<br />
**[[3aam]] - TtENN – ''Thermus thermophilus''
 
*ENN-V
 
**[[1eni]], [[1enj]], [[1enk]], [[2end]] - T4ENN  <br />
**[[1vas]] - T4ENN + DNA<br />
**[[2w35]], [[2w36]], [[4b20]] - TmENN + DNA – ''Thermotoga maritima''<br />
**[[3hd0]] - TmENN <br />
**[[3ga2]] - BsENN (mutant) – ''Bacillus subtilis''<br />
**[[3goc]] - ENN – ''Streptomyces avermitilis''<br />
**[[2fcc]] – T4ENN + DNA<br />
**[[4nsp]] – hENN catalytic domain<br />
 
*ENN-VII
 
**[[1en7]], [[1e7d]] - T4ENN <br />
**[[1e7l]] - T4ENN (mutant) <br />
**[[2qnc]], [[2qnf]] - T4ENN (mutant) + DNA
 
*ENN-VIII
 
**[[1q39]], [[1q39]] -  EcENN  <br />
**[[1q3b]], [[1q3c]] -  EcENN  (mutant) <br />
**[[1tdh]] – hENN <br />
**[[1bix]] – hENN + DNA<br />
**[[1k3x]], [[2ea0]], [[1k3w]], [[1k3x]], [[2ea0]], [[2opf]], [[2oq4]] - EcENN + DNA <br />
**[[2opf]], [[2oq4]] - EcENN (mutant) + DNA
 
*AP ENN
 
**[[3ngf]] - ENN - ''Brucella melitensis''<br />
**[[2j63]] – ENN – ''Leishmania major''<br />
 
*Cas ENN
 
**[[1wj9]], [[4ej3]] – TtCas<br />
**[[4n06]] – AfCas1 - ''Archaeoglobus fulgidus'' <br />
**[[3god]] – PaCas1 – ''Pseudomonas aeruginosa''<br />
**[[3nkd]] – EcCas1<br />
**[[4wj0]] – PhCas1 - ''Pyrococcus horikoshii''<br />
**[[4xtk]] – TmCas1<br />
**[[3oq2]] – Cas2 – ''Desulfovibrio vulgaris''<br />
**[[4mak]] – EcCas2<br />
**[[4p6i]], [[4qdl]] – EcCas1 + EcCas2<br />
**[[3s4l]] – MjCas3 – ''Methanocaldococcus jannaschii''<br />
**[[4qqw]] – TfCas3 – ''Thermobifida fusca''<br />
**[[4qqx]] – TfCas3 + ATP <br />
**[[4qqy]] – TfCas3 + ADP <br />
**[[4qqz]] – TfCas3 + AMPPNP <br />
**[[4q2c]] - TteCas3 – ''Thermobaclum terrenum''<br />
**[[4q2d]] - TteCas3 + ATP<br />
**[[3i4h]] – Cas4 - ''Pyrobaculum calidifontis''<br />
**[[4qr0]], [[4qr1]] -  SpCas9 (Csn1) – ''Streptococcus pyogenes''<br />
**[[4ill]], [[4ilm]] – SsCas6 + RNA - ''Sulfolobus solfataricus''<br />
**[[4ilr]], [[3zfv]] – SsCas6 <br />
**[[3i4h]] – PfCas6 - ''Pyrococcus furiosus''<br />
**[[3pkm]] – PfCas6 + RNA<br />
**[[4dzd]] – EcCas6e<br />
**[[2y8w]], [[2y8y]], [[3qrp]], [[3qrq]], [[2qrr]] – TtCas6e (Cse3) + RNA<br />
**[[2xli]], [[2xlj]], [[2xlk]], [[4al7]] – PaCas6f (Csy4) + RNA <br />
**[[4al5]], [[4al6]] - PaCas6f (Csy4) (mutant) + RNA <br />
**[[4cmp]], [[4cmq]] – SpCas9 (Csn1)<br />
**[[4oo8]], [[4un3]], [[4un4]], [[4un5]] - SpCas9 (Csn1) (mutant) + RNA + DNA<br />
**[[4ogc]], [[4oge]] – Cas9 II-C – Actinomyces naeslundii<br />
**[[3ung]], [[3ur3]], [[4doz]], [[4w8y]] – PfCas10 CMR2 subunit <br />
**[[4h4k]] – PfCas10 CMR2+CMR3 subunits <br />
**[[3w2v]] – PfCas10 CMR2+CMR3 subunits + AMP<br />
**[[3w2w]] – PfCas10 CMR2+CMR3 subunits + ATP<br />
**[[4gkf]] – PfCas10 CMR5 subunit<br />
**[[4an8]], [[4f3e]] – TtCasA (Cse1)<br />
**[[4h3t]] - CasA (Cse1) – ''Acidimicrobium ferrooxidans''<br />
**[[4h79]] - TfCasB (Cse2)<br />
**[[3wa8]] - CasB (Cse2) – ''Meiothermus ruber''<br />
**[[4h7a]] - TtCasB (Cse2)<br />
**[[4tvx]] – EcCasA (Cse1) + CasE<br />
**[[4u7u]] – EcCasA (Cse1) + CasB + CasC + CasD + CasE + RNA<br />
**[[4qyz]] – EcCasA (Cse1) + CasB + CasC + CasD + CasE + RNA + DNA<br />
**[[3qhq]] -  Csn2 – ''Streptococcus agalactiae''<br />
**[[3toc]], [[3v7f]] – SpCsn2<br />
**[[3ps0]] – SsCsa2<br />
 
*EcoKI ENN
 
**[[2ar0]] – EcENN (mutant)<br />
 
*Ecoo109I ENN
 
**[[1wtd]] - EcENN<br />
**[[1wte]] – EcENN + DNA<br />
 
*EcoRI ENN
 
**[[1qc9]] - EcENN<br />
**[[1eri]], [[1ckq]], [[1cl8]], [[1qps]] – EcENN + DNA<br />
**[[1qrh]], [[1qri]], [[2oxv]] - EcENN (mutant) + DNA
 
*EcoRII ENN
 
**[[1na6]] – EcENN<br />
**[[3hqf]], [[3hqg]] - EnENN + DNA
 
*EcoRV ENN
 
**[[1rve]], [[1az3]] – EcENN<br />
**[[1az4]] - EcENN (mutant) <br />
**[[2rve]], [[4rve]], [[1rva]], [[1rvb]], [[1rvc]], [[1az0]], [[1bsu]], [[1bua]], [[1bgb]], [[1rv5]], [[1b94]], [[1b95]], [[1eo3]], [[1eo4]], [[1eon]], [[1eoo]], [[1eop]], [[2b0d]], [[2b0e]] - EcENN + DNA<br />
**[[1bss]], [[1b96]], [[1b97]], [[1stx]], [[1suz]], [[1sx5]], [[1sx8]], [[2ge5]] - EcENN (mutant) + DNA
 
*BamHI ENN
 
**[[1bam]] – BaENN – ''Bacillus amyloliquefaciens''<br />
**[[1bhm]], [[3bam]], [[2bam]], [[1esg]] - BaENN + DNA
 
*FokI ENN
 
**[[1fok]] – PoENN + DNA – ''Planomicrobium okeanokoites''<br />
**[[2fok]] – PoENN
 
*PvuII ENN
 
**[[3pvi]] - PvENN (mutant) + DNA – ''Proteus vulgaris''<br />
**[[1k0z]], [[1h56]], [[3ksk]] - PvENN<br />
**[[1ni0]] - PvENN (mutant) <br />
**[[2pvi]], [[1eyu]], [[1f0o]] - PvENN + DNA
 
*tRNA-splicing ENN
 
**[[1a79]], [[1a76]], [[1a77]] - MjENN  – ''Methanocaldococcus jannaschii''<br />
**[[2cv8]] - ENN  – ''Sulfolobus tokodaii''<br />
**[[2gw6]] – hENN subunit sen15 – NMR<br />
**[[2gjw]] - AfENN + RNA –'' Archaeoglobus fulgidus''<br />
**[[1r0v]], [[1r11]] – AfENN
**[[2ohc]], [[2ohe]] - TaENN – ''Thermoplasma acidophilum''<br />
**[[2zyz]] – ENN – ''Pyrobaculum aerophilum''<br />
**[[3iey]] - ENN + NEQ261 – ''Nanoarchaeum equitans''<br />
**[[3ajv]] - ApENN  (mutant) – ''Aeropyrum pernix''<br />
**[[3p1y]] - ApENN /AfENN<br />
**[[3p1z]] - ApENN  + protein
 
*VSR ENN
 
**[[1vsr]] – EcENN<br />
**[[1cw0]] - EcENN + DNA
 
*BglI ENN
 
**[[1dmu]], [[1d2i]] – BsENN + DNA <br />
**[[1dfm]] - BsENN (mutant) + DNA
 
*BglII ENN
 
**[[1es8]] - BsENN
 
*MunI ENN
 
**[[1d02]] - ENN (mutant) + DNA - ''Mycoplasma''
 
*Sm ENN
 
**[[1smn]], [[1qae]], [[1ql0]], [[1g8t]] – ENN – ''Serratia marcescens''
 
*NaeI ENN
 
**[[1ev7]] - LaENN – ''Lechevalieria aerocolonigenes''<br />
**[[1iaw]] - LaENN + DNA
 
*NgoMIV ENN
 
**[[1fiu]], [[4abt]] - ENN + DNA – ''Neisseria gonorrheae''
 
*NEI ENN
 
**[[1tdh]] - hENN
 
*BsoBI ENN
 
**[[1dc1]] - GsENN + DNA
 
*Bse634I ENN
 
**[[1knv]] – GsENN<br />
**[[3v1z]] – GsENN + DNA<br />
**[[3v20]], [[3v21]] - GsENN (mutant) + DNA
 
*HincII ENN
 
**[[1kc6]], [[1tw8]], [[1xhu]], [[1xhv]], [[1tx3]], [[2gie]] - HiENN + DNA – ''Haemophilus influenza''<br />
**[[2gig]], [[2gih]], [[2gii]], [[2gij]], [[3e3y]], [[3e40]], [[3e41]], [[3e42]], [[3e43]], [[3e44]], [[3e45]], [[3ebc]] - HiENN (mutant) + DNA<br />
**[[2aud]] – HiENN
 
*HinDIII ENN
 
**[[2e52]], [[3a4k]] - HiENN + DNA
 
*HinP1I ENN
 
**[[1ynm]] – HiENN<br />
**[[2fkc]], [[2fkh]], [[2fl3]], [[2flc]] - HiENN + DNA
 
*Flap ENN
 
**[[1mc8]] - PhENN (mutant) <br />
**[[3ory]]– ENN – ''Desulfurococcus amylolyticus''<br />
**[[3q8k]], [[3q8l]], [[3q8m]] - hENN + DNA<br />
**[[1rxv]], [[1rxw]] - AfENN + DNA<br />
**[[1ul1]] - hENN + PCNA <br />
**[[2izo]] - SsENN + PCNA – ''Sulfolobus solfataricus''<br />
**[[1a76]], [[1a77]] - MjENN  <br />
**[[1b43]] – PfENN – ''Pyrococcus furiosus''<br />
**[[1rxz]] - AfENN + PCNA <br />
**[[4wa8]] – ENN – ''Methanopyrus kandleri''<br />
 
*DNA mismatch ENN
 
**[[1odg]] - EcENN + DNA<br />
**[[1h7u]] – hENN<br />
 
*Vvn ENN
 
**[[1ouo]] – VvENN – ''Vibrio vulnificus''<br />
**[[1oup]], [[2ivk]] - VvENN + DNA
 
*BfiI ENN
 
**[[2c1l]] – ENN – ''Bacillus firmus''
 
*SfiI ENN
 
**[[2ezv]], [[2f03]] – ENN + DNA – synthetic
 
*Ecl18kI ENN
 
**[[2fqz]], [[2gb7]] – ENN + DNA – ''Enterobacter cloacae''
 
*SdaI ENN
 
**[[2ixs]] – ENN – ''Streptomyces diastaticus''
 
*PabI ENN
 
**[[2dvy]] – ENN – ''Pyrococcus abyssi''
 
*PspGI ENN
 
**[[3bm3]] – ENN – ''Pyrococcus''
 
*NHN ENN
 
**[[2qgp]], [[4h6d]] – ENN – ''Geobacter metallireducens''
 
*UV damage ENN
 
**[[2j6v]], [[3bzg]], [[3c0s]] – TtENN <br />
**[[3bzj]], [[3c0l]], [[3c0q]] - TtENN (mutant)<br />
**[[3tc3]] - SaENN <br />
**[[4gle]] - SaENN + DNA<br />
 
*NotI ENN
 
**[[3bvq]] - NoENN – ''Nocardia otitidiscaviarum''<br />
**[[3c25]] - NoENN + DNA
 
*BpujI ENN
 
**[[2vla]], [[3s1s]] – ENN – ''Bacillus pumilus''
 
*Sau3AI ENN
 
**[[2reu]] – ENN C terminal – ''Staphylococcus aureus''
 
*HpyI ENN
 
**[[3fc3]], [[3gox]] – HpENN99 + DNA – ''Helicobacter pylori''<br />
**[[3or3]] – HpENN88 + DNA
 
*PacI ENN
 
**[[3ldy]], [[3m7k]] - PaENN + DNA – ''Psdeudomonas alcaligenes''
 
*Crossover junction ENN
 
**[[2kpf]] - ENN – mouse<br />
**[[2ziw]], [[2zix]], [[2ziu]] – hENN EME1 + Mus81<br />
**[[2ziv]] – hENN EME1 (mutant) + Mus81<br />
**[[4p0p]], [[4p0q]], [[4p0r]], [[4p0s]] – hENN EME1 + Mus81 + DNA<br />
 
*OkrAI ENN
 
**[[3odh]] - ENN + DNA – ''Oceanobacter kriegii''
 
*BspD6I ENN
 
**[[2ewf]] - ENN – ''Bacillus''
 
*ThaI ENN
 
**[[3ndh]] - TaENN + DNA
 
*Xpf ENN
 
**[[1z00]], [[2a1j]] - hENN C terminal + DNA excision repair protein<br />
**[[2aq0]] – hENN residues 823-905 – NMR<br />
**[[2kn7]] – hENN residues 823-905 + DNA – NMR<br />
**[[2bgw]] - ApENN + DNA <br />
**[[2bhn]] - ApENN <br />
 
*'''Intron-encoded endonuclease'''
 
*I-PpoI ENN
 
**[[1a74]], [[1ipp]], [[1a73]], [[1cz0]] - PpENN + DNA – ''Physarum polycephalum''<br />
**[[1cyq]], [[1evw]], [[2o6m]] - PpENN (mutant) + DNA<br />
**[[1evx]] - PpENN
 
*I-CreI ENN
 
**[[1bp7]], [[1g9y]], [[1g9z]], [[1n3e]], [[1n3f]], [[2vbj]], [[2vbl]], [[2vbn]], [[2vbo]], [[4aqu]], [[4aqx]] - CrENN + DNA <br />
**[[1u0c]], [[1u0d]], [[1t9i]], [[1t9j]], [[2i3p]], [[2i3q]], [[4aab]], [[4aad]], [[4aae]], [[4aaf]], [[4aag]] - CrENN (mutant) + DNA<br />
**[[2o7m]] - CrENN
 
*I-CeuI ENN
 
**[[2ex5]] - ENN (mutant) + DNA – ''Chlamydomonas eugametos''
 
*I-DmoI ENN
 
**[[1b24]], [[2vs7]], [[2vs8]], [[4un7]], [[4un8]], [[4un9]], [[4una]], [[4unb]], [[4unc]], [[4ut0]], [[4d6n]], [[4d6o]] - DmENN + DNA – ''Desulfurococcus mobilis''<br />
**[[1mow]] – DmENN/CrENN + DNA
 
*I-AniI ENN
 
**[[1p8k]], [[2qoj]], [[3uvf]] - EnENN + DNA – ''Emericella nidulans''<br />
**[[3eh8]] - EnENN (mutant) + DNA
 
*I-HmuI ENN
 
**[[1u3e]] - ENN + DNA – Bacillus phage spo1
 
*I-TevI ENN
 
**[[1i3j]], [[1t2t]] - T4ENN + DNA<br />
**[[1ln0]], [[1mk0]] – T4ENN (mutant)
 
*I-SceI ENN
 
**[[1dfa]], [[1ef0]] – yENN – yeast<br />
**[[1gpp]] – yENN (mutant) <br />
**[[1lws]], [[1lwt]], [[1r7m]], [[3c0w]], [[3c0x]], [[3ool]] - yENN + DNA<br />
**[[3oor]] - yENN (mutant) + DNA
 
*I-PkoII ENN
 
**[[2cw7]], [[2cw8]] – ENN – ''Thermococcus kodakarensis''
 
*I-MspI ENN
 
**[[1sa3]], [[1yfi]], [[2fld]] – ENN + DNA – ''Moraxella''
 
*I-PfuI ENN
 
**[[1dq3]] – PfENN
 
*I-Tsp061I ENN
 
**[[2dch]] – ENN – ''Thermoproteus''
 
*I-Vdi141I ENN
 
**[[3e54]] – ENN – ''Vulcanisaeta distribute''
 
*I-MtuI ENN
 
**[[3ifj]], [[3igd]] - MtENN (mutant) – ''Mycobacterium tuberculosis''<br />
**[[2l8l]] - MtENN
 
*I-MsoI ENN
 
**[[1m5x]], [[3fd2]] – MoENN + DNA – ''Monomastix''<br />
**[[3ko2]] – MoENN (mutant) + DNA


*I-GzeMII ENN
</StructureSection>


**[[4efj]] – ENN + DNA – ''Gibberella zeae''
== References ==
<references/>


*I-tRNA ENN


**[[4fz2]] – MoENN – ''Candidatus micrarchaeum''<br />
}}
[[Category:Topic Page]]
[[Category:Topic Page]]
[[Category:Endonuclease]]

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman
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