Estrogen receptor: Difference between revisions
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==Estrogen receptors== | ==Estrogen receptors== | ||
(ER) are activated by the hormone estrogen (EST). It is a [[Nuclear receptors|nuclear receptor]]. The activated ER binds DNA and regulates the activity of many genes. There are 2 forms of ER: α and β and ER dimers can be of αα, ββ and αβ. ER is composed of 5 domains: N terminal A/B domain can transactivate transcription without binding estrogen; C domain (DBD) binds to Estrogen response elements of DNA; D domain is a hinge region; E domain is ligand binding (LBD) as well as binding the coactivator and corepressor proteins and transactivates gene transcription.<br /> | (ER) are activated by the hormone estrogen (EST). It is a [[Nuclear receptors|nuclear receptor]]. The activated ER binds DNA and regulates the activity of many genes. There are 2 forms of ER: α and β and ER dimers can be of αα, ββ and αβ. The 2 forms differ in the tissues in which they are found. ER is composed of 5 domains: N terminal A/B domain can transactivate transcription without binding estrogen; C domain (DBD) binds to Estrogen response elements of DNA; D domain is a hinge region; E domain is ligand binding (LBD) as well as binding the coactivator and corepressor proteins and transactivates gene transcription.<br /> | ||
See also [[Intracellular receptors]] | |||
==Structure of estradiol metal chelate and estrogen receptor complex: The basis for designing a new class of SERMs <ref>PMID: 21473635</ref>== | ==Structure of estradiol metal chelate and estrogen receptor complex: The basis for designing a new class of SERMs <ref>PMID: 21473635</ref>== | ||
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==Estrogen receptor α complexed with raloxifene and a corepressor peptide== | ==Estrogen receptor α complexed with raloxifene and a corepressor peptide== | ||
<scene name='Estrogen_receptor/Cv/1'>Click here to see the difference between conformations</scene> of estrogen receptor α complexed with | <scene name='Estrogen_receptor/Cv/1'>Click here to see the difference between conformations</scene> of estrogen receptor α complexed with its modulator [[Raloxifene]] and a corepressor peptide (morph was taken from [http://molmovdb.org/cgi-bin/movie.cgi Gallery of Morphs] of the [http://molmovdb.org Yale Morph Server]). | ||
==3D structures of estrogen receptor== | ==3D structures of estrogen receptor== | ||
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==For more details see== | ==For more details see== | ||
[[Hormone]] | [[Hormone]]<br /> | ||
[[Ivan Koutsopatriy estrogen receptor]]<br /> | [[Ivan Koutsopatriy estrogen receptor]]<br /> | ||
[[C-di-GMP receptors with PilZ domain]]<br /> | [[C-di-GMP receptors with PilZ domain]]<br /> | ||
[[Estrogens]]<br /> | |||
For more details on ERβ see [[Student Project 10 for UMass Chemistry 423 Spring 2015]]<br /> | For more details on ERβ see [[Student Project 10 for UMass Chemistry 423 Spring 2015]]<br /> | ||
For more details on ER-Tamoxifen complex see [[Tamoxifen]]. | For more details on ER-Tamoxifen complex see [[Tamoxifen]]. | ||