4f4c: Difference between revisions

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 ==The Crystal Structure of the Multi-Drug Transporter==
-<StructureSection load='4f4c' size='340' side='right' caption='[[4f4c]], [[Resolution|resolution]] 3.40&Aring;' scene=''>
+<StructureSection load='4f4c' size='340' side='right'caption='[[4f4c]], [[Resolution|resolution]] 3.40&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[4f4c]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Caenorhabditis_elegans Caenorhabditis elegans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4F4C OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4F4C FirstGlance]. <br>
+<table><tr><td colspan='2'>[[4f4c]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Caenorhabditis_elegans Caenorhabditis elegans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4F4C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4F4C FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=0SA:UNDECYL+4-O-ALPHA-D-GLUCOPYRANOSYL-1-THIO-BETA-D-GLUCOPYRANOSIDE'>0SA</scene>, <scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=NDG:2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE'>NDG</scene></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.4&#8491;</td></tr>
-<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">pgp-1, K08E7.9 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=6239 Caenorhabditis elegans])</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0SA:UNDECYL+4-O-ALPHA-D-GLUCOPYRANOSYL-1-THIO-BETA-D-GLUCOPYRANOSIDE'>0SA</scene>, <scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Xenobiotic-transporting_ATPase Xenobiotic-transporting ATPase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.3.44 3.6.3.44] </span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4f4c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4f4c OCA], [https://pdbe.org/4f4c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4f4c RCSB], [https://www.ebi.ac.uk/pdbsum/4f4c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4f4c ProSAT]</span></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4f4c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4f4c OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4f4c RCSB], [http://www.ebi.ac.uk/pdbsum/4f4c PDBsum]</span></td></tr>
 </table>
+== Function ==
+[https://www.uniprot.org/uniprot/PGP1_CAEEL PGP1_CAEEL] Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells.
 <div style="background-color:#fffaf0;">
 == Publication Abstract from PubMed ==
@@ Line 16: / Line 18: @@
 From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 </div>
+<div class="pdbe-citations 4f4c" style="background-color:#fffaf0;"></div>
 == References ==
 <references/>
@@ Line 21: / Line 24: @@
 </StructureSection>
 [[Category: Caenorhabditis elegans]]
-[[Category: Xenobiotic-transporting ATPase]]
+[[Category: Large Structures]]
-[[Category: Chen, J]]
+[[Category: Chen J]]
-[[Category: Jin, M S]]
+[[Category: Jin MS]]
-[[Category: Oldham, M L]]
+[[Category: Oldham ML]]
-[[Category: Zhang, Q]]
+[[Category: Zhang Q]]
-[[Category: Abc transporter]]
-[[Category: Atp binding]]
-[[Category: Atpase]]
-[[Category: Exporter]]
-[[Category: Hydrolase]]
-[[Category: Multi-drug transporter]]
-[[Category: Protein transport]]