Interferon: Difference between revisions
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*'''Interferon-γ''' induces macrophage stimulation toward antimicrobial and antitumor pathways<ref>PMID:14525967</ref> | *'''Interferon-γ''' induces macrophage stimulation toward antimicrobial and antitumor pathways<ref>PMID:14525967</ref> | ||
*'''Interferon-λ''' has dual role in innate immunity and in long-term immunomodulatory effects on T- and B-cells<ref>PMID:28293236</ref> | |||
*'''Interferon-τ''' functions in ensuring pregnancy continuation in ovine and bovine conceptuses<ref>PMID:17662642</ref> | |||
*'''Interferon-ω''' has potent antiviral activity against several DNA and RNA viruses<ref>PMID:9345398</ref> | |||
==Type I== | ==Type I== | ||
Type I interferons are homologous helical cytokines that effect a wide variety of cells pleiotropically. These effects range from antiviral activity to antibacterial, antiprozoal, immunodulatory, and cell growth regulatory functions. Without Type I interferons, the survival of the higher vertebrates would be impossible. Because of their strong antiviral and antiproliferative effects, these interferons are used in the treatment of numerous cancers, hepatitis C, and multiple sclerosis. See [[Multiple sclerosis]]. | Type I interferons are homologous helical cytokines that effect a wide variety of cells pleiotropically. These effects range from antiviral activity to antibacterial, antiprozoal, immunodulatory, and cell growth regulatory functions. Without Type I interferons, the survival of the higher vertebrates would be impossible. Because of their strong antiviral and antiproliferative effects, these interferons are used in the treatment of numerous cancers, hepatitis C, and multiple sclerosis. See [[Multiple sclerosis]]. | ||