Interleukin-1 receptor-associated kinase: Difference between revisions
Michal Harel (talk | contribs) No edit summary |
Michal Harel (talk | contribs) No edit summary |
||
| (5 intermediate revisions by the same user not shown) | |||
| Line 2: | Line 2: | ||
== Function == | == Function == | ||
'''Interleukin-1 receptor-associated kinase''' (IRAK) is a kinase involved in signaling innate immune responses from Toll-like receptors and interleukin-1 receptor-related proteins<ref>PMID:8599092</ref>. | '''Interleukin-1 receptor-associated kinase''' (IRAK) is a kinase involved in signaling innate immune responses from Toll-like receptors and interleukin-1 receptor-related proteins<ref>PMID:8599092</ref>. | ||
*'''Interleukin-1 receptor-associated kinase 1''' (IRAK1) is a key link in the chain of events initiated by the binding of ligands to IL-R and Toll-like receptor <ref>PMID:30279971</ref>. | |||
*'''Interleukin-1 receptor-associated kinase 2''' (IRAK2) is involved in ER stress-induced cell death<ref>PMID:23724040</ref>. | |||
*'''Interleukin-1 receptor-associated kinase 3''' (IRAK3) is a critical modulator of inflammation in innate immunity<ref>PMID:33382782</ref>. | |||
*'''Interleukin-1 receptor-associated kinase 4''' (IRAK4) has scaffold function in myddosome formation <ref>PMID:30076215</ref>. | |||
== Relevance == | == Relevance == | ||
| Line 28: | Line 32: | ||
*IRAK4 kinase domain residues 30-336; DEATH domain residues 4-106 | *IRAK4 kinase domain residues 30-336; DEATH domain residues 4-106 | ||
**[[2nru]], [[2nry]], [[2oib]], [[2o8y]], [[4rmz]] – hIRAK4 kinase domain | **[[2nru]], [[2nry]], [[2oib]], [[2o8y]], [[4rmz]] – hIRAK4 kinase domain <br /> | ||
**[[4u97]], [[4u9a]] - hIRAK4 kinase domain (mutant)<br /> | **[[4u97]], [[4u9a]] - hIRAK4 kinase domain (mutant)<br /> | ||
**[[2oic]], [[4xs2]] - hIRAK4 kinase domain + staurosporine<br /> | **[[2oic]], [[4xs2]] - hIRAK4 kinase domain + staurosporine<br /> | ||
**[[4y73]], [[4yo6]], [[4yp8]], [[4ztl]], [[4ztm]], [[4ztn]], [[5kx7]], [[5kx8]], [[5t1s]], [[5t1t]], [[5uiq]], [[5uir]], [[5uis]], [[5uit]], [[5uiu]], [[6f3d]], [[6f3e]], [[6f3g]], [[6f3i]], [[6lxy]], [[6n8g]], [[6o8u]], [[6o94]], [[6o95]], [[6o9d]], [[6thw]], [[6thx]], [[6thz]], [[6ti8]], [[6tia]], [[6uya]], [[6vql]], [[7c2v]], [[7c2w]] - hIRAK4 kinase domain + inhibitor<br /> | **[[4y73]], [[4yo6]], [[4yp8]], [[4ztl]], [[4ztm]], [[4ztn]], [[5kx7]], [[5kx8]], [[5t1s]], [[5t1t]], [[5uiq]], [[5uir]], [[5uis]], [[5uit]], [[5uiu]], [[6f3d]], [[6f3e]], [[6f3g]], [[6f3i]], [[6lxy]], [[6n8g]], [[6o8u]], [[6o94]], [[6o95]], [[6o9d]], [[6thw]], [[6thx]], [[6thz]], [[6ti8]], [[6tia]], [[6uya]], [[6vql]], [[7c2v]], [[7c2w]], [[7og1]], [[7qg2]], [[7qg3]], [[7qg5]], [[8dks]] - hIRAK4 kinase domain + inhibitor<br />, | ||
**[[5w84]], [[5w85]], [[5k72]], [[5k75]], [[5k76]], [[5k7g]], [[5k7i]], [[6ega]], [[6eg9]], [[6egd]], [[6ege]], [[6egf]], [[6mom]], [[6rfi]], [[6rfj]] - hIRAK4 residues 154-460 + inhibitor<br /> | **[[5w84]], [[5w85]], [[5k72]], [[5k75]], [[5k76]], [[5k7g]], [[5k7i]], [[6ega]], [[6eg9]], [[6egd]], [[6ege]], [[6egf]], [[6mom]], [[6rfi]], [[6rfj]] - hIRAK4 residues 154-460 + inhibitor<br /> | ||
**[[2oid]] - hIRAK4 kinase domain + AMPPNP<br /> | **[[2oid]] - hIRAK4 kinase domain + AMPPNP<br /> | ||