Interleukin-1 receptor-associated kinase: Difference between revisions

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Michal Harel, Alexander Berchansky, Jaime Prilusky

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-{{STRUCTURE_2a9i|  PDB=2a9i  | SIZE=400| SCENE= |right|CAPTION=Mouse IRAK4 death domain complex with Mn+2 ion , [[2a9i]] }}
+<StructureSection load='2a9i' size='340' side='right' caption='Mouse IRAK4 death domain complex with Mn+2 ion , [[2a9i]]' scene=''>
+== Function ==
+'''Interleukin-1 receptor-associated kinase''' (IRAK) is a kinase involved in signaling innate immune responses from Toll-like receptors and interleukin-1 receptor-related proteins<ref>PMID:8599092</ref>.
+*'''Interleukin-1 receptor-associated kinase 1''' (IRAK1) is a key link in the chain of events initiated by the binding of ligands to IL-R and Toll-like receptor <ref>PMID:30279971</ref>.
+*'''Interleukin-1 receptor-associated kinase 2''' (IRAK2) is involved in ER stress-induced cell death<ref>PMID:23724040</ref>.
+*'''Interleukin-1 receptor-associated kinase 3''' (IRAK3) is a critical modulator of inflammation in innate immunity<ref>PMID:33382782</ref>.
+*'''Interleukin-1 receptor-associated kinase 4''' (IRAK4) has scaffold function in myddosome formation <ref>PMID:30076215</ref>.
-<!--
+== Relevance ==
-Please use the "3D" button above this box to insert a Jmol applet (molecule) on this page.
+IRAK4 is involved in early recognition of pathogens and the initiation of inflammation when fighting infection.
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-to a Jmol applet. Check out the other buttons as well!
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-'''Interleukin-1 receptor-associated kinase 4''' (IRAK4) is a kinase involved in signaling innate immune responses from Toll-like receptors and interleukin-1 receptor-related proteins.  IRAK4 is involved in early recognition of pathogens and the initiation of inflammation when fighting infection.  IRAK4 deficiency is a disorder which causes recurrent bacterial infections.
-==3D structures of IRAK4==
+== Disease ==
+IRAK4 deficiency is a disorder which causes recurrent bacterial infections.
+</StructureSection>
+==3D structures of interleukin-1 receptor-associated kinase==
+Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
+{{#tree:id=OrganizedByTopic|openlevels=0|
+*IRAK1
+**[[6bfn]] – hIRAK1 residues 194-530 - human<br />
-[[2nru]], [[2nry]], [[2oib]], [[2o8y]] – hIRAK4 kinase domain - human<br />
+*IRAK2
-[[1wh4]] – mIRAK4 DEATH domain – mouse – NMR<br />
-[[2a9i]] - mIRAK4 DEATH domain<br />
+**[[3mop]] – hIRAK2 DEATH domain + hIRAK4 DEATH domain + MYD88 <br />
-[[2oic]] - hIRAK4 kinase domain + staurosporine<br />
-[[2oid]] - hIRAK4 kinase domain + AMPPNP<br />
+*IRAK3; Domains – DEATH 4-106; pseudokinase 145-454
-[[3mop]] - hIRAK4 DEATH domain + hIRAK2 DEATH domain + MYD88
+**[[5uke]] – hIRAK3 DEATH domain (mutant) - NMR<br />
+**[[6ziw]] – hIRAK3 pseudokinase domain + ATPgS <br />
+**[[6ruu]] – hIRAK3 pseudokinase domain <br />
+*IRAK4 kinase domain residues 30-336; DEATH domain residues 4-106
+**[[2nru]], [[2nry]], [[2oib]], [[2o8y]], [[4rmz]] – hIRAK4 kinase domain <br />
+**[[4u97]], [[4u9a]] - hIRAK4 kinase domain (mutant)<br />
+**[[2oic]], [[4xs2]] - hIRAK4 kinase domain + staurosporine<br />
+**[[4y73]], [[4yo6]], [[4yp8]], [[4ztl]], [[4ztm]], [[4ztn]], [[5kx7]], [[5kx8]], [[5t1s]], [[5t1t]], [[5uiq]], [[5uir]], [[5uis]], [[5uit]], [[5uiu]], [[6f3d]], [[6f3e]], [[6f3g]], [[6f3i]], [[6lxy]], [[6n8g]], [[6o8u]], [[6o94]], [[6o95]], [[6o9d]], [[6thw]], [[6thx]], [[6thz]], [[6ti8]], [[6tia]], [[6uya]], [[6vql]], [[7c2v]], [[7c2w]], [[7og1]], [[7qg2]], [[7qg3]], [[7qg5]], [[8dks]] - hIRAK4 kinase domain + inhibitor<br />,
+**[[5w84]], [[5w85]], [[5k72]], [[5k75]], [[5k76]], [[5k7g]], [[5k7i]], [[6ega]], [[6eg9]], [[6egd]], [[6ege]], [[6egf]], [[6mom]], [[6rfi]], [[6rfj]] - hIRAK4 residues 154-460 + inhibitor<br />
+**[[2oid]] - hIRAK4 kinase domain + AMPPNP<br />
+**[[3mop]] - hIRAK4 DEATH domain + hIRAK2 DEATH domain + MYD88<br />
+**[[1wh4]] – mIRAK4 DEATH domain – mouse – NMR<br />
+**[[2a9i]] - mIRAK4 DEATH domain<br />
+}}
+== References ==
+<references/>
 [[Category:Topic Page]]