Chemotaxis protein: Difference between revisions

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{{STRUCTURE_1e6m| PDB=1e6m | SIZE=400| SCENE= |right|CAPTION=E. coli CheY [[1e6m]] }}
<StructureSection load='1e6m' size='350' side='right' caption='E. coli CheY (PDB entry [[1e6m]])' scene=''>
 
'''Chemotaxis proteins''' direct cell movement according to certain chemicals in their environment.<ref>PMID:4598187</ref>
*'''CheY''' is a response regulator determining the swimming behaviour of the cell<ref>PMID:7623663</ref>.
*'''CheR''' is a SAM-dependent methyltransferase which binds to the C-terminus of some chemotaxis receptors and methylates neighbouring receptor molecules<ref>PMID:9628482</ref>.  See [[Molecular Playground/CheR]] and [[Chemotaxis receptor methyltransferase]].
*'''CheA''' is a histidine kinase which donates phosphoric groups to CheB and CheY to control swimming behaviour<ref>PMID:15090507</ref>.  See [[Molecular Playground/CheA]].
*'''CheB''' is a methyltransferase catalysing the demethylationof chemotaxis membrane receptors in ''Salmonella typhimurium''<ref>PMID:2991277</ref>.
*'''CheW''' participates in the control of CheA activity<ref>PMID:1992467</ref>. See [[Molecular Playground/Bacterial Chemotaxis Receptors]]
*'''PomA''' and '''PomB''' convert Na+ flux through channel to rotation of the flagellum in several bacteria <ref>PMID:21642461</ref>.
*'''Aspartate chemotaxis receptor''' or '''Tar''' modulates the activity of CheA<ref>PMID:8832891</ref>. See [[DNA Origami Assembly for the Tar Chemoreceptor]].
*'''Methyl-accepting chemotaxis protein''' are the predominant chemoreceptors in bacteria and archaea.  They are involved in regulation of diverse aspects of cellular activities<ref>PMID:28409190</ref>.  See [[Molecular Playground/cytoplasmic domain of a serine chemotaxis receptor]].
*'''FLiN''', '''MotA''' and '''MotB''' are involved in energizing flagellar rotation in ''E. coli''<ref>PMID:7892209</ref>.
*'''CKI1''' is a histidine kinase involved in cytokinin signal transduction<ref>PMID:8875940</ref>. See [[Receiver domain of sensor histidine kinase CKI1]].
 
See also:


'''Chemotaxis proteins''' direct cell movement according to certain chemicals in their environment.
For details on '''chemotaxis protein''' see<br />
*[[Molecular Playground/Bacterial Chemotaxis Receptors]]<br />
*[[Molecular Playground/Bacterial Chemotaxis Complex]]<br />
*[[Molecular Playground/CheA]]<br />
*[[Molecular Playground/Cytoplasmic domain of chemoreceptor of Thermotoga maritima]]<br />
*[[Molecular Playground/Cytoplasmic domain of chemoreceptor of Thermotoga maritima]]<br />
*[[Receiver domain of sensor histidine kinase CKI1]].


==3D structures of chemotaxis protein ==
==3D structures of chemotaxis protein ==
[[Chemotaxis protein 3D structures]]


Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
</StructureSection>
{{#tree:id=OrganizedByTopic|openlevels=0|
 
*CheY
 
**[[1ab6]], [[1d4z]], [[1e6m]], [[1e6k]], [[1e6l]], [[1jbe]], [[1mih]], [[3oo0]], [[3oo1]] – EcCheY (mutant) – ''Escherichia coli''<BR />
**[[1tmy]], [[2tmy]], [[3tmy]], [[4tmy]] - TmCheY – ''Thermotoga maritima''<br />
**[[4h60]], [[4hnr]] – VcCheY – ''Vibrio cholerae''<br />
**[[4hnq]] - VcCheY (mutant) <br />
**[[3gwg]] – HpCheY -  ''Helicobacter pylori''<BR />
**[[3h1f]], [[3h1g]] - HpCheY (mutant) <BR />
**[[2id7]], [[2id9]], [[2idm]] – EcCheY-phosphono (mutant) <BR />
**[[1djm]] – EcCheY – NMR<BR />
**[[2chy]] – StCheY - ''Salmonella typhimurium'' <br />
 
*''CheY complexes''
 
**[[1zdm]] – EcCheY + Xe<BR />
**[[3h1e]] - HpCheY  + BeF3 + Mn<BR />
**[[3f7n]], [[3fft]], [[3ffw]], [[3ffx]], [[3fgz]], [[3myy]], [[3olv]], [[3olw]], [[3olx]], [[3oly]] - EcCheY (mutant) + BeF3 + Mn<BR />
**[[4hns]] - VcCheY + BeF3 + Mg<br />
**[[4lx8]] - VcCheY + Mg<br />
**[[1fqw]] - EcCheY  + BeF3 + Mn<br />
**[[3rvj]], [[3rvk]], [[3rvl]], [[3rvm]], [[3rvn]], [[3rvo]], [[3rvp]], [[3rvq]], [[3rvr]], [[3rvs]] - EcCheY (mutant) + BeF3 + Mn<br />
**[[1bdj]] – EcCheY + aerobic respiration control protein HPT domain<BR />
**[[1u8t]] – EcCheY + flagellar motor switch protein FLIM<BR />
**[[2b1j]], [[1f4v]] - EcCheY + flagellar motor switch protein FLIM N terminal<br />
**[[1ffg]], [[1ffs]] – EcCheY + CheA CheY-binding domain<BR />
**[[1u0s]] - TmCheY response regulating domain + CheA P2 domain <BR />
**[[1ffw]] – EcCheY + CheA CheY-binding domain + imido phosphate<BR />
**[[1kmi]] - EcCheY + CheZ<BR />
**[[2lp4]] - EcCheY + CheA<br />
**[[2fka]], [[2flk]], [[2flw]], [[2fmf]], [[2fmh]], [[2fmi]], [[2fmk]], [[2pl9]], [[2pmc]] – StCheY + CheZ  peptide <BR />
**[[2che]], [[2chf]] – StCheY + Mg<br />
**[[4iga]] - TmCheY + flagellar motor switch protein FLIM peptide<br />
 
*CheX
 
**[[1xko]]– TmCheX<BR />
**[[3hm4]] – CheX – ''Desulfovibrio desulfuricans''<BR />
**[[3hzh]] – CheX + Che-3 – ''Borrelia burgdorferi''<br />
 
*CheC
 
**[[1xkr]] – TmCheC<BR />
**[[2f9z]] – TmCheC + CheD<BR />
**[[3qta]] – CheC – ''Haloarcula marismortui''<BR />
 
*CheR
 
**[[1bc5]] – StCheR + chemotaxis receptor peptide <BR />
**[[1af7]] – StCheR<br />
 
*CheA
 
**[[1fwp]] – EcCheA – NMR<br />
**[[1b3q]] – TmCheA dimerization, kinase and regulatory domains <BR />
**[[1i5n]] – StCheA P1 domain<br />
**[[1i58]], [[1i59]], [[1i5a]], [[1i5b]], [[1i5d]] - TmCheA P4 domain + ATP analog<br />
**[[1i5c]] - TmCheA P4 domain (mutant) + ADP<br />
**[[1tqg]] – TmCheA phosphotransferase domain<br />
**[[2ld6]] – TmCheA HPT domain - NMR<BR />
**[[2ch4]] - TmCheA kinase and regulatory domains + CheW<br />
**[[3ur1]], [[4jpb]] – TmCheA + CheW + methyl-accepting Che<br />
 
*CheB
 
**[[1a2o]], [[1chd]]– StCheB<br />
 
*CheW
 
**[[1k0s]] – TmCheW<br />
**[[2ho9]] – EcCheW - NMR<BR />
 
*Aspartate chemotaxis receptor
 
**[[1jmw]], [[1vls]] – StChe LBD<br />
**[[1lih]] – StChe LBD (mutant)<br />
**[[1was]] – StChe LBD<br />
**[[1wat]], [[1vlt]], [[2lig]] – StChe LBD + aspartate<br />
**[[2asr]] – EcChe <br />
 
*Methyl-accepting chemotaxis protein
 
**[[2m7u]], [[2m7v]] – TeMche – ''Thermosynechococcus elongatus''<br />
**[[3vv4]] – TeMche GAF domain<br />
**[[4fof]], [[4glq]] – TeMche GAF domain (mutant)<br />
**[[3w2z]] – Mche residues 221-397 – Nostoc<br />
**[[3g67]] – TmMche<BR />
**[[3g6b]] – TmMche (mutant) <BR />
**[[2ch7]] – TmMche cytoplasmic domain<BR />
**[[1qu7]] – EcMcheI cytoplasmic domain<BR />
**[[2ld6]] – EcMche peptide - NMR<BR />
**[[3atp]] -  EcMcheI LBD + serine<BR />
**[[2d4u]] – EcMcheI LBD (mutant)<br />
**[[3zx6]] – EcMcheI/HAMP<br />
**[[1jmw]] - StMche LBD (mutant) <BR />
**[[2qhk]], [[4exo]] – Mche N-terminal – ''Vibrio parahaemolyticus''<BR />
**[[3c8c]] – Mche N-terminal <BR />
**[[3b47]] – Mche periplasmic domain – ''Geobacter sulfurreducens''<BR />
**[[4it2]] - Mche H-Nox domain Mn-porphyrin – ''Caldanaerobacter subterraneus''<br />
 
*''Heme-containing methyl-accepting chemotaxis protein''
 
**[[3eee]], [[3iqb]], [[3lah]], [[3lai]], [[3sj5]], [[4fdk]] – TtMche H-Nox domain (mutant)<br />
**[[1xbn]] – TtMche – Thermoanaerobacter tengcongensis<br />
**[[1u4h]], [[1u55]], [[1u56]], [[3tf0]], [[3tf1]] - TtMche H-Nox domain<br />
**[[3m0b]] - TtMche H-Nox domain Ru-porphyrin<br />
**[[3nvr]], [[3nvu]] – TtMche N terminal (mutant)<br />
 
*Flagellar motor protein FLIN
 
**[[1yab]] – TmFLIN<BR />
 
*Chemotaxis protein MotB


**[[3cyp]], [[3imp]], [[3s02]], [[3s03]], [[3s06]], [[3s0h]], [[3s0w]], [[3s0y]] – HpMotB C terminal<br />
== References ==
**[[3cyq]] – HpMotB C terminal + N-acetylmuramic acid<BR />
<references/>
**[[2zov]], [[2zvy]], [[2zvz]] - StMotB C terminal<br />
}}
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[[Category:Topic Page]]

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Lynmarie K Thompson, Joel L. Sussman