Chemotaxis protein: Difference between revisions

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<StructureSection load='1e6m' size='350' side='right' caption='E. coli CheY (PDB entry [[1e6m]])' scene=''>


 
'''Chemotaxis proteins''' direct cell movement according to certain chemicals in their environment.<ref>PMID:4598187</ref>
For details on '''chemotaxis protein''' see [[Molecular Playground/Bacterial Chemotaxis Receptors]] and [[Molecular Playground/Cytoplasmic domain of chemoreceptor of Thermotoga maritima]].
*'''CheY''' is a response regulator determining the swimming behaviour of the cell<ref>PMID:7623663</ref>.
*'''CheR''' is a SAM-dependent methyltransferase which binds to the C-terminus of some chemotaxis receptors and methylates neighbouring receptor molecules<ref>PMID:9628482</ref>.  See [[Molecular Playground/CheR]] and [[Chemotaxis receptor methyltransferase]].
*'''CheA''' is a histidine kinase which donates phosphoric groups to CheB and CheY to control swimming behaviour<ref>PMID:15090507</ref>.  See [[Molecular Playground/CheA]].
*'''CheB''' is a methyltransferase catalysing the demethylationof chemotaxis membrane receptors in ''Salmonella typhimurium''<ref>PMID:2991277</ref>.
*'''CheW''' participates in the control of CheA activity<ref>PMID:1992467</ref>. See [[Molecular Playground/Bacterial Chemotaxis Receptors]]  
*'''PomA''' and '''PomB''' convert Na+ flux through channel to rotation of the flagellum in several bacteria <ref>PMID:21642461</ref>.
*'''Aspartate chemotaxis receptor''' or '''Tar''' modulates the activity of CheA<ref>PMID:8832891</ref>. See [[DNA Origami Assembly for the Tar Chemoreceptor]].
*'''Methyl-accepting chemotaxis protein''' are the predominant chemoreceptors in bacteria and archaea.  They are involved in regulation of diverse aspects of cellular activities<ref>PMID:28409190</ref>.  See [[Molecular Playground/cytoplasmic domain of a serine chemotaxis receptor]].
*'''FLiN''', '''MotA''' and '''MotB''' are involved in energizing flagellar rotation in ''E. coli''<ref>PMID:7892209</ref>.
*'''CKI1''' is a histidine kinase involved in cytokinin signal transduction<ref>PMID:8875940</ref>. See [[Receiver domain of sensor histidine kinase CKI1]].
 
See also:
 
*[[Molecular Playground/Cytoplasmic domain of chemoreceptor of Thermotoga maritima]]<br />


==3D structures of chemotaxis protein ==
==3D structures of chemotaxis protein ==
[[Chemotaxis protein 3D structures]]
</StructureSection>


===CheY===
== References ==
[[1ab6]], [[1d4z]], [[1e6m]], [[1e6k]], [[1e6l]], [[1jbe]], [[1mih]], [[3oo0]], [[3oo1]] – EcCheY (mutant) – ''Escherichia coli''<BR />
<references/>
[[3f7n]], [[3fft]], [[3ffw]], [[3ffx]], [[3fgz]], [[3myy]], [[3olv]], [[3olw]], [[3olx]], [[3oly]] - EcCheY (mutant) + BeF3 + Mn<BR />
[[Category:Topic Page]]
[[2id7]], [[2id9]], [[2idm]] – EcCheY-phosphono (mutant) <BR />
[[1djm]] – EcCheY – NMR<BR />
[[1zdm]] – EcCheY + Xe<BR />
[[3gwg]] – HpCheY -  ''Helicobacter pylori''<BR />
[[3h1f]], [[3h1g]] - HpCheY (mutant) <BR />
[[3h1e]] - HpCheY  + BeF3 + Mn<BR />
[[1bdj]] – EcCheY + aerobic respiration control protein HPT domain<BR />
[[1u8t]] – EcCheY + flagellar motor switch protein FLIM<BR />
[[2b1j]] - EcCheY + flagellar motor switch protein FLIM N terminal<br />
[[1ffg]], [[1ffs]] – EcCheY + CheA CheY-binding domain<BR />
[[1u0s]] - TmCheY response regulating domain + CheA P2 domain –''Thermotoga maritima''<BR />
[[1ffw]] – EcCheY + CheA CheY-binding domain + imido phosphate<BR />
[[1kmi]] - EcCheY + CheZ<BR />
[[2fka]], [[2flk]], [[2flw]], [[2fmf]], [[2fmh]], [[2fmi]], [[2fmk]], [[2pl9]], [[2pmc]] – StCheY + CheZ  peptide - ''Salmonella typhimurium''<BR />
===CheX===
[[1xko]]– TmCheX<BR />
[[3hm4]] – CheX – ''Desulfovibrio desulfuricans''<BR />
===CheC===
[[1xkr]] – TmCheC<BR />
[[2f9z]] – TmCheC + CheD<BR />
[[3qta]] – CheC – ''Haloarcula marismortui''<BR />
===CheR===
[[1bc5]] – StCheR + chemotaxis receptor peptide <BR />
===CheA===
[[1b3q]] – TmCheA dimerization, kinase and regulatory domains <BR />
[[1i5n]] – StCheA P1 domain<br />
[[1i58]], [[1i59]], [[1i5a]], [[1i5b]], [[1i5d]] - TmCheA P4 domain + ATP analog<br />
[[1i5c]] - TmCheA P4 domain (mutant) + ADP<br />
[[1tqg]] – TmCheA phosphotransferase domain<br />
[[2ld6]] – TmCheA HPT domain - NMR<BR />
[[2ch4]] - TmCheA kinase and regulatory domains + CheW
===CheW===
[[1k0s]] – TmCheW<br />
[[2h09]] – EcCheW - NMR<BR />
===Methyl-accepting chemotaxis protein===
[[1xbn]] – TtMche – ''Thermoanaerobacter tengcongensis''<BR />
[[3eee]], [[3iqb]], [[3lah]], [[3lai]], [[3sj5]] – TtMche H-Nox domain (mutant) <BR />
[[3tf0]], [[3tf1]] - TtMche H-Nox domain<BR />
[[3m0b]] - TtMche H-Nox domain Ru-porphyrin<BR />
[[3nvr]], [[3nvu]] – TtMche N terminal (mutant) <BR />
[[3g67]] – TmMche<BR />
[[3g6b]] – TmMche (mutant) <BR />
[[2ch7]] – TmMche cytoplasmic domain<BR />
[[1qu7]], [[2l9g]] – EcCheI cytoplasmic domain<BR />
[[2ld6]] – EcChe peptide - NMR<BR />
[[3atp]] -  EcCheI ligand-binding domain + serine<BR />
[[1jmw]] - StChe ligand-binding domain (mutant) <BR />
[[2qhk]] – Che residues 31-203 – ''Vibrio parahaemolyticus''<BR />
[[3c8c]] – Che N-terminal – ''Vibrio cholerae''<BR />
[[3b47]] – Che periplasmic domain – ''Geobacter sulfurreducens''<BR />
===Flagellar motor protein FLIN===
[[1yab]] – TmFLIN<BR />
===Chemotaxis protein MotB===
[[3cyp]], [[3imp]] – HpMotB C terminal<br />
[[3cyq]] – HpMotB C terminal + N-acetylmuramic acid<BR />
[[2zov]], [[2zvy]], [[2zvz]] - StMotB C terminal<br />

Latest revision as of 11:28, 27 January 2025


Chemotaxis proteins direct cell movement according to certain chemicals in their environment.[1]

See also:

3D structures of chemotaxis protein

Chemotaxis protein 3D structures


E. coli CheY (PDB entry 1e6m)

Drag the structure with the mouse to rotate

ReferencesReferences

  1. ↑ Adler J, Tso WW. "Decision"-making in bacteria: chemotactic response of Escherichia coli to conflicting stimuli. Science. 1974 Jun 21;184(4143):1292-4. PMID:4598187
  2. ↑ Sanna MG, Swanson RV, Bourret RB, Simon MI. Mutations in the chemotactic response regulator, CheY, that confer resistance to the phosphatase activity of CheZ. Mol Microbiol. 1995 Mar;15(6):1069-79. PMID:7623663 doi:10.1111/j.1365-2958.1995.tb02282.x
  3. ↑ Djordjevic S, Stock AM. Chemotaxis receptor recognition by protein methyltransferase CheR. Nat Struct Biol. 1998 Jun;5(6):446-50. PMID:9628482
  4. ↑ Jahreis K, Morrison TB, Garzón A, Parkinson JS. Chemotactic signaling by an Escherichia coli CheA mutant that lacks the binding domain for phosphoacceptor partners. J Bacteriol. 2004 May;186(9):2664-72. PMID:15090507 doi:10.1128/JB.186.9.2664-2672.2004
  5. ↑ Simms SA, Keane MG, Stock J. Multiple forms of the CheB methylesterase in bacterial chemosensing. J Biol Chem. 1985 Aug 25;260(18):10161-8. PMID:2991277
  6. ↑ Gegner JA, Dahlquist FW. Signal transduction in bacteria: CheW forms a reversible complex with the protein kinase CheA. Proc Natl Acad Sci U S A. 1991 Feb 1;88(3):750-4. PMID:1992467 doi:10.1073/pnas.88.3.750
  7. ↑ Yonekura K, Maki-Yonekura S, Homma M. Structure of the flagellar motor protein complex PomAB: implications for the torque-generating conformation. J Bacteriol. 2011 Aug;193(15):3863-70. PMID:21642461 doi:10.1128/JB.05021-11
  8. ↑ Tatsuno I, Homma M, Oosawa K, Kawagishi I. Signaling by the Escherichia coli aspartate chemoreceptor Tar with a single cytoplasmic domain per dimer. Science. 1996 Oct 18;274(5286):423-5. PMID:8832891 doi:10.1126/science.274.5286.423
  9. ↑ Salah Ud-Din AIM, Roujeinikova A. Methyl-accepting chemotaxis proteins: a core sensing element in prokaryotes and archaea. Cell Mol Life Sci. 2017 Sep;74(18):3293-3303. PMID:28409190 doi:10.1007/s00018-017-2514-0
  10. ↑ Garza AG, Harris-Haller LW, Stoebner RA, Manson MD. Motility protein interactions in the bacterial flagellar motor. Proc Natl Acad Sci U S A. 1995 Mar 14;92(6):1970-4. PMID:7892209 doi:10.1073/pnas.92.6.1970
  11. ↑ Kakimoto T. CKI1, a histidine kinase homolog implicated in cytokinin signal transduction. Science. 1996 Nov 8;274(5289):982-5. PMID:8875940

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