3v89: Difference between revisions

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-[[Image:3v89.jpg|left|200px]]
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+==The crystal structure of transferrin binding protein A (TbpA) from Neisseria meningitidis serogroup B in complex with the C-lobe of human transferrin==
-The line below this paragraph, containing "STRUCTURE_3v89", creates the "Structure Box" on the page.
+<StructureSection load='3v89' size='340' side='right'caption='[[3v89]], [[Resolution|resolution]] 3.10&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[3v89]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Neisseria_meningitidis_serogroup_B Neisseria meningitidis serogroup B]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3V89 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3V89 FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.1&#8491;</td></tr>
--->
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3v89 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3v89 OCA], [https://pdbe.org/3v89 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3v89 RCSB], [https://www.ebi.ac.uk/pdbsum/3v89 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3v89 ProSAT]</span></td></tr>
-{{STRUCTURE_3v89|  PDB=3v89  |  SCENE=  }}
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/TBPA_NEIMB TBPA_NEIMB] Neisseria acquires iron by extracting it from serum transferrin (TF) in its human host. Acts as a TF receptor and is required for TF utilization. Binds both apo- and holo-TF, via the TF C-terminus.<ref>PMID:22327295</ref>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+Neisseria are obligate human pathogens causing bacterial meningitis, septicaemia and gonorrhoea. Neisseria require iron for survival and can extract it directly from human transferrin for transport across the outer membrane. The transport system consists of TbpA, an integral outer membrane protein, and TbpB, a co-receptor attached to the cell surface; both proteins are potentially important vaccine and therapeutic targets. Two key questions driving Neisseria research are how human transferrin is specifically targeted, and how the bacteria liberate iron from transferrin at neutral pH. To address these questions, we solved crystal structures of the TbpA-transferrin complex and of the corresponding co-receptor TbpB. We characterized the TbpB-transferrin complex by small-angle X-ray scattering and the TbpA-TbpB-transferrin complex by electron microscopy. Our studies provide a rational basis for the specificity of TbpA for human transferrin, show how TbpA promotes iron release from transferrin, and elucidate how TbpB facilitates this process.
-===The crystal structure of transferrin binding protein A (TbpA) from Neisseria meningitidis serogroup B in complex with the C-lobe of human transferrin===
+Structural basis for iron piracy by pathogenic Neisseria.,Noinaj N, Easley NC, Oke M, Mizuno N, Gumbart J, Boura E, Steere AN, Zak O, Aisen P, Tajkhorshid E, Evans RW, Gorringe AR, Mason AB, Steven AC, Buchanan SK Nature. 2012 Feb 12. doi: 10.1038/nature10823. PMID:22327295<ref>PMID:22327295</ref>
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+</div>
+<div class="pdbe-citations 3v89" style="background-color:#fffaf0;"></div>
-==About this Structure==
+==See Also==
-[[3v89]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Neisseria_meningitidis_serogroup_b Neisseria meningitidis serogroup b]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3V89 OCA].
+*[[Transferrin-binding protein|Transferrin-binding protein]]
+== References ==
+<references/>
+__TOC__
+</StructureSection>
 [[Category: Homo sapiens]]
-[[Category: Neisseria meningitidis serogroup b]]
+[[Category: Large Structures]]
-[[Category: Aisen, P.]]
+[[Category: Neisseria meningitidis serogroup B]]
-[[Category: Buchanan, S K.]]
+[[Category: Aisen P]]
-[[Category: Easley, N.]]
+[[Category: Buchanan SK]]
-[[Category: Noinaj, N.]]
+[[Category: Easley N]]
-[[Category: Oke, M.]]
+[[Category: Noinaj N]]
-[[Category: Zak, O.]]
+[[Category: Oke M]]
-[[Category: Iron binding]]
+[[Category: Zak O]]
-[[Category: Membrane protein-metal transport complex]]
-[[Category: Tonb-dependent transporter]]